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PHL425 assignment Write mechanism of action of the following anticancer drugs: a) Paclitaxel (Marks= 1) It interferes with cell mitotic spindle, preventing microtubule disassembly into tubulin monomers…………………….………………………...……………………………………………………………………………………… ………………………………………………………………………………………………………………………………………………………… ………………………………………………………………………………………………………………………………………………………… b) Tamoxifen (Marks = 1) Blocks the binding of estrogen to receptors of estrogen sensitive cancer cells ………………………….……………………..……………………………………………………………………………………………………… ………………………………………………………………………………………………………………………………………………………… ………………………………………………………………………………………………………………………………………………………… c) Imatinib (Marks= 1) Acts by inhibiting tyrosine kinase activity of the protein product of the Bcr-Abl oncogene ………………………………………………………………………………………………………………………………………………………… ………………………………………………………………………………………………………………………………………………………… d) Bleomycin (Marks =1) Acts through binding to DNA, which results in single and double strand breaks following free radical formation and inhibition of DNA synthesis ………………………………………………………………………………………………………………………..................................... ..............................................................................................................................................................
