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Transcript
PHL425 assignment
Write mechanism of action of the following anticancer drugs:
a) Paclitaxel
(Marks= 1)
It interferes with cell mitotic spindle, preventing microtubule disassembly into tubulin
monomers…………………….………………………...………………………………………………………………………………………
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b) Tamoxifen
(Marks = 1)
Blocks the binding of estrogen to receptors of estrogen sensitive cancer cells
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c) Imatinib
(Marks= 1)
Acts by inhibiting tyrosine kinase activity of the protein product of the Bcr-Abl oncogene
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d) Bleomycin
(Marks =1)
Acts through binding to DNA, which results in single and double strand breaks following
free radical formation and inhibition of DNA synthesis
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