Download PostDoc position at the Division of Cell Biology @ Biocenter

PostDoc position at the Division of Cell Biology @ Biocenter, Innsbruck
A PostDoc Position is available in the Group ‘Membrane Traffic and Signaling’
(Group: David Teis) at the BIOCENTER @ Innsbruck Medical University, Innsbruck,
Austria (http://www.i-med.ac.at/biocenter/) in the Division of Cell Biology
(http://www.i-med.ac.at/cellbio/).
We are looking for a motivated PostDoc with a strong background in cell- and
molecular biology and/or biochemistry.
The aim of the project is to identify molecular mechanisms that mediate and control
lysosomal protein degradation. Defects in lysosomal protein degradation have fatal
consequences and are associated with a wide variety of diseases including cancer
and neuro-degeneration.
We focus on two main questions:
1. What is the molecular mechanism underlying the ESCRT pathway, which is
required for the transport of ubiquitinated membrane proteins (e.g. EGFR) into
lysosomes?
2. What are the physiological consequences when membrane proteins are no
longer delivered into lysosomes for degradation (e.g. upon loss of ESCRT
function)? Do cells respond to the accumulation of membrane proteins by
activating a specific stress response?
To address these questions, we are using yeast and epithelial cells as the best suited
model systems.
The position is open immediately.
Applicants should have a strong background in molecular biology and biochemistry.
If interested, please send your application (CV & two contacts for reference) per
email to David Teis ([email protected]) before the end of Dec. 2012.
References:
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Schmidt, O., and Teis, D. (2012). The ESCRT machinery. Current Biology, 22, 116-120.
Adell, M.A., and Teis, D. (2011). Assembly and disassembly of the ESCRT-III
membrane scission complex. FEBS Lett 585, 3191-3196.
Teis, D.,* Saksena, S., Judson, B.L., and Emr, S.D.* (2010). ESCRT-II coordinates the
assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle
formation. EMBO J 29, 871-883. *corresponding author
Teis, D., Saksena, S., and Emr, S.D.* (2008). Ordered assembly of the ESCRT-III
complex on endosomes is required to sequester cargo during MVB formation. Dev Cell
15, 578-589.