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SoonChunHyang University: SoonChunHyang Institute of Medi-Bio Science (SIMS) 4661 – Advanced Molecular Biology I (3 units) Spring 2016 Course Director : Youngjo Kim and Jaeseok Han Email: [email protected], [email protected] Course Description : The course objective is to consider both principles and current topics in Molecular Biology in depth. This course primarily deals with nucleic acids and proteins and how these molecules interact within the cell to promote proper growth, division, and development. Especially this course will emphasize the molecular mechanisms of DNA replication, repair, transcription, protein synthesis, and gene regulation in different organisms. Students are expected to learn the basic concepts and experimental techniques used to discern these mechanisms, referring to text book and the original scientific articles, respectively. Reading assigned textbook is strongly recommended for this course. Course requirement : Each class consists of the lecture by the instructor and in class discussion. Therefore, class attendance is required to participate in the discussion. Students will prepare a presentation to be given during class. Original research articles relevant to the topics of each class will be posted ahead of the class. Grading Procedure : The final grade is based on class attendance (10%), class participation (20%), midterm exam (30%), and the final exam (40%). Class Schedule Weeks Topic 1 Introduction to course, A brief history 2 Nucleic acids, proteins and analysis tools 3 Methods in Molecular Biology 4 DNA replication, DNA damage and repair 5 DNA replication II: Detailed Mechanism Weeks Topic 6 Homologous recombination 7 Introduction to Genomics 8 Midterm exam 9 Eukaryotic transcription I 10 Eukaryotic transcription II 11 Chromatin structure & its effects on transcription 12 RNA processing 13 Post-transcriptional control of gene expression 14 Translation I 15 Translation II 16 Final exam