Download The Innate Immune Response in the Pathogenesis of Infectious

Keystone Symposia is pleased to present
The Innate Immune Response
in the Pathogenesis of Infectious Disease
Scientific Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes,
Anne O’Garra and Alan Sher
May 10–15, 2013 | Universidade Federal de Ouro Preto | Ouro Preto, Minas Gerais, Brazil

Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation
T
he rational development of immunological interventions
that are effective for treating or preventing infectious
diseases is still in its infancy. For decades, the majority
of studies on immunopathogenesis have dealt with physical
damage and inflammation, primarily mediated by lymphocytes.
In contrast, this Keystone Symposia meeting will:
> Focus on the interface of the innate immune system and
microbial pathogens and the role that innate immunity plays
in protective versus deleterious immune responses and,
thereby, in disease outcome;
> Promote discussion of fundamental concepts as well as
new advances in the role of innate immunity in host
resistance and pathogenesis of infectious diseases, with
special emphasis on infections of the tropics;
> Bring together investigators from different areas, such
as biochemistry, cell biology, immunology, microbiology,
parasitology, infectious diseases, tropical medicine and
biotechnology, to foster discussion of interdisciplinary
concepts and new directions for the field.
This is the first of a series of Keystone Symposia meetings
to be held in Brazil, and should foster the participation of
Latin American students and scientists. It is hoped the close
interaction of these participants with leading international
experts will lead to a stimulating atmosphere and ultimately
new South-North collaborations and research networks.
Session Topics:
> Innate Immune Recognition
> Innate Immunity in Vectors
> Innate Lymphoid Cells (ILC) and Mucosal Immunity
> Effector Mechanisms
> Innate Cytokines Influencing Adaptive Immunity
and Inflammation
> Innate Signals in Disease Pathogenesis
> Cell Death in Host Resistance and Pathogenesis
of Infectious Diseases
> Immunological Adjuvants and Vaccines
Global Health Travel Award Deadline: December 11, 2012
Abstract & Scholarship Deadline: January 7, 2013
Late-Breaking Abstract Deadline: February 4, 2013
Early Registration Deadline: March 5, 2013
1.970.262.1230 | 1.800.253.0685 (US & Canada)
Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization
headquartered in Colorado, USA directed and supported by the scientific community.
Note: Global Health Travel Awards are available to developing-country
investigators, who are eligible to receive an award for one meeting per calendar
year. Scholarships are available to students and postdoctoral fellows. Short talk
speakers will also be selected from abstracts. Early registration saves US$150 on
later fee. Information shown is subject to possible change.
www.keystonesymposia.org/13E1
Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
The Innate Immune Response in the Pathogenesis of Infectious Disease (E1)
May 10-15, 2013 • Centro de Artes e Convenções (UFOP) • Ouro Preto, MG, Brazil
Scientific Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher
Organized as an international collaboration and with generous support from CNPq — the National Council for Scientific and Technological Development, Brazil, and
FAPEMIG — Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill &
Melinda Gates Foundation.
Global Health Travel Award Deadline: December 11, 2012 / Abstract & Scholarship Deadline: January 7, 2013 / Late-Breaking Abstract Deadline: February 4, 2013 / Early Registration
Deadline: March 5, 2013
FRIDAY, MAY 10
Arrival and Registration
Welcome and Keynote Session
*Rodrigo Corrêa-Oliveira, FIOCRUZ, Brazil
Keystone Symposia Brazil and the Challenges of Global Tropical
Diseases
Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases
Sterling C. Eckard, University of Washington, USA
Intracellular Nucleic Acid Metabolism Limits the RIG-I-Mediated
Antiviral Response
Felix Meissner, Max Planck Institute of Biochemistry, Germany
Secretomics Defines How Proximal Adaptors of TLRs Regulate
Inflammation
Innate Immunity in Vectors
*Elena A. Levashina, Max Planck Institute for Infection Biology,
Germany
Mechanisms of Innate Resistance to Malaria Parasites in the Mosquito
SATURDAY, MAY 11
George Dimopoulos, Johns Hopkins University, USA
Innate Immune Recognition
Innate and Microbiota-Mediated Control of Dengue Virus in Mosquitoes
*Vishva M. Dixit, Genentech, Inc., USA
Simona Paro, IBMC-CNRS/Université de Strasbourg, France
Non-Canonical Inflammasome Activation Targets Caspase-11
Short Talk: Sensing Viral Nucleic Acids by the Innate Immune System:
Kate A. Fitzgerald, University of Massachusetts Medical School, USA Lessons from Drosophila
Regulation of Inflammatory Gene Expression by Long Noncoding
David L. Sacks, NIAID, National Institutes of Health, USA
RNAs
Influence of Vector Transmission on the Innate Immune Response to
Leishmania major
Julie Magarian Blander, Weill Cornell Medicine, Cornell University,
USA
Detecting and Responding to Microbial Viability
SUNDAY, MAY 12
Egil Lien, University of Massachusetts Medical School, USA
Innate Lymphoid Cells (ILC) and Mucosal Immunity
Short Talk: Innate Immunity to Plague
*Fiona M. Powrie, University of Oxford, UK
Sun Hur, Harvard Medical School, USA
IL-23-Driven Cellular and Molecular Pathways that Promote Intestinal
Short Talk: Molecular Mechanism for Viral dsRNA Detection by MDA5
Inflammation and Colon Cancer
Filaments
David Artis, Cornell University, USA
Jamie Lemon, University of Pennsylvania, USA
Regulation of Innate and Adaptive Immunity at Barrier Surfaces
Short Talk: Cytosolic Access and Sensing of Components of
Dan R. Littman, HHMI/New York University School of Medicine, USA
Extracellular Bacteria by Macrophages
Microbiota-Host Interactions in T Cell Homeostasis and Autoimmune
Poster Session 1
Disease
Marco Colonna, Washington University School of Medicine, USA
Workshop 1: Innate Recognition and Signaling
Innate Lymphoid Cells in Mucosal Immunity
*Marcelo T. Bozza, Universidade Federal do Rio de Janeiro, Brazil
Lucille Rankin, Walter and Eliza Hall Institute of Medical Research,
*Koichi S. Kobayashi, Texas A&M Health Science Center, USA
Australia
Jiaxi Wu, University of Texas Southwestern Medical Center, USA
Short Talk: T-bet Is Required for the Development of NKp46+ Innate
Identification of Cyclic-GMP-AMP (cGAMP) and Cyclic-GMP-AMP
Lymphoid Cells via a Notch Dependent Pathway
Synthase (cGAS) as Important Cytosolic DNA Sensing Mediators
Kevin J. Maloy, University of Oxford, UK
Andrea Puhar, Umeå University, Sweden
Nlrp3 Inflammasome Activation in the Intestinal Epithelium Protects
Shigella Effector IpgD Dampens Inflammation by Securing
Against a Mucosal Pathogen
Hemichannel Closing through Production of PdtIns5P, Thereby
Effector Mechanisms
Inhibiting Extracellular ATP-Mediated Endogenous Danger Signaling
Rune Hartmann, Aarhus University, Denmark
*Arturo Zychlinsky, Max Planck Institute for Infection Biology,
The Oligoadenylate Synthetase Like Protein (OASL) Enhances Viral
Germany
Recognition and Interferon Production by Infected Cells
NETs – From Infection to Autoimmunity
Warrison C. Andrade, UMass Medical School, USA
Judith E. Allen, University of Manchester, UK
Combined Action of Nucleic Acid-Sensing Toll-Like Receptors (TLRs)
Macrophages in Helminth Infection
and TLR11/TLR12 Heterodimers Imparts Host Resistance to
Jonathan Howard, Instituto Gulbenkian de Ciência, Portugal
Toxoplasma gondii
Genetic Basis of Innate Immune Control of a Parasitic Disease
Jane Rasaiyaah, University College London, UK
Dario S. Zamboni, University of São Paulo, Brazil
Inhibition of HIV-1-Cofactor Interactions Triggers Innate Sensors and
Short Talk: Inflammasome-Mediated Innate Immune Responses to
Interferon Secretion
Leishmania
Anamelia Lorenzetti Bocca, Universidade de Brasília, Brazil
Beta-Glucan Reverts the Macrophage Inability to Kill Cryptococcus
neoformans in vitro
* Session Chair † Invited but not yet accepted Program current as of June 18, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/13E1.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
The Innate Immune Response in the Pathogenesis of Infectious Disease (E1)
May 10-15, 2013 • Centro de Artes e Convenções (UFOP) • Ouro Preto, MG, Brazil
Scientific Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher
Organized as an international collaboration and with generous support from CNPq — the National Council for Scientific and Technological Development, Brazil, and
FAPEMIG — Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill &
Melinda Gates Foundation.
Global Health Travel Award Deadline: December 11, 2012 / Abstract & Scholarship Deadline: January 7, 2013 / Late-Breaking Abstract Deadline: February 4, 2013 / Early Registration
Deadline: March 5, 2013
Lynda M. Stuart, Bill & Melinda Gates Foundation, USA
Short Talk: Activation of Caspase-1 by the NLRP3 Inflammasome
Regulates NOX2 to Control Phagosome Function
Poster Session 2
MONDAY, MAY 13
Catherine L. Kennedy, University of Melbourne, Australia
Fas Signaling in Immune Defense Against the Intestinal Pathogen,
Citrobacter rodentium
Monica Macal, Five Prime Therapeutics, Inc, USA
TLR7 Is Required for Both Plasmacytoid Dendritic Cell IFN-I
Production and Subsequent Exhaustion during Chronic Viral Infection
Innate Cytokines Influencing Adaptive Immunity and Inflammation Innate Signals in Disease Pathogenesis
Zhijian James Chen, University of Texas Southwestern Medical
*Alan Sher, NIAID, National Institutes of Health, USA
Center, USA
TLR12: A New Player in Innate Recognition and Host Resistance to
Innate Immune Sensing and Signaling of Cytosolic DNA through a
Protozoan Infection
Cyclic Dinucleotide Pathway
Robert L. Coffman, Dynavax Technologies, USA
Douglas Golenbock, University of Massachusetts Medical School,
Clinical Applications of Innate Immune Signals
USA
Kingston H.G. Mills, Trinity College Dublin, Ireland
DNA Sensing Drives the Innate Immune Response in Malaria
Innate Determinates of Th1/Th17 versus Treg Cells
*Anne O'Garra, Francis Crick Institute, UK
Edgar M. Carvalho, Universidade Federal da Bahia, Brazil
The Immune Response in Tuberculosis: From Mouse Models to
Innate Determinants in the Control and Pathology of Human
Human Disease
Tegumentary Leishmaniasis
Corey A. Balinsky, NIAID, National Institutes of Health, USA
Katrijn Neyt, VIB, Ghent University, Belgium
Short Talk: NF45 Interacts with Dengue Virus Capsid Protein and
Short Talk: The Innate Cytokine IL-1alpha Is Necessary and Sufficient
Modulates Induction of Interferon Beta
for Formation of Tertiary Lymphoid Tissues following Influenza A Virus
Sergio Costa Oliveira, Universidade Federal de Minas Gerais, Brazil
Infection
Short Talk: Critical Role of ASC Inflammasomes and Bacterial Type IV
Andreas Wack, Francis Crick Institute, UK
Secretion System in Caspase-1 Activation and Host Innate
Short Talk: Pathogenic Potential of Type I IFN in Influenza Infection
Resistance to Brucella abortus Infection
Poster Session 3
TUESDAY, MAY 14
Workshop 2: Cytokines, Inflammation and Pathogenesis
*Sergio Costa Oliveira, Universidade Federal de Minas Gerais, Brazil Cell Death in Host Resistance and Pathogenesis of Infectious
Diseases
*Kevin J. Maloy, University of Oxford, UK
Douglas R. Green, St. Jude Children's Research Hospital, USA
David Sancho, CNIC-Fundación Centro Nacional de Investigaciones
Dead on Arrival: How Caspases Promote and Prevent Cell Death
Cardiovasculares, Spain
*Ricardo T. Gazzinelli, Fundação Oswaldo Cruz-CPqRR, Brazil
Recognition of Leishmania Parasites by the Macrophage-Inducible
NLRP12/NLRP3-Dependent Caspase-1 Driven Inflammation in Malaria
C-Type Lectin Mincle Subverts Adaptive Immunity and Promotes
Susceptibility to Infection
Maya Saleh, McGill University, Canada
cIAP2 Protects Mice from Alveolar Epithelial Injury during Influenza A
Jennifer Palomo, CNRS - INEM - UMR7355, France
Virus Infection
Type I Interferons Contribute to Orchestrate IFNgamma Dependent
Development of Experimental Cerebral Malaria
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital,
USA
Maria Bellio, Universidade Federal do Rio de Janeiro, Brazil
Inflammasome-Dependent and -Independent Regulation of IL-1
Intrinsic IL-18R1 Signaling Pathway Plays a Crucial Role in Th1 Cell
Cytokines in Inflammatory Disease
Expansion in Mice Infected with Trypanosoma cruzi
Karina R. Bortoluci, Federal University of São Paulo, Brazil
Catalina D. Alba Soto, Universidad de Buenos Aires, Argentina
Short Talk: Inflammasome-Independent Cell Death Induced by
Impairment of Natural Killer (NK) Cells Editing of Immature Dendritic
Cytosolic flagellin
Cells (DC) by Infection with a Virulent Trypanosoma cruzi Population
Edward A. Miao, University of North Carolina at Chapel Hill, USA
Gregory F. Sonnenberg, University of Pennsylvania, USA
Non-Canonical Inflammasome Activation of Caspase-11 Protects
Innate Lymphoid Cells Are Critical Regulators of Host Immune
Against Cytosolic Bacteria
Responses to Bacteria and Intestinal Homeostasis
Mohamed Lamkanfi, Ghent University, Belgium
Shie-Liang Hsieh, Academia Sinica, Taiwan
Short Talk: Regulation of Nlrp3 Inflammasome Activation by the
C-Type Lectin 5A (CLEC5A) Is Critical for the Pathogenesis of
Ubiquitin-Editing Enzyme A20
Flaviviral Infections
Workshop 3: Cell Death and Pathogenesis
*Gustavo P. Amarante-Mendes, Universidade de São Paulo, Brazil
*Clare E. Bryant, University of Cambridge, UK
A Critical Link between Innate Immunity and Cellular Mechanics to
Control Bacterial Load in Macrophages
* Session Chair † Invited but not yet accepted Program current as of June 18, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/13E1.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
The Innate Immune Response in the Pathogenesis of Infectious Disease (E1)
May 10-15, 2013 • Centro de Artes e Convenções (UFOP) • Ouro Preto, MG, Brazil
Scientific Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher
Organized as an international collaboration and with generous support from CNPq — the National Council for Scientific and Technological Development, Brazil, and
FAPEMIG — Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill &
Melinda Gates Foundation.
Global Health Travel Award Deadline: December 11, 2012 / Abstract & Scholarship Deadline: January 7, 2013 / Late-Breaking Abstract Deadline: February 4, 2013 / Early Registration
Deadline: March 5, 2013
Petr Broz, Biozentrum, University of Basel, Switzerland
Caspase-11 Increases Susceptibility to Salmonella Infection in the
Absence of Caspase-1
William J. Kaiser, Emory University School of Medicine, USA
Virus Inhibition of Caspase 8 Restricts Pathogenesis via
RIP3-Dependent Programmed Necrosis
Marco A. Ataíde, Universidade Federal de Minas Gerais, Brazil
CD14dimCD16+ Monocytes Are a Main Source of Active Caspase-1
and IL-1beta Release during Plasmodium vivax Malaria
Vijay Pancholi, Ohio State University College of Medicine, USA
Group A Streptococcus Ser/Thr Phosphatase-Mediated Apoptosis of
Human Respiratory Cells
Mordechay Gerlic, Sackler Faculty of Medicine, Tel Aviv University,
Israel
EBV-miR-BART15 Regulates the Nlrp3 Inflammasome and IL-1beta
Production
Ivan Tattoli, University of Toronto, Canada
mTOR Signaling and Metabolic Stress Response Pathways in the
Host Response to Intracellular Bacteria
Larissa Dias Cunha, Universidade de São Paulo, Brazil
Coxiella burnetii Inhibits Inflammasome Activation through a
Dot/Icm-Dependent Effector Protein
Immunological Adjuvants and Vaccines
*Jorge Kalil, Instituto Butantan, Brazil
Dengue Vaccine Candidates
Jacques F. Banchereau, The Jackson Laboratory for Genomic
Medicine, USA
Harnessing Human Dendritic Cell Subsets and Follicular Helper T Cell
Subsets for Next Generation Vaccines
Closing Keynote Address
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Targeting Dendritic Cells in Malaria Vaccine
WEDNESDAY, MAY 15
Departure
* Session Chair † Invited but not yet accepted Program current as of June 18, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/13E1.