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Keystone Symposia is pleased to present The Innate Immune Response in the Pathogenesis of Infectious Disease Scientific Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O’Garra and Alan Sher May 10–15, 2013 | Universidade Federal de Ouro Preto | Ouro Preto, Minas Gerais, Brazil Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation T he rational development of immunological interventions that are effective for treating or preventing infectious diseases is still in its infancy. For decades, the majority of studies on immunopathogenesis have dealt with physical damage and inflammation, primarily mediated by lymphocytes. In contrast, this Keystone Symposia meeting will: > Focus on the interface of the innate immune system and microbial pathogens and the role that innate immunity plays in protective versus deleterious immune responses and, thereby, in disease outcome; > Promote discussion of fundamental concepts as well as new advances in the role of innate immunity in host resistance and pathogenesis of infectious diseases, with special emphasis on infections of the tropics; > Bring together investigators from different areas, such as biochemistry, cell biology, immunology, microbiology, parasitology, infectious diseases, tropical medicine and biotechnology, to foster discussion of interdisciplinary concepts and new directions for the field. This is the first of a series of Keystone Symposia meetings to be held in Brazil, and should foster the participation of Latin American students and scientists. It is hoped the close interaction of these participants with leading international experts will lead to a stimulating atmosphere and ultimately new South-North collaborations and research networks. Session Topics: > Innate Immune Recognition > Innate Immunity in Vectors > Innate Lymphoid Cells (ILC) and Mucosal Immunity > Effector Mechanisms > Innate Cytokines Influencing Adaptive Immunity and Inflammation > Innate Signals in Disease Pathogenesis > Cell Death in Host Resistance and Pathogenesis of Infectious Diseases > Immunological Adjuvants and Vaccines Global Health Travel Award Deadline: December 11, 2012 Abstract & Scholarship Deadline: January 7, 2013 Late-Breaking Abstract Deadline: February 4, 2013 Early Registration Deadline: March 5, 2013 1.970.262.1230 | 1.800.253.0685 (US & Canada) Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community. Note: Global Health Travel Awards are available to developing-country investigators, who are eligible to receive an award for one meeting per calendar year. Scholarships are available to students and postdoctoral fellows. Short talk speakers will also be selected from abstracts. Early registration saves US$150 on later fee. Information shown is subject to possible change. www.keystonesymposia.org/13E1 Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community. KEYSTONE SYMPOSIA on Molecular and Cellular Biology The Innate Immune Response in the Pathogenesis of Infectious Disease (E1) May 10-15, 2013 • Centro de Artes e Convenções (UFOP) • Ouro Preto, MG, Brazil Scientific Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher Organized as an international collaboration and with generous support from CNPq — the National Council for Scientific and Technological Development, Brazil, and FAPEMIG — Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation. Global Health Travel Award Deadline: December 11, 2012 / Abstract & Scholarship Deadline: January 7, 2013 / Late-Breaking Abstract Deadline: February 4, 2013 / Early Registration Deadline: March 5, 2013 FRIDAY, MAY 10 Arrival and Registration Welcome and Keynote Session *Rodrigo Corrêa-Oliveira, FIOCRUZ, Brazil Keystone Symposia Brazil and the Challenges of Global Tropical Diseases Jean-Laurent Casanova, Rockefeller University, USA Toward a Genetic Theory of Infectious Diseases Sterling C. Eckard, University of Washington, USA Intracellular Nucleic Acid Metabolism Limits the RIG-I-Mediated Antiviral Response Felix Meissner, Max Planck Institute of Biochemistry, Germany Secretomics Defines How Proximal Adaptors of TLRs Regulate Inflammation Innate Immunity in Vectors *Elena A. Levashina, Max Planck Institute for Infection Biology, Germany Mechanisms of Innate Resistance to Malaria Parasites in the Mosquito SATURDAY, MAY 11 George Dimopoulos, Johns Hopkins University, USA Innate Immune Recognition Innate and Microbiota-Mediated Control of Dengue Virus in Mosquitoes *Vishva M. Dixit, Genentech, Inc., USA Simona Paro, IBMC-CNRS/Université de Strasbourg, France Non-Canonical Inflammasome Activation Targets Caspase-11 Short Talk: Sensing Viral Nucleic Acids by the Innate Immune System: Kate A. Fitzgerald, University of Massachusetts Medical School, USA Lessons from Drosophila Regulation of Inflammatory Gene Expression by Long Noncoding David L. Sacks, NIAID, National Institutes of Health, USA RNAs Influence of Vector Transmission on the Innate Immune Response to Leishmania major Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA Detecting and Responding to Microbial Viability SUNDAY, MAY 12 Egil Lien, University of Massachusetts Medical School, USA Innate Lymphoid Cells (ILC) and Mucosal Immunity Short Talk: Innate Immunity to Plague *Fiona M. Powrie, University of Oxford, UK Sun Hur, Harvard Medical School, USA IL-23-Driven Cellular and Molecular Pathways that Promote Intestinal Short Talk: Molecular Mechanism for Viral dsRNA Detection by MDA5 Inflammation and Colon Cancer Filaments David Artis, Cornell University, USA Jamie Lemon, University of Pennsylvania, USA Regulation of Innate and Adaptive Immunity at Barrier Surfaces Short Talk: Cytosolic Access and Sensing of Components of Dan R. Littman, HHMI/New York University School of Medicine, USA Extracellular Bacteria by Macrophages Microbiota-Host Interactions in T Cell Homeostasis and Autoimmune Poster Session 1 Disease Marco Colonna, Washington University School of Medicine, USA Workshop 1: Innate Recognition and Signaling Innate Lymphoid Cells in Mucosal Immunity *Marcelo T. Bozza, Universidade Federal do Rio de Janeiro, Brazil Lucille Rankin, Walter and Eliza Hall Institute of Medical Research, *Koichi S. Kobayashi, Texas A&M Health Science Center, USA Australia Jiaxi Wu, University of Texas Southwestern Medical Center, USA Short Talk: T-bet Is Required for the Development of NKp46+ Innate Identification of Cyclic-GMP-AMP (cGAMP) and Cyclic-GMP-AMP Lymphoid Cells via a Notch Dependent Pathway Synthase (cGAS) as Important Cytosolic DNA Sensing Mediators Kevin J. Maloy, University of Oxford, UK Andrea Puhar, Umeå University, Sweden Nlrp3 Inflammasome Activation in the Intestinal Epithelium Protects Shigella Effector IpgD Dampens Inflammation by Securing Against a Mucosal Pathogen Hemichannel Closing through Production of PdtIns5P, Thereby Effector Mechanisms Inhibiting Extracellular ATP-Mediated Endogenous Danger Signaling Rune Hartmann, Aarhus University, Denmark *Arturo Zychlinsky, Max Planck Institute for Infection Biology, The Oligoadenylate Synthetase Like Protein (OASL) Enhances Viral Germany Recognition and Interferon Production by Infected Cells NETs – From Infection to Autoimmunity Warrison C. Andrade, UMass Medical School, USA Judith E. Allen, University of Manchester, UK Combined Action of Nucleic Acid-Sensing Toll-Like Receptors (TLRs) Macrophages in Helminth Infection and TLR11/TLR12 Heterodimers Imparts Host Resistance to Jonathan Howard, Instituto Gulbenkian de Ciência, Portugal Toxoplasma gondii Genetic Basis of Innate Immune Control of a Parasitic Disease Jane Rasaiyaah, University College London, UK Dario S. Zamboni, University of São Paulo, Brazil Inhibition of HIV-1-Cofactor Interactions Triggers Innate Sensors and Short Talk: Inflammasome-Mediated Innate Immune Responses to Interferon Secretion Leishmania Anamelia Lorenzetti Bocca, Universidade de Brasília, Brazil Beta-Glucan Reverts the Macrophage Inability to Kill Cryptococcus neoformans in vitro * Session Chair † Invited but not yet accepted Program current as of June 18, 2017. Program subject to change. Meal formats are based on meeting venue. For the most up-to-date details, visit www.keystonesymposia.org/13E1. KEYSTONE SYMPOSIA on Molecular and Cellular Biology The Innate Immune Response in the Pathogenesis of Infectious Disease (E1) May 10-15, 2013 • Centro de Artes e Convenções (UFOP) • Ouro Preto, MG, Brazil Scientific Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher Organized as an international collaboration and with generous support from CNPq — the National Council for Scientific and Technological Development, Brazil, and FAPEMIG — Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation. Global Health Travel Award Deadline: December 11, 2012 / Abstract & Scholarship Deadline: January 7, 2013 / Late-Breaking Abstract Deadline: February 4, 2013 / Early Registration Deadline: March 5, 2013 Lynda M. Stuart, Bill & Melinda Gates Foundation, USA Short Talk: Activation of Caspase-1 by the NLRP3 Inflammasome Regulates NOX2 to Control Phagosome Function Poster Session 2 MONDAY, MAY 13 Catherine L. Kennedy, University of Melbourne, Australia Fas Signaling in Immune Defense Against the Intestinal Pathogen, Citrobacter rodentium Monica Macal, Five Prime Therapeutics, Inc, USA TLR7 Is Required for Both Plasmacytoid Dendritic Cell IFN-I Production and Subsequent Exhaustion during Chronic Viral Infection Innate Cytokines Influencing Adaptive Immunity and Inflammation Innate Signals in Disease Pathogenesis Zhijian James Chen, University of Texas Southwestern Medical *Alan Sher, NIAID, National Institutes of Health, USA Center, USA TLR12: A New Player in Innate Recognition and Host Resistance to Innate Immune Sensing and Signaling of Cytosolic DNA through a Protozoan Infection Cyclic Dinucleotide Pathway Robert L. Coffman, Dynavax Technologies, USA Douglas Golenbock, University of Massachusetts Medical School, Clinical Applications of Innate Immune Signals USA Kingston H.G. Mills, Trinity College Dublin, Ireland DNA Sensing Drives the Innate Immune Response in Malaria Innate Determinates of Th1/Th17 versus Treg Cells *Anne O'Garra, Francis Crick Institute, UK Edgar M. Carvalho, Universidade Federal da Bahia, Brazil The Immune Response in Tuberculosis: From Mouse Models to Innate Determinants in the Control and Pathology of Human Human Disease Tegumentary Leishmaniasis Corey A. Balinsky, NIAID, National Institutes of Health, USA Katrijn Neyt, VIB, Ghent University, Belgium Short Talk: NF45 Interacts with Dengue Virus Capsid Protein and Short Talk: The Innate Cytokine IL-1alpha Is Necessary and Sufficient Modulates Induction of Interferon Beta for Formation of Tertiary Lymphoid Tissues following Influenza A Virus Sergio Costa Oliveira, Universidade Federal de Minas Gerais, Brazil Infection Short Talk: Critical Role of ASC Inflammasomes and Bacterial Type IV Andreas Wack, Francis Crick Institute, UK Secretion System in Caspase-1 Activation and Host Innate Short Talk: Pathogenic Potential of Type I IFN in Influenza Infection Resistance to Brucella abortus Infection Poster Session 3 TUESDAY, MAY 14 Workshop 2: Cytokines, Inflammation and Pathogenesis *Sergio Costa Oliveira, Universidade Federal de Minas Gerais, Brazil Cell Death in Host Resistance and Pathogenesis of Infectious Diseases *Kevin J. Maloy, University of Oxford, UK Douglas R. Green, St. Jude Children's Research Hospital, USA David Sancho, CNIC-Fundación Centro Nacional de Investigaciones Dead on Arrival: How Caspases Promote and Prevent Cell Death Cardiovasculares, Spain *Ricardo T. Gazzinelli, Fundação Oswaldo Cruz-CPqRR, Brazil Recognition of Leishmania Parasites by the Macrophage-Inducible NLRP12/NLRP3-Dependent Caspase-1 Driven Inflammation in Malaria C-Type Lectin Mincle Subverts Adaptive Immunity and Promotes Susceptibility to Infection Maya Saleh, McGill University, Canada cIAP2 Protects Mice from Alveolar Epithelial Injury during Influenza A Jennifer Palomo, CNRS - INEM - UMR7355, France Virus Infection Type I Interferons Contribute to Orchestrate IFNgamma Dependent Development of Experimental Cerebral Malaria Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA Maria Bellio, Universidade Federal do Rio de Janeiro, Brazil Inflammasome-Dependent and -Independent Regulation of IL-1 Intrinsic IL-18R1 Signaling Pathway Plays a Crucial Role in Th1 Cell Cytokines in Inflammatory Disease Expansion in Mice Infected with Trypanosoma cruzi Karina R. Bortoluci, Federal University of São Paulo, Brazil Catalina D. Alba Soto, Universidad de Buenos Aires, Argentina Short Talk: Inflammasome-Independent Cell Death Induced by Impairment of Natural Killer (NK) Cells Editing of Immature Dendritic Cytosolic flagellin Cells (DC) by Infection with a Virulent Trypanosoma cruzi Population Edward A. Miao, University of North Carolina at Chapel Hill, USA Gregory F. Sonnenberg, University of Pennsylvania, USA Non-Canonical Inflammasome Activation of Caspase-11 Protects Innate Lymphoid Cells Are Critical Regulators of Host Immune Against Cytosolic Bacteria Responses to Bacteria and Intestinal Homeostasis Mohamed Lamkanfi, Ghent University, Belgium Shie-Liang Hsieh, Academia Sinica, Taiwan Short Talk: Regulation of Nlrp3 Inflammasome Activation by the C-Type Lectin 5A (CLEC5A) Is Critical for the Pathogenesis of Ubiquitin-Editing Enzyme A20 Flaviviral Infections Workshop 3: Cell Death and Pathogenesis *Gustavo P. Amarante-Mendes, Universidade de São Paulo, Brazil *Clare E. Bryant, University of Cambridge, UK A Critical Link between Innate Immunity and Cellular Mechanics to Control Bacterial Load in Macrophages * Session Chair † Invited but not yet accepted Program current as of June 18, 2017. Program subject to change. Meal formats are based on meeting venue. For the most up-to-date details, visit www.keystonesymposia.org/13E1. KEYSTONE SYMPOSIA on Molecular and Cellular Biology The Innate Immune Response in the Pathogenesis of Infectious Disease (E1) May 10-15, 2013 • Centro de Artes e Convenções (UFOP) • Ouro Preto, MG, Brazil Scientific Organizers: Ricardo T. Gazzineli, Gustavo P. Amarante-Mendes, Anne O'Garra and Alan Sher Organized as an international collaboration and with generous support from CNPq — the National Council for Scientific and Technological Development, Brazil, and FAPEMIG — Minas Gerais State Agency for Research Development. Part of the Keystone Symposia Global Health Series, travel awards supported by the Bill & Melinda Gates Foundation. Global Health Travel Award Deadline: December 11, 2012 / Abstract & Scholarship Deadline: January 7, 2013 / Late-Breaking Abstract Deadline: February 4, 2013 / Early Registration Deadline: March 5, 2013 Petr Broz, Biozentrum, University of Basel, Switzerland Caspase-11 Increases Susceptibility to Salmonella Infection in the Absence of Caspase-1 William J. Kaiser, Emory University School of Medicine, USA Virus Inhibition of Caspase 8 Restricts Pathogenesis via RIP3-Dependent Programmed Necrosis Marco A. Ataíde, Universidade Federal de Minas Gerais, Brazil CD14dimCD16+ Monocytes Are a Main Source of Active Caspase-1 and IL-1beta Release during Plasmodium vivax Malaria Vijay Pancholi, Ohio State University College of Medicine, USA Group A Streptococcus Ser/Thr Phosphatase-Mediated Apoptosis of Human Respiratory Cells Mordechay Gerlic, Sackler Faculty of Medicine, Tel Aviv University, Israel EBV-miR-BART15 Regulates the Nlrp3 Inflammasome and IL-1beta Production Ivan Tattoli, University of Toronto, Canada mTOR Signaling and Metabolic Stress Response Pathways in the Host Response to Intracellular Bacteria Larissa Dias Cunha, Universidade de São Paulo, Brazil Coxiella burnetii Inhibits Inflammasome Activation through a Dot/Icm-Dependent Effector Protein Immunological Adjuvants and Vaccines *Jorge Kalil, Instituto Butantan, Brazil Dengue Vaccine Candidates Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA Harnessing Human Dendritic Cell Subsets and Follicular Helper T Cell Subsets for Next Generation Vaccines Closing Keynote Address Michel C. Nussenzweig, HHMI/Rockefeller University, USA Targeting Dendritic Cells in Malaria Vaccine WEDNESDAY, MAY 15 Departure * Session Chair † Invited but not yet accepted Program current as of June 18, 2017. Program subject to change. Meal formats are based on meeting venue. For the most up-to-date details, visit www.keystonesymposia.org/13E1.