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http://www.rub.de/homeexpneu/lehre/biochemie/vorlesungen.html.de Immunology Introduction 13.04.2016, Ruhr-Universität Bochum Marcus Peters, [email protected] Figure 1-23 The birth-hour of vaccination Vaccination Edward Jenner (1749-1823) Wellcome Library, London Protection against Smallpox! Cowpox (Variola vaccinae) on the udder Figure 1-2 Figure 1-33 Subacute sclerosing panencephalitis (SSPE) Introduction to the key players of the Immune System Figure 1-4 part 1 of 3 Figure 1-4 part 2 of 3 Figure 1-4 part 3 of 3 Figure 1-6 Figure 1-4 part 3 ofantigen 3 presentation, production of Antibodies (plasma cell) Killing of infected cells, activation of other immune cells The immune cells (leukocytes) and their precursors Figure 1-3 The immune cells are organized in the lymphatic system Figure 1-7 yellow: primary lymph tissue blue: secondary lymph tissue The circulation of lymphocytes through the body Figure 1-11 Figure 1-8 part 1 of 2 Histologic appearance of a lymph node Figure 1-8 part 2 of 2 Figure 1-9 part 1 of 3 red pulp white pulp Figure 1-9 part 2 of 3 PALS= periarterial lymphatic sheaths HEV permit the entry of lymphocytes into the paracortex 1= macrophage 2= lymphocytes 3= HEV 4= lymph vessels Wikipedia.de HEV= venules with high endothelium Peyer´s Patches Figure 1-10 Activation of an innate immune response at sites of infection results in inflammation Figure 1-12 dendritic cell Cytokines = small proteins that can act in an autocrine, endocrine or paracrine manner „hormones of the immune system“ Chemokines = Cytokines with chemotactic activity Activation of an adaptive immune response in the lymph node Figure 1-13 HEV= venules with high endothelium Clonal expansion of antigen specific lymphocytes in lymph nodes Figure 1-14 part 2 of 2 Clonal selection of lymphocytes Each lymphocyte from the T- and B-cell lineage bears a receptor with a unique specificity The structure of antibodies variable region (paratope) Epitop The different effector function of antibodies Figure 1-24 The biphasic response to antigens Figure 1-20 Antigen presenting cells Figure 1-22 Antigen presenting molecules Figure 1-27 Presentation of peptides on MHC I molecules Figure 1-28 Presentation of peptides on MHC II molecules Figure 1-29 The activation of effector T-lymphocytes Figure 1-21 The effector function of cytotoxic T-cells Figure 1-30 The effector function of helper T-cells (Th1) Figure 1-31 The effector function of helper T-cells (Th2) The chapters refer to “Janeway's Immunobiology (Englisch) Taschenbuch – 1. August 2011” Topic 1: Complement system (Prof. Bufe) - 01.06.16 1. General features of CS (Janeway 48-50); Central role of C3 convertase (Janeway 50-52); Lectin, classical and alternative pathway (Janeway 52-59) 2. Activation of membrane attacking complex; effects and regulation of complement factors; Role of complement receptors; role of small fragments (Janeway 59-71) Topic 2: Immunological methods (Dr. Peters) - 08.06.16 1. Immunization & the detection, measurement and characterization of antibodies; their use as research and diagnostic tools (Janeway Page 717-739) 2. The isolation and characterization of lymphocytes & the detection of immunity in vivo (Janeway Page 739-762) Topic 3: Immune response to infection (Prof. Bufe) - 22.06.16 1. Phases of infection (Janeway 430, 11.1); Role of innate immune response for adaptive response (Janeway 432; 11.2); Cytokines and different T-cell subsets in response to different pathogens (Janeway 434-439; 11.3-11.5) 2. Homing of T-cells and direct CD8 T-cell action (Janeway 439-443, 11.6-11.8); Antibody response in infection (Janeway 444-448, 11.9-11.12) Topic 4: Manipulation of the immune response (Dr. Peters) 29.06.16 1. Autoimmune diseases and the pathogenic mechanism (Janeway Page 622-638). Treatment of unwanted immune responses (Janeway Page 669-682) 2. The immune response to tumors & fighting infectious diseases with vaccination (Janeway Page 682-710) Topic 5: Allergy and allergic diseases (Prof. Raulf) 06.07.16 1. IgE and IgE-mediated diseases (Janeway Page 573592) 2. Non-IgE-mediated allergic diseases (Janeway Page 598-606)