Download lymphatic - Ruhr-Universität Bochum

http://www.rub.de/homeexpneu/lehre/biochemie/vorlesungen.html.de
Immunology
Introduction
13.04.2016, Ruhr-Universität Bochum
Marcus Peters, [email protected]
Figure 1-23
The birth-hour of vaccination
Vaccination
Edward Jenner (1749-1823)
Wellcome Library, London
Protection against
Smallpox!
Cowpox
(Variola
vaccinae)
on the
udder
Figure 1-2
Figure 1-33
Subacute sclerosing
panencephalitis (SSPE)
Introduction to the key players
of the Immune System
Figure 1-4 part 1 of 3
Figure 1-4 part 2 of 3
Figure 1-4 part 3 of 3
Figure 1-6
Figure 1-4 part 3 ofantigen
3
presentation,
production of
Antibodies
(plasma cell)
Killing of
infected
cells,
activation of
other
immune cells
The immune cells (leukocytes) and their precursors
Figure 1-3
The immune cells are organized in the lymphatic system
Figure 1-7
yellow: primary lymph tissue
blue: secondary lymph tissue
The circulation of lymphocytes through the body
Figure 1-11
Figure 1-8 part 1 of 2
Histologic appearance of a lymph node
Figure 1-8 part 2 of 2
Figure 1-9 part 1 of 3
red pulp
white pulp
Figure 1-9 part 2 of 3
PALS= periarterial lymphatic sheaths
HEV permit the entry of lymphocytes into the paracortex
1= macrophage
2= lymphocytes
3= HEV
4= lymph vessels
Wikipedia.de
HEV= venules with high endothelium
Peyer´s Patches
Figure 1-10
Activation of an innate immune response at sites of infection
results in inflammation
Figure 1-12
dendritic
cell
Cytokines = small proteins that can act in an autocrine, endocrine
or paracrine manner „hormones of the immune system“
Chemokines = Cytokines with chemotactic activity
Activation of an adaptive immune response in the lymph node
Figure 1-13
HEV= venules with high endothelium
Clonal expansion of antigen specific lymphocytes in lymph nodes
Figure 1-14 part 2 of 2
Clonal selection of lymphocytes
Each lymphocyte from the T- and B-cell lineage bears a receptor with a unique specificity
The structure of antibodies
variable region (paratope)
Epitop
The different effector function of antibodies
Figure 1-24
The biphasic response to antigens
Figure 1-20
Antigen presenting cells
Figure 1-22
Antigen presenting molecules
Figure 1-27
Presentation of peptides on MHC I molecules
Figure 1-28
Presentation of peptides on MHC II molecules
Figure 1-29
The activation of effector T-lymphocytes
Figure 1-21
The effector function of cytotoxic T-cells
Figure 1-30
The effector function of helper T-cells (Th1)
Figure 1-31
The effector function of helper T-cells (Th2)
The chapters refer to “Janeway's Immunobiology (Englisch)
Taschenbuch – 1. August 2011”
Topic 1: Complement system (Prof. Bufe) - 01.06.16
1. General features of CS (Janeway 48-50); Central role of C3
convertase (Janeway 50-52); Lectin, classical and alternative
pathway (Janeway 52-59)
2. Activation of membrane attacking complex; effects and
regulation of complement factors; Role of complement
receptors; role of small fragments (Janeway 59-71)
Topic 2: Immunological methods (Dr. Peters) - 08.06.16
1. Immunization & the detection, measurement and
characterization of antibodies; their use as research and
diagnostic tools (Janeway Page 717-739)
2. The isolation and characterization of lymphocytes & the
detection of immunity in vivo (Janeway Page 739-762)
Topic 3: Immune response to infection (Prof. Bufe) - 22.06.16
1. Phases of infection (Janeway 430, 11.1); Role of innate
immune response for adaptive response (Janeway 432;
11.2); Cytokines and different T-cell subsets in response to
different pathogens (Janeway 434-439; 11.3-11.5)
2. Homing of T-cells and direct CD8 T-cell action (Janeway
439-443, 11.6-11.8); Antibody response in infection
(Janeway 444-448, 11.9-11.12)
Topic 4: Manipulation of the immune response (Dr. Peters) 29.06.16
1. Autoimmune diseases and the pathogenic mechanism
(Janeway Page 622-638). Treatment of unwanted immune
responses (Janeway Page 669-682)
2. The immune response to tumors & fighting infectious diseases
with vaccination (Janeway Page 682-710)
Topic 5: Allergy and allergic diseases (Prof. Raulf) 06.07.16
1. IgE and IgE-mediated diseases (Janeway Page 573592)
2. Non-IgE-mediated allergic diseases (Janeway Page
598-606)