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Download COURSE SYLLABUS CHM 521 Biochemistry I 3(3
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Central Michigan University College of Arts & Sciences Master Course Syllabus CHM 521 Desig. No. I. Biochemistry I Title 3(3-0) Credit (Mode) Bulletin Description: The chemistry of biomolecules with emphasis on the structure and function of proteins, enzymes, carbohydrates, lipids, and nucleotides, carbohydrate metabolism. II. Prerequisites: CHM 211 and 346 III. Rationale for course level: CHM 521 is an advanced chemistry course which requires a broad background in chemistry. Since biochemistry is not required at the undergraduate level, many graduate students have not taken this course as an undergraduate. Therefore, it is appropriate to offer this course at the 500 level so that graduate students may also get credit for the course. IV. Textbooks and other materials to be furnished by the student: Required textbook: any of several comprehensive biochemistry textbooks may be used. An example is Principles of Biochemistry, 2nd edition, by Lehninger, Nelson, and Cox, Worth Publishers, 1993. Optional supplement: some publishers provide a student study guide to go with the required textbook. V. Special requirements for the course: none VI. General methodology used in conducting the course: The course consists of lectures over assigned reading, discussion of subject matter, and homework problems. VII. Course objectives: 1. Learn the structural formulas of carbohydrates, nucleotides, amino acids, and lipids. 2. Learn the four levels of protein structure. 3. Learn the functions of proteins and lipids. 4. Learn enzyme nomenclature, catalysis, kinetics, inhibition, and regulation. 5. Learn the function of vitamins and metal ion cofactors. 6. Learn the function of ATP in bioenergetics. 7. Learn the sequence of reactions in the following pathways of carbohydrate metabolism: glycolysis, gluconeogenesis, pentose phosphate pathway, citric acid cycle, glyoxylate cycle, electron transport, and oxidative phosphorylation. 8. Learn the mechanisms of regulation of carbohydrate metabolism by hormones and metabolites. VIII. Course outline: SCHEDULE OF LECTURES Week 1 2 3 4 5 6 7 8 Subject Introduction to biochemistry; cells Water and buffers Structure of carbohydrates Nucleotide structure Amino acid structure Amino acid properties and peptides Protein function and classification Protein purification and sequencing Structure of fibrous proteins; collagen Structure of globular proteins Hemoglobin and immunoglobulins Enzyme nomenclature Vitamin coenzymes Enzyme kinetics Enzyme inhibition Enzyme catalysis Control of enzyme activity Zymogens and blood clotting Lipid structure and nomenclature Structure of membranes Membrane transport 9 10 11 12 13 14 15 16 IX. Introduction to metabolic pathways Bioenergetics and coupled reactions ATP and phosphate transfer The first stage of glycolysis The second stage of glycolysis Gluconeogenesis The pentose phosphate pathway Glycogen breakdown and synthesis Regulation of carbohydrate metabolism Hormones and second messengers Oxidation of pyruvate The citric acid cycle Anabolic TCA cycle and glyoxylate cycle Regulation of the citric acid cycle Di- and oligosaccharide metabolism Mitochondria and redox reactions The electron-transport chain complexes Oxidative phosphorylation Mitochondrial shuttles Final examination, comprehensive Evaluation: Three monthly examinations (60 % of course grade) and a comprehensive final examination (40 % of course grade). GRADING Each monthly examination will be 100 points. Copies of old examinations are on reserve on the first floor of Park Library. The comprehensive final examination is 200 points. Copies of old final examinations are not on reserve. The grades are determined on a percentage basis. Pluses and minuses are given to those on the upper and lower ends of each grade range. Grading Scale: 90-100% 80-89% 60-79% 50-59% 0-49% A B C E Examinations must be taken during the scheduled time unless prior arrangements have been made to take the examination early. No make-up examinations will be given. An excused absence from one test will not effect your course grade. An unexcused absence will result in a score of zero for that examination. The requirements for undergraduates and graduates students are identical. X. Bibliography: Textbooks: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. Biochemistry by Stryer (4th edition), Freeman and Co., 1995 Principles of Biochemistry by Horton, et al, Neil Patterson Publishers, 1993 Biochemistry by Rawn, Neil Patterson Publishers, 1989 Biochemistry by Voet and Voet, (2nd edition), John Wiley & Sons, 1995 Biochemistry by Zubay (3rd edition), Wm. C. Brown Publishers, 1993 Harper's Biochemistry by Martin, et al (23rd edition), Lange Medical Publications, 1991 Biochemistry by Garrett and Grisham, Saunders College Publishing, 1995 Biochemistry by Kuchel and Ralston (Shaum's Outline Series), McGraw-Hill Book Company, 1988 Biochemistry by Devlin, (3rd edition), John Wiley & Sons, Inc., 1992 Biochemistry by Abeles, et al, Jones and Bartlett Publishers, l9g2 Modern Concepts in Biochemistry by Bohinski, (5th edition), Allyn and Bacon, Inc., 1987 Biochemistry by Mathews and van Holde, Benjamin/Cummings Publishing Company, 1990 References: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. Annual Review of Biochemistry CRC Handbook of Biochemistry Comprehensive Biochemistry Methods in Enzymology Advances in Enzymology Advances in Enzyme Regulation The Enzymes Vitamins and Hormones Advances in Protein Chemistry The Proteins Advances in Lipid Research Progress in Nucleic Acid Research and Molecular Biology Periodicals: 1. 2. 3. 4. 5. 6. Science Chemical and Engineering News Nature Scientific American Science News Trends in Biological Sciences Abstracts: 1. 2. Chemical Abstracts Biological Abstracts Titles: 1. 2. 3. 4. Current Contents Index Medicus Biological and Agricultural Index Chemical Titles Journals: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Journal of Biological Chemistry Proceedings of the National Academy of Science Biochemistry Biochemistry Journal International Journal of Biochemistry Archives of Biochemistry and Biophysics Biochimica et Biophysica Acta Analytical Biochemistry Biochemistry and Biophysics Research Communication Canadian Journal of Biochemistry and Cell Biology Syllabus Prepared By: Calvin Tormanen Name December 1, 1995 Date