Download COURSE SYLLABUS CHM 521 Biochemistry I 3(3

Central Michigan University
College of Arts & Sciences Master
Course Syllabus
CHM 521
Desig. No.
I.
Biochemistry I
Title
3(3-0)
Credit (Mode)
Bulletin Description:
The chemistry of biomolecules with emphasis on the structure and function of proteins,
enzymes, carbohydrates, lipids, and nucleotides, carbohydrate metabolism.
II.
Prerequisites:
CHM 211 and 346
III.
Rationale for course level:
CHM 521 is an advanced chemistry course which requires a broad background in
chemistry. Since biochemistry is not required at the undergraduate level, many graduate
students have not taken this course as an undergraduate. Therefore, it is appropriate to
offer this course at the 500 level so that graduate students may also get credit for the
course.
IV.
Textbooks and other materials to be furnished by the student:
Required textbook: any of several comprehensive biochemistry textbooks may be used.
An example is Principles of Biochemistry, 2nd edition, by Lehninger, Nelson, and Cox,
Worth Publishers, 1993.
Optional supplement: some publishers provide a student study guide to go with the
required textbook.
V.
Special requirements for the course:
none
VI.
General methodology used in conducting the course:
The course consists of lectures over assigned reading, discussion of subject matter, and
homework problems.
VII.
Course objectives:
1.
Learn the structural formulas of carbohydrates, nucleotides, amino acids, and
lipids.
2.
Learn the four levels of protein structure.
3.
Learn the functions of proteins and lipids.
4.
Learn enzyme nomenclature, catalysis, kinetics, inhibition, and regulation.
5.
Learn the function of vitamins and metal ion cofactors.
6.
Learn the function of ATP in bioenergetics.
7.
Learn the sequence of reactions in the following pathways of carbohydrate
metabolism: glycolysis, gluconeogenesis, pentose phosphate pathway, citric acid
cycle, glyoxylate cycle, electron transport, and oxidative phosphorylation.
8.
Learn the mechanisms of regulation of carbohydrate metabolism by hormones and
metabolites.
VIII. Course outline:
SCHEDULE OF LECTURES
Week
1
2
3
4
5
6
7
8
Subject
Introduction to biochemistry; cells
Water and buffers
Structure of carbohydrates
Nucleotide structure
Amino acid structure
Amino acid properties and peptides
Protein function and classification
Protein purification and sequencing
Structure of fibrous proteins; collagen
Structure of globular proteins
Hemoglobin and immunoglobulins
Enzyme nomenclature
Vitamin coenzymes
Enzyme kinetics
Enzyme inhibition
Enzyme catalysis
Control of enzyme activity
Zymogens and blood clotting
Lipid structure and nomenclature
Structure of membranes
Membrane transport
9
10
11
12
13
14
15
16
IX.
Introduction to metabolic pathways
Bioenergetics and coupled reactions
ATP and phosphate transfer
The first stage of glycolysis
The second stage of glycolysis
Gluconeogenesis
The pentose phosphate pathway
Glycogen breakdown and synthesis
Regulation of carbohydrate metabolism
Hormones and second messengers
Oxidation of pyruvate
The citric acid cycle
Anabolic TCA cycle and glyoxylate cycle
Regulation of the citric acid cycle
Di- and oligosaccharide metabolism
Mitochondria and redox reactions
The electron-transport chain complexes
Oxidative phosphorylation
Mitochondrial shuttles
Final examination, comprehensive
Evaluation:
Three monthly examinations (60 % of course grade) and a comprehensive final
examination (40 % of course grade).
GRADING
Each monthly examination will be 100 points. Copies of old examinations are on reserve
on the first floor of Park Library. The comprehensive final examination is 200 points.
Copies of old final examinations are not on reserve. The grades are determined on a
percentage basis. Pluses and minuses are given to those on the upper and lower ends of
each grade range.
Grading Scale:
90-100%
80-89%
60-79%
50-59% 0-49%
A
B
C
E
Examinations must be taken during the scheduled time unless prior arrangements have
been made to take the examination early. No make-up examinations will be given. An
excused absence from one test will not effect your course grade. An unexcused absence
will result in a score of zero for that examination.
The requirements for undergraduates and graduates students are identical.
X.
Bibliography:
Textbooks:
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
Biochemistry by Stryer (4th edition), Freeman and Co., 1995
Principles of Biochemistry by Horton, et al, Neil Patterson Publishers, 1993
Biochemistry by Rawn, Neil Patterson Publishers, 1989
Biochemistry by Voet and Voet, (2nd edition), John Wiley & Sons, 1995
Biochemistry by Zubay (3rd edition), Wm. C. Brown Publishers, 1993
Harper's Biochemistry by Martin, et al (23rd edition), Lange Medical
Publications, 1991
Biochemistry by Garrett and Grisham, Saunders College Publishing, 1995
Biochemistry by Kuchel and Ralston (Shaum's Outline Series), McGraw-Hill
Book Company, 1988
Biochemistry by Devlin, (3rd edition), John Wiley & Sons, Inc., 1992
Biochemistry by Abeles, et al, Jones and Bartlett Publishers, l9g2
Modern Concepts in Biochemistry by Bohinski, (5th edition), Allyn and Bacon,
Inc., 1987
Biochemistry by Mathews and van Holde, Benjamin/Cummings Publishing
Company, 1990
References:
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
Annual Review of Biochemistry
CRC Handbook of Biochemistry
Comprehensive Biochemistry
Methods in Enzymology
Advances in Enzymology
Advances in Enzyme Regulation
The Enzymes
Vitamins and Hormones
Advances in Protein Chemistry
The Proteins
Advances in Lipid Research
Progress in Nucleic Acid Research and Molecular Biology
Periodicals:
1.
2.
3.
4.
5.
6.
Science
Chemical and Engineering News
Nature
Scientific American
Science News
Trends in Biological Sciences
Abstracts:
1.
2.
Chemical Abstracts
Biological Abstracts
Titles:
1.
2.
3.
4.
Current Contents
Index Medicus
Biological and Agricultural Index
Chemical Titles
Journals:
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Journal of Biological Chemistry
Proceedings of the National Academy of Science
Biochemistry
Biochemistry Journal
International Journal of Biochemistry
Archives of Biochemistry and Biophysics
Biochimica et Biophysica Acta
Analytical Biochemistry
Biochemistry and Biophysics Research Communication
Canadian Journal of Biochemistry and Cell Biology
Syllabus Prepared By:
Calvin Tormanen
Name
December 1, 1995
Date