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GenWay Biotech, Inc. 6777 Nancy Ridge Drive San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 [email protected] GABRA1 (gamma-aminobutyric acid (GABA) A receptor. alpha 1) Antibody, Rabbit Polyclonal Antibody Catalog Number: 18-003-42613 Related Product Names: - GABRA1 antibody; GABRA1; EJM; GABRA1 (gamma-aminobutyric acid (GABA) A receptor. alpha 1) - GABA(A) receptor subunit alpha-1; Gamma-aminobutyric acid (GABA) A receptor, alpha 1; Gammaaminobutyric acid receptor subunit alpha-1 - Gene Information Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact [email protected]. Gene Name: GABRA1 Gene Name Synonym: EJM Gi #: 38327554 NCBI Acc #: NP_000797.2 Swiss Prot Acc #: P14867 Length (aa): 456 Mol. Weight (Da): 51802 Chrom Location: N/A Antigen Specificity: Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human GABRA1. ELISA Titre: 1:62500 Category: Signaling Intermediates Note: Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Source/Host: Rabbit Purity/Purification: Rabbit Ig G is purified by peptide affinity chromatography method. Clonality: Polyclonal Crossreactivity: Human Format: Suggested dilution at 0.5 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50.000 - 100.000 as second antibody. Storage: Antibody is lyophilized from PBS buffer with 2% sucrose. Add 50 microl of distilled water. Final antibody concentration is 1 mg/ml. For longer periods of storage. store at -20C. Stability: Note: Avoid repeat freeze-thaw cycles. Shipping: Products may be shipped on ice pack or dry ice. APPLICATIONS for GABRA1 ANTIBODY: WB: Tested TESTING: (secondary reagents and protocols) WB: ( anti-GABRA1 ) GABRA1 antibody WB image GABRA1 ANTIBODY TARGET DESCRIPTION: Synonym Names for GABRA1 antibody: GABRA1; EJM; GABA(A) receptor subunit alpha-1; Gammaaminobutyric acid (GABA) A receptor, alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1 GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors. which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GA Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Subunit: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Subcellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Disease: Defects in GABRA1 are a cause of juvenile myoclonic epilepsy (JME) [MIM:606904]. JME is a common epileptic syndrome characterized by afebrile seizures, onset in adolescence (rather than in childhood) and myoclonic jerks. Disease: Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4) [MIM:611136]. ECA4 is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Absence seizures may either remit or persist into adulthood. Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family [view classification]. Summary: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. GABRA1 (gamma-aminobutyric acid (GABA) A receptor. alpha 1) reacts with human. OMIM: 137160; gene. [NCBI / EBI] 606904; phenotype. [NCBI / EBI] 611136; phenotype. [NCBI / EBI] BACKGROUND REFERENCES for GABRA1 ANTIBODY: Background references for antibody target are not specific to GenWay products Peran.M.. et al.. (2004) Neurosci. Lett. 364 (2). 67-70. Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order. Precautions: GABRA1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures. Important Notes: During shipment, small volumes of GABRA1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information. Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from SwissProt/TrEMBL and NCBI. To better serve our clients with everything we know about GABRA1 antibody, all related information, articles, resources about GABRA1 antibody are being stored on our online database. Let us know if you have questions regarding this product. Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: [email protected] www.genwaybio.com ©1998 - 2011 GenWay Biotech, Inc. - All Rights Reserved