The cell biology of major histocompatibility complex class
... Additionally the authors showed that calreticulin does not require either the lectin or ERp57-binding sites to associate with the PLC, and is recruited by means of a poorly defined polypeptide binding site. These findings are hard to reconcile with the ‘molecular glue’ hypothesis. However, a recent ...
... Additionally the authors showed that calreticulin does not require either the lectin or ERp57-binding sites to associate with the PLC, and is recruited by means of a poorly defined polypeptide binding site. These findings are hard to reconcile with the ‘molecular glue’ hypothesis. However, a recent ...
Fine Tuning of Sympathetic Transmitter Release via Ionotropic and
... nerve ending or from a different axon terminal. In the first situation, the receptor involved is a presynaptic autoreceptor, whereas in the second situation, the receptor is called a presynaptic heteroreceptor. Although the functions of presynaptic heteroreceptors were elucidated first, the detectio ...
... nerve ending or from a different axon terminal. In the first situation, the receptor involved is a presynaptic autoreceptor, whereas in the second situation, the receptor is called a presynaptic heteroreceptor. Although the functions of presynaptic heteroreceptors were elucidated first, the detectio ...
Melatonin Receptors Trigger cAMP Production and Inhibit Chloride
... was the release of chloride; and finally, the slope of the curve straight segment representing the velocity (V) of the chloride efflux. We used these parameters to evaluate the treatments versus the untreated cells that were taken as controls. These control cells showed the normal release of chlorid ...
... was the release of chloride; and finally, the slope of the curve straight segment representing the velocity (V) of the chloride efflux. We used these parameters to evaluate the treatments versus the untreated cells that were taken as controls. These control cells showed the normal release of chlorid ...
View PDF - CiteSeerX
... In an effort to identify new members of the nuclear receptor family, we performed a series of motif searches of public EST databases. These searches revealed a clone from a mouse liver library in the Washington University/HHMI EST database that had homology to the ligand-binding domains (LBDs) of a ...
... In an effort to identify new members of the nuclear receptor family, we performed a series of motif searches of public EST databases. These searches revealed a clone from a mouse liver library in the Washington University/HHMI EST database that had homology to the ligand-binding domains (LBDs) of a ...
Two different but converging messenger pathways to intracellular
... In general, the actions of most hormones and neurotransmitters, which release Ca2+ from internal stores, are blocked by heparin used as an IP3 receptor antagonist, but the possible involvement of cADPR and NAADP receptors has not been tested (Petersen and Cancela, 1999). It is therefore not known wh ...
... In general, the actions of most hormones and neurotransmitters, which release Ca2+ from internal stores, are blocked by heparin used as an IP3 receptor antagonist, but the possible involvement of cADPR and NAADP receptors has not been tested (Petersen and Cancela, 1999). It is therefore not known wh ...
Evolutionarily conserved recognition and innate immunity to fungal
... reducing target mRNA levels (Fig. S4, available at http://www .jem.org/cgi/content/full/jem.20082109/DC1) (29). Using a subset of the mouse lentiviral shRNA library targeting TLRs, scavenger receptors including CED-1 orthologues, c-type lectins, and other pattern recognition receptors (Fig. 2 a), we ...
... reducing target mRNA levels (Fig. S4, available at http://www .jem.org/cgi/content/full/jem.20082109/DC1) (29). Using a subset of the mouse lentiviral shRNA library targeting TLRs, scavenger receptors including CED-1 orthologues, c-type lectins, and other pattern recognition receptors (Fig. 2 a), we ...
Mechanisms of cross-talk between G-protein
... established that Ca2+ signalling by many Gα i -coupled receptors is via Gβγ -mediated activation of PLCβ [11–15]. The four identified PLCβ isoforms can be stimulated by Gβγ subunits [16,17], but there are marked differences in their sensitivities [16]. Thus the expression profile of PLCβ isoforms wi ...
... established that Ca2+ signalling by many Gα i -coupled receptors is via Gβγ -mediated activation of PLCβ [11–15]. The four identified PLCβ isoforms can be stimulated by Gβγ subunits [16,17], but there are marked differences in their sensitivities [16]. Thus the expression profile of PLCβ isoforms wi ...
Analgetika kuat, Schunack
... When the σ1 receptor was isolated and cloned, it was found to have no structural similarity to the opioid receptors. At this point, they were designated as a separate class of receptors. The functions of these receptors are poorly understood and any endogenous ligands have yet to be identified pro ...
... When the σ1 receptor was isolated and cloned, it was found to have no structural similarity to the opioid receptors. At this point, they were designated as a separate class of receptors. The functions of these receptors are poorly understood and any endogenous ligands have yet to be identified pro ...
Exocytosis acts as a modulator of the ILT4
... remains poorly defined. Here we show that primary human neutrophils expressed immunoglobulin-like transcript 4 (ILT4) inhibitory receptor and that this expression was induced during differentiation of the myelomonoblast PLB-985 cell line into “neutrophil-like” cells. Functional assays indicated that ...
... remains poorly defined. Here we show that primary human neutrophils expressed immunoglobulin-like transcript 4 (ILT4) inhibitory receptor and that this expression was induced during differentiation of the myelomonoblast PLB-985 cell line into “neutrophil-like” cells. Functional assays indicated that ...
Direct and Long-Range Action of a DPP Morphogen
... gives rise to a secreted protein that exerts a longrange organizing influence on both compartments. Using clones of cells that express DPP, or in which DPP receptor activity has been constitutively activated or abolished, we show that DPP acts directly and at long range on responding cells, rather t ...
... gives rise to a secreted protein that exerts a longrange organizing influence on both compartments. Using clones of cells that express DPP, or in which DPP receptor activity has been constitutively activated or abolished, we show that DPP acts directly and at long range on responding cells, rather t ...
NMDA Receptor Function and Physiological Modulation
... Figure 1 NMDA receptor component of excitatory postsynaptic potentials (EPSPs) and excitatory postsynaptic currents (EPSCs). (a) Unitary EPSP (‘EPSC’) recorded in a L2/3 cortical pyramidal neuron. The NMDA receptor-mediated component (subtraction) was obtained by subtracting the non-NMDA receptor-me ...
... Figure 1 NMDA receptor component of excitatory postsynaptic potentials (EPSPs) and excitatory postsynaptic currents (EPSCs). (a) Unitary EPSP (‘EPSC’) recorded in a L2/3 cortical pyramidal neuron. The NMDA receptor-mediated component (subtraction) was obtained by subtracting the non-NMDA receptor-me ...
Regulation of Natural Killer and CD4 T cell function by
... responses. It has become clear that NK cells can directly contribute to the innate immune defence against tumors, viruses and other microbial pathogens, but also regulate and promote adaptive immune responses. NK cells have a heterogeneous repertoire of surface activating receptors that allow them t ...
... responses. It has become clear that NK cells can directly contribute to the innate immune defence against tumors, viruses and other microbial pathogens, but also regulate and promote adaptive immune responses. NK cells have a heterogeneous repertoire of surface activating receptors that allow them t ...
TGF-beta SIGNAL TRANSDUCTION - University of Colorado-MCDB
... of structurally related polypeptide growth factors, each capable of regulating a fascinating array of cellular processes including cell proliferation, lineage determination, differentiation, motility, adhesion, and death. Expressed in complex temporal and tissue-specific patterns, TGF-β and related ...
... of structurally related polypeptide growth factors, each capable of regulating a fascinating array of cellular processes including cell proliferation, lineage determination, differentiation, motility, adhesion, and death. Expressed in complex temporal and tissue-specific patterns, TGF-β and related ...
G protein
... • These small molecules or ions that relay signals from one location to another in the cell are called second messengers • A cascade of changes may be induced in the receiving cell © 2012 Pearson Education, Inc. ...
... • These small molecules or ions that relay signals from one location to another in the cell are called second messengers • A cascade of changes may be induced in the receiving cell © 2012 Pearson Education, Inc. ...
phasic and tonic activation of gaba receptors - LIRA-Lab
... Box 1 | Multiple actions of GABAA receptors Responses generated by ionotropic receptors result from the dissipation of transmembrane ionic gradients, which are produced by ion pumps and carriers. GABAA (γ-aminobutyric acid type A) receptors are permeable to chloride and bicarbonate anions179,180. Th ...
... Box 1 | Multiple actions of GABAA receptors Responses generated by ionotropic receptors result from the dissipation of transmembrane ionic gradients, which are produced by ion pumps and carriers. GABAA (γ-aminobutyric acid type A) receptors are permeable to chloride and bicarbonate anions179,180. Th ...
Glutamate Controls the Induction of GABA
... was usually associated to a 5- to 12-mV membrane depolarization. Both GDPs as well as membrane depolarization disappeared when AMPA was applied in the presence of bicuculline (10 mM, data not shown), suggesting that both phenomena were due to the release of GABA after an incomplete block of AMPA rec ...
... was usually associated to a 5- to 12-mV membrane depolarization. Both GDPs as well as membrane depolarization disappeared when AMPA was applied in the presence of bicuculline (10 mM, data not shown), suggesting that both phenomena were due to the release of GABA after an incomplete block of AMPA rec ...
2. Fredriksson, R., et al., The G-protein
... throughout these studies. I also want to thank all the Dr. Naider laboratory members for the peptide syntheses that made this study possible. I really appreciate all the lab members in Dr. Becker’s laboratory: Special thanks to Dr. Melinda Hauser, Dr. Byung-Kwon Lee, and Dr. Tom Masi for their guida ...
... throughout these studies. I also want to thank all the Dr. Naider laboratory members for the peptide syntheses that made this study possible. I really appreciate all the lab members in Dr. Becker’s laboratory: Special thanks to Dr. Melinda Hauser, Dr. Byung-Kwon Lee, and Dr. Tom Masi for their guida ...
Specific vasopressin binding to rat adrenal glomerulosa cells
... agreement that enhanced production of Ins(1 ,4,5)P3 is an early post-receptor step in the mechanisms by which several hormones and neurotransmitters increase the concentration of cytosolic free Ca2+ in their target cells (for review, see Berridge & Irvine, 1984). It also provided a clue for characte ...
... agreement that enhanced production of Ins(1 ,4,5)P3 is an early post-receptor step in the mechanisms by which several hormones and neurotransmitters increase the concentration of cytosolic free Ca2+ in their target cells (for review, see Berridge & Irvine, 1984). It also provided a clue for characte ...
Eph signalling and morphogenesis - Development
... except for the location of the eye stalk. EphA4 expression persists in the ventral and dorsal diencephalic regions. In embryos injected with the dominant-negative RNA, the forebrain regions fated to become ventral diencephalon become retina instead and large expanded eyes are formed. Again, the exac ...
... except for the location of the eye stalk. EphA4 expression persists in the ventral and dorsal diencephalic regions. In embryos injected with the dominant-negative RNA, the forebrain regions fated to become ventral diencephalon become retina instead and large expanded eyes are formed. Again, the exac ...
PDF - Herbert Publications
... similar to those of the host’s own antigens, then how does the immune system differentiate between self and nonself? A possible answer is that nonself recognition occurs at the level of whole cells rather than surface immune receptors, which, however, are also involved in the process. ...
... similar to those of the host’s own antigens, then how does the immune system differentiate between self and nonself? A possible answer is that nonself recognition occurs at the level of whole cells rather than surface immune receptors, which, however, are also involved in the process. ...
Mechanism Of Hormonal Action:1
... substance, secreted by ductless glands (endocrine glands). It passes through blood stream to reach the tissues on which it acts. These tissues are called “target tissues”. Dr. Hani Alrefai - 2014 ...
... substance, secreted by ductless glands (endocrine glands). It passes through blood stream to reach the tissues on which it acts. These tissues are called “target tissues”. Dr. Hani Alrefai - 2014 ...
PowerPoint 프레젠테이션
... the central and peripheral nervous system.1 • Adenosine is an endogenous purine nucleoside that, following its release from cells or after being formed extracellularly, diffuses to the cell membrane of surrounding cells where it binds specific cell-surface structures that recognize it, termed adenos ...
... the central and peripheral nervous system.1 • Adenosine is an endogenous purine nucleoside that, following its release from cells or after being formed extracellularly, diffuses to the cell membrane of surrounding cells where it binds specific cell-surface structures that recognize it, termed adenos ...
Serotonin 5-HT Receptors: Chemical Neuronatomy in the
... these species using [3H]mesulergine. The distribution of 5-HT2C receptor binding sites in the human brain is somewhat different from that found in the rat brain (Pazos and Palacios 1985; Hoyer et al. 1986). In the rat hippocampus, 5-HT2C receptor binding sites are located in the stratum lacunosum m ...
... these species using [3H]mesulergine. The distribution of 5-HT2C receptor binding sites in the human brain is somewhat different from that found in the rat brain (Pazos and Palacios 1985; Hoyer et al. 1986). In the rat hippocampus, 5-HT2C receptor binding sites are located in the stratum lacunosum m ...
Hormones & Chemical Messengers
... • Diffuses into cytosol and or into the nucleus • Acts as a transcription factors in the nucleus to alter gene activity by – Repressing or activating rates of transcription – Lag period due to the processes that have to occur ...
... • Diffuses into cytosol and or into the nucleus • Acts as a transcription factors in the nucleus to alter gene activity by – Repressing or activating rates of transcription – Lag period due to the processes that have to occur ...