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Chapter 10 Lymphatic and Immune Systems Chapter Objectives Upon completion of the chapter the participant will be able to: 1. 2. 3. 4. 5. 6. Describe the major functions of the lymphatic system. Label on a diagram the organs which make up the lymphatic system Describe the major functions of the lymphatic system. Describe the major functions of the immune system. Analyze, define and pronounce terms related to the lymphatic and immune systems. Successfully complete the review exercises at the end of the chapter. The Lymphatic System The major structures of the lymphatic system are the lymph vessels, lymph nodes, lymph fluid, tonsils and adenoids, spleen, thymus and lymphocytes. This system has its own vessels and fluids but does not have its own cells. Blood cells that are specialized fill this role. The functions of the lymphatic system in the body include: ¾ return excess lymph (interstitial fluid) to the blood stream ¾ carry nutrients, hormones and oxygen to body tissue ¾ absorb fats and fat soluble vitamins from the digestive system and transports them to the cells ¾ functions as part of the immune system The vascular component of the lymphatic system consists of three types of vessels: ¾ lymphatic capillaries which are the smallest vessels. These vessels have thin walls and carry the lymph from the tissue spaces to the larger lymph vessels. These larger vessels are called ..... ¾ lymphatics, which drain into the larger ........ ¾ right and left lymph ducts Lymph Nodes The lymph nodes are located in the lymph vessels and are small bean-shaped structures. These nodes provide storage for the cells of the immune system (B cells and T cells). The primary function of the nodes is to filter the lymph fluid and rmove any harmful substances such as bacteria, viruses and malignant cells. After these agents are filtered the immune system destroys them. Lymph Fluid The fluid of the lymphatic system is called lymph. It is also known as intercellular or interstitial fluid. This is a colorless clear fluid that leaves the capillaries and moves into Revised 2005-09-13 -111- the tissue spaces. The function of the fluid is to bring nutrients and hormones to the cells. It will also remove waste products from the cells. Lymph Glands A number of glands in the body are made up of lymphatic tissue and play a role in the immune system functioning. These are: ¾ Tonsils (tonsil/o) and Adenoids (adenoid/o) o located in the neck o filters for bacteria o three pairs are located in the throat. These are: palatine (palat/o)(located in the oropharynx & are visible through the mouth) nasopharyngeal (also called adenoids) lingual (lingu/o)(located at the base of the tongue) ¾ Spleen (splen/o) o large organ located in the left side of the abdomen o storehouse for red blood cells and releases them when required o contains a great many phagocytes that breakdown red blood cells and other cellular debris. o in the adult if the bone marrow is damaged the spleen can function to produce red blood cells. ¾ Thymus gland (thym/o) o located near the heart in the chest cavity o it is both a lymphatic and an endocrine gland o stimulates the bone marrow to produce T-cells which then mature in the thymus gland. Lymph Nodes Lymph Duct Revised 2005-09-13 -112- Lymph duct Lymph node Capillary bed Immune System The immune system (immun/o) is there to protect the entire body from a variety of harmful substances such as bacteria, viruses, toxins, malignant cells, etc. Unlike other body systems the immune system is not contained within a single set of organs or vessels. The immune system depends on structures from the lymphatic, cardiovascular and integumentary systems. The immune system works primarily through an antigen/antibody reaction. An antigen is any substance that the body views as being foreign to its normal functioning: eg virus, bacteria. An antigen that gets into the body causes the formation of antibodies. Antibodies are disease-fighting proteins that are developed by the body to respond to the antigen that has invaded it. The antibody results in the antigen no longer being harmful to the body. The body has specialized cells that are responsible for the immune reaction to antigens. Some of these are: ¾ Lymphocytes o A class of white blood cells that specialize in the attack of microorganisms. o Formed in the lymphatic tissue ¾ T cells o o o o Revised 2005-09-13 A small type of lymphocyte produced in the bone marrow Matures in the thymus gland Primary function is to coordinate immune defenses and kill organisms Are also involved in the body’s rejection of transplanted tissue. -113- Your health status is an important factor in the ability of your immune system to respond to an antigen invading your body. The healthier you are the more likely that your immune system can respond effectively. As we age the immune system tends to respond less quickly and effectively to a challenge. If you are resistant to a particular type of infection you are said to have immunity. At birth you have some inborn immunity to some antigens and then during our life we “acquire” immunity to other conditions e.g. antibodies develop after measles so you don’t get them again. Word Parts for the Lymphatic and Immune Systems Roots ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ aden/o denoid/o aut/o blast/o carcin/o immun/o lingu/o lymphaden/o lymphangi/o lymph/o nas/o onc/o palat/o phag/o pharyng/o splen/o therap/o thym/o tonsil/o gland adenoid self immature cancer immunity, safe tongue lymph gland (node) lymph vessels lymph nose tumor palate or roof of mouth eating or swallowing pharynx, throat spleen therapy thymus gland tonsils Suffixes ¾ -immune ¾ -lytic ¾ -oma immunity, safe destroy tumor Prefixes ¾ ¾ ¾ ¾ ¾ antimacrometamicr/o peri- Revised 2005-09-13 against large beyond, change small surround -114- Term Analysis and Definition Word Part Term Term Analysis Definition aut/o autoimmune disease aut = self immun = immune Disease in which the body makes antibiotics that attack its own tissue immun/o immunology immun = immune, safe -logy= study of Study of the immune system immunity -ity = condition, state State of being resistant to disease or having immunity lymphaden/o Lymphadenopathy lymph = lymph aden - gland -pathy = disease Disease of the lymph gland lymphangi/o lymphangitis lymph = lymph angi = vessel -itis = inflammation Inflammation of the lymph vessels lymph/o lymphedema lymph = lymph -edema = accumulation of fluid Accumulation of fluid due to an obstruction in the lymph system. lymphoma -oma = tumor Tumor of the lymph structures splenectomy splen = spleen -ectomy = surgical removal Surgical removal of the spleen splenorrhagia -rrhagia = bursting forth Hemorrhage from the spleen thym/o thymectomy thym = thymus gland -ectomy = surgical removal Surgical removal of the thymus gland. -phoresis Electrophoresis electr = electric -phoresis = carry, transmission Lab test in which substances are separated by transmission of an electric current splen/o Vocabulary Words: Autoimmune disease a condition in which the body’s immune system becomes defective and produces antibodies against itself ex: hemolytic anemia, rheumatoid arthritis Lymph a clear, colourless, alkaline fluid found in the lymphatic Revised 2005-09-13 -115- vessels Lymphedema an abnormal accumulation of lymph in the interstitial spaces Lymphoma a lymphoid neoplasm, usually malignant Opportunistic infection A protozoal, fungal, viral or bacterial infection that occurs when one’s immune system is compromised. Abbreviations: AIDS acquired immune deficiency syndrome HIV human immunodeficiency virus Revised 2005-09-13 -116-