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Cystic Fibrosis IVFAustralia’s Network of Care Clinic Consultation & Monitoring IVFAustralia’s guide to your screening Consulting Rooms Bondi Jn Burwood Castle Hill 16th Floor Westfield Tower 2, 500 Oxford St Suite 18 Level 7, 74-76 Burwood Suite 4, 15-17 Terminus St 8305 9800 8346 6840 9894 4419 Dee Why Gosford Greenwich Level 3, 834 Pittwater Road Level 2 Suite 24, 207 North Albany St Level 2, 176 Pacific Highway 9950 6000 4349 2000 9425 1600 Haymarket Kogarah Liverpool Level 5 Sussex Centre 401 Sussex St Level 3 St George Private Hospital South St Ground Floor 16-18 Bigge St 9281 3822 8567 6955 8844 1575 Maroubra Miranda Newcastle Level 1, 225 Maroubra Rd Suite 4, 20-24 Gibbs St The Heights Private Medical Centre 2 Lookout Rd New Lambton Heights 8372 3200 8567 6980 4957 8515 St Leonards Sydney CBD Wahroonga 16 Marshall Ave Level 1, 33 York St Suite 103 Tulloch Building Sydney Adventist Hospital 185 Fox Valley Road Wahroonga 9439 3158 8346 6800 9425 1780 Westmead Wollongong Level 2, 20-22 Mons Rd Suite 3, 336 Crown St 8844 1550 4271 3900 HUNTER IVF NEW LAMBTON HEIGHTS GOSFORD WAHROONGA CASTLE HILL DEE WHY CHATSWOOD WESTMEAD BURWOOD GREENWICH ST LEONARDS HAYMARKET . SYDNEY BONDI JN RANDWICK LIVERPOOL MAROUBRA ivf.com.au | 1800 111 IVF MIRANDA A member of HEALTH WOLLONGONG COMM-PI-122 | 8MAY2015 KOGARAH Is Cystic Fibrosis common? Cystic Fibrosis is the most common life threatening genetic condition affecting Australian newborns. One in every 2,500 babies, male or female, born in Australia will have CF. It is estimated one in 25 Caucasian Australians are carriers of CF although they have no symptoms of the disease. Faulty CF genes are found in people of other ethnic backgrounds too, however it is not as common, for example the risk for an Asian person to be a carrier of CF is 1 in 90. Could your child be at risk of having Cystic Fibrosis? · · · Cystic Fibrosis (CF) is the most common life threatening condition affecting Australian newborns 1 in 25 Caucasian Australians are carriers of a CF gene fault Screening for CF gene faults is available at IVFAustralia’s inhouse genetics laboratory What is Cystic Fibrosis? Cystic Fibrosis (CF) is an inherited genetic disorder that affects the respiratory and digestive system, sweat glands and male fertility from infancy through to adulthood. The gene involved in CF regulates the production of a protein in cells that control the movement of salt in and out of cells. CF causes the formation of thick mucus that traps bacteria, resulting in infections that damage both the lungs and the gut. Babies and children with CF need daily physiotherapy for their lungs and frequent courses of antibiotics to treat the bacterial infections. Despite modern treatments there is currently no cure and CF sufferers have a reduced life expectancy. For a child to have Cystic Fibrosis both parents must be carriers of the gene fault responsible for CF. When two CF carriers have a child there is a 1 in 4 chance their child will be affected by CF, a 1 in 2 chance their child will be a carrier of a CF gene fault though not affected by CF, and a 1 in 4 chance the child will not inherit any CF gene fault, and therefore will not be affected by CF or at risk of passing a CF gene fault to future generations. Every cell in a person’s body has two copies of Chromosome 7, one of which they inherit from each parent. If one of those copies has the gene fault responsible for CF then the person is a ‘carrier’ for the condition. If a child inherits two copies of Chromosome 7 that both have a gene fault known to cause CF then the child will have inherited the CF disorder. Male CF carriers frequently have a gene fault that is associated with infertility. You may wish to consider having at least one partner screened for CF prior to commencing any fertility treatment given the CF carrier rate is higher in infertile males and many CF carriers are completely healthy adults with no family history of the disorder. CF Screening at IVFAustralia IVFAustralia’s inhouse CF screening program provides a fast result following a simple blood test of one partner. If the test is negative, the risk of your child being affected by CF is extremely low and there is no need for any further concern. If, however, your test identifies you as a CF carrier, a specialist will recommend that your partner should be tested. Both parents need to be carriers of the CF mutation in order for the child to be affected. In the event both partners are carriers a full explanation of the risk of having a child affected by CF will be provided. Test Costs Screening for CF mutations is not covered by Medicare and a fee of $255 is charged (this expense can go towards out of pocket tax deduction). Is Cystic Fibrosis common? Cystic Fibrosis is the most common life threatening genetic condition affecting Australian newborns. One in every 2,500 babies, male or female, born in Australia will have CF. It is estimated one in 25 Caucasian Australians are carriers of CF although they have no symptoms of the disease. Faulty CF genes are found in people of other ethnic backgrounds too, however it is not as common, for example the risk for an Asian person to be a carrier of CF is 1 in 90. Could your child be at risk of having Cystic Fibrosis? · · · Cystic Fibrosis (CF) is the most common life threatening condition affecting Australian newborns 1 in 25 Caucasian Australians are carriers of a CF gene fault Screening for CF gene faults is available at IVFAustralia’s inhouse genetics laboratory What is Cystic Fibrosis? Cystic Fibrosis (CF) is an inherited genetic disorder that affects the respiratory and digestive system, sweat glands and male fertility from infancy through to adulthood. The gene involved in CF regulates the production of a protein in cells that control the movement of salt in and out of cells. CF causes the formation of thick mucus that traps bacteria, resulting in infections that damage both the lungs and the gut. Babies and children with CF need daily physiotherapy for their lungs and frequent courses of antibiotics to treat the bacterial infections. Despite modern treatments there is currently no cure and CF sufferers have a reduced life expectancy. For a child to have Cystic Fibrosis both parents must be carriers of the gene fault responsible for CF. When two CF carriers have a child there is a 1 in 4 chance their child will be affected by CF, a 1 in 2 chance their child will be a carrier of a CF gene fault though not affected by CF, and a 1 in 4 chance the child will not inherit any CF gene fault, and therefore will not be affected by CF or at risk of passing a CF gene fault to future generations. Every cell in a person’s body has two copies of Chromosome 7, one of which they inherit from each parent. If one of those copies has the gene fault responsible for CF then the person is a ‘carrier’ for the condition. If a child inherits two copies of Chromosome 7 that both have a gene fault known to cause CF then the child will have inherited the CF disorder. Male CF carriers frequently have a gene fault that is associated with infertility. You may wish to consider having at least one partner screened for CF prior to commencing any fertility treatment given the CF carrier rate is higher in infertile males and many CF carriers are completely healthy adults with no family history of the disorder. CF Screening at IVFAustralia IVFAustralia’s inhouse CF screening program provides a fast result following a simple blood test of one partner. If the test is negative, the risk of your child being affected by CF is extremely low and there is no need for any further concern. If, however, your test identifies you as a CF carrier, a specialist will recommend that your partner should be tested. Both parents need to be carriers of the CF mutation in order for the child to be affected. In the event both partners are carriers a full explanation of the risk of having a child affected by CF will be provided. Test Costs Screening for CF mutations is not covered by Medicare and a fee of $255 is charged (this expense can go towards out of pocket tax deduction). Cystic Fibrosis IVFAustralia’s Network of Care Clinic Consultation & Monitoring IVFAustralia’s guide to your screening Consulting Rooms Bondi Jn Burwood Castle Hill 16th Floor Westfield Tower 2, 500 Oxford St Suite 18 Level 7, 74-76 Burwood Suite 4, 15-17 Terminus St 8305 9800 8346 6840 9894 4419 Dee Why Gosford Greenwich Level 3, 834 Pittwater Road Level 2 Suite 24, 207 North Albany St Level 2, 176 Pacific Highway 9950 6000 4349 2000 9425 1600 Haymarket Kogarah Liverpool Level 5 Sussex Centre 401 Sussex St Level 3 St George Private Hospital South St Ground Floor 16-18 Bigge St 9281 3822 8567 6955 8844 1575 Maroubra Miranda Newcastle Level 1, 225 Maroubra Rd Suite 4, 20-24 Gibbs St The Heights Private Medical Centre 2 Lookout Rd New Lambton Heights 8372 3200 8567 6980 4957 8515 St Leonards Sydney CBD Wahroonga 16 Marshall Ave Level 1, 33 York St Suite 103 Tulloch Building Sydney Adventist Hospital 185 Fox Valley Road Wahroonga 9439 3158 8346 6800 9425 1780 Westmead Wollongong Level 2, 20-22 Mons Rd Suite 3, 336 Crown St 8844 1550 4271 3900 HUNTER IVF NEW LAMBTON HEIGHTS GOSFORD WAHROONGA CASTLE HILL DEE WHY CHATSWOOD WESTMEAD BURWOOD GREENWICH ST LEONARDS HAYMARKET . SYDNEY BONDI JN RANDWICK LIVERPOOL MAROUBRA ivf.com.au | 1800 111 IVF MIRANDA A member of HEALTH WOLLONGONG COMM-PI-122 | 8MAY2015 KOGARAH