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The Mysteries of Life WITH SHIN HEE, YEON JAE, AND CHARLIE Table of Contents.... Title Glossary Essential questions for DNA Essential questions for Mitosis, Meiosis, and Cell Cycle Quiz Bibliography/Sources of Pictures/Interactive SItes p.1 p. 2 p. 4 p. 7 p. 11 p. 12 Glossary: You should understand these 15 important words before you read the textbook. Asexual reproduc.on DNA In asexual reproduc/on, one parent clones itself to create a gene/cally iden/cal organism. This is done by mitosis because they produce two new iden/cal cells. Cell Cycle DNA (deoxyribonucleic acid) is the gene/c material that carries informa/on about an organism and is passed down from and for genera/ons. The instruc/ons inside a nucleus are in the form of a DNA. DNA Replica.on The cell cycle is a cycle where the cells go through steps‐ that includes DNA replica/on, and cell division. This is the process where the DNA replicates an iden/cal copy of itself. This process happens before mitosis when the cell divides. Gene Cell division Genes are the “instruc/on manual” in your bodies. Genes are one segment of DNA. They tell the cell what and how a protein that helps perform special func/ons was made. Cell division means the process of the cell dividing into more cells, producing more offsprings. Growth + Repair Chromosomes Chromosomes are double‐ rod shaped structures that contains /ghtly packed DNAs. Proteins are circled around the DNA. Every cell has 46 chromosomes or 23 pairs of them. Some animals can “regenerate” parts of their bodies that have gone missing or have been damaged. For example, the starfish is an animal that can regenerate a part of its body. If it loses an arm, aRer a while, that arm will grow back just like a new one. Glossary (Continued): Meiosis RNA Meiosis is a process which produces sex cells‐ sperm and egg. In this process, one cell creates four non‐ iden/cal, but similar cells. This is done in sexual reproduc/on. Mitosis Sexual Reproduc.on Mitosis is when the cells divides to create 2 new iden/cal cells. This happens through what is called a DNA replica/on. Mitosis can not produce varia/ons. Nucleus Trait Nucleic acids contain informa/on of the body’s growth and the role of the cell. It is made from carbon, oxygen, hydrogen, nitrogen, and phosphorus, DNA and RNA are nucleic acids. Nucleic Acid A nucleic acid is a very long organic molecule made of carbon, oxygen, hydrogen, nitrogen, and phosphorus. It contains the instruc/ons that cells need in their life/me. It is found in all living cells and viruses. Two types of nucleic acid is DNA and RNA. A RNA is a nucleic acid which looks like a half of a DNA. DNA uses RNA to transfer informa/on and instruc/ons to the other organelles. The instruc/ons are mostly about making proteins which will be sent to another organelle in the cell called ribosomes. Sexual reproduc/on is a process that includes sex. A sperm cell with 23 chromosomes(half of the chromosomes), and a egg cell with the other 23 chromosomes produces a new unique organism that contains genes passed from genera/ons before that organism. Trait is an unique visible feature of an organism. We inherit traits from our parents, and pass them onto our future genera/ons. Genes play an important role in determining traits. DNA Figure 1: The DNA looks like twisted ladder. The nitrogen bases are between the backbone. What is the fact and fiction of the statement “DNA is like a tightly wound rubber band doing the same job as a hard drive on your computer.” - Our DNA is shaped like a twisted ladder like a tightly wound rubber band. However, when you stretch the DNA into one long line, it is meters and meters long. If you stretch a rubber band, it is also much longer than its normal size. -The DNA does the similar work to a hard drive on a computer. The nucleus in which the DNA is in contains the instructions for growth and development, and the roles of the cells in our body, and determines your traits. However, the hard drive cannot replicate itself, but the DNA can, through a process called cell cycle. Figure 2 A picture of a DNA and hard drive. & What does it look like (its structure) and what is it made from? DNA looks like a twisted ladder, the scientific word for it is double helix. The side of the ladder, the backbone of the DNA is made out of deoxyribose(sugar) and phosphate. Each rung is made out of nitrogen bases (cytosine, guanine, adenine, thymine). The bases are linked together with hydrogen bonds. However, thymine only pairs up with adenine, and guanine always pairs up with cytosine; and these are base pairs. Each of the little sections among the DNA strand is a gene. If the DNA strand is made out of letters (ATGCGTA), genes are made of words (ATGCGTA,ATGCTAT). The way information from the DNA is delivered to the rest of the cell is by RNA. hyodrogen bond Figure 3 The structure of a DNA. What is DNA and where is it found? DNA (deoxyribonucleic acid) is a type of nucleic acid. It is a genetic material that has the instructions like the growth and development of the cell passed down from and for generations. Everyone’s DNA is unique, except for identical twins. It is found in the the cell’s brain or the nucleus of a cell. Inside the cell, there are 46 double-rob shaped structures called chromosomes. The DNA are packed together tightly inside the chromosomes. Figure 4 This is a picture of a chromosome. Chromosomes are contained in the nucleus of the cell. DNA are packed in the chromosomes. How and why does DNA copy itself? Cells multiply in a process called cell division. When one cell divides into two new cells, the DNA in the old cell copies itself through a process called DNA replication. First, an enzyme breaks apart the hydrogen bond that links that nitrogen bases together. This causes the two DNA strands to separate. These separated DNA stands float around the cytoplasm and find new nitrogen bases. Thymine only pairs up with adenine. Guanine only pairs up with cytosine. Then sugar and phosphate generally makes the back bone for the DNA, and two new and identical DNA strands are made! Figure 5: This is a picture that shows DNA replication. When you grow, you need more cells in your body. You also need more cells in order to get new and healthy cells. When the cells multiply, they need to exact same DNA so it copies itself to make the number of DNA the same in each cell. This process is done by mitosis/meiosis. Figure 6: A gene What are genes and where are genes found? Genes -Genes are made from segments of DNA. It tells the cells to make protein to function and to operate all parts of the body. Genes also determine your traits, a visible feature of a person. Traits Types of Traits: -Physical traits-the physical makeup (ex. Hair, eye color/height) -Behavioral traits- the characteristics of how a person acts. (personality) -Predisposition to a medical condition- A higher risk of getting a disease is also a trait passed down from generations. Traits are inherited from your parents. The egg cell(23 chromosomes)+sperm cells(23 chromosomes)=a baby. - You can find genes everywhere in your body because without the genes, your body wouldn’t function. It is found in our chromosomes. Figure 7: This is a picture of a gene. Genes make proteins and they are found in chromosomes. Cell Cycle, Mitosis, Meiosis Compare and contrast a photocopier and a muscle cell? The photocopier and the muscle cell is similar, because they both make copies. A muscle cell copies itself by going through mitosis. There, in the cell’s nucleus, the chromosomes will be doubled and split into two new identical cells. A photocopier copies by copying a document and creating a second version that is exactly alike. However, the photocopier and the muscle cells have their differences too. When the photocopier copies a document, the new document will have been created, but the original copy will still exist; whereas, in mitosis, the original will no longer exist, since it would have been split into by making two new cells. Also, with photocopiers, you can make as many copies as you wish, but a muscle cell will only split to make two at once. VS. Figure 8 A photocopier VS. A muscle cell Compare and contrast chromosomes and playing cards? Chromosomes and playing cards have similarities. A chromosome is where the DNA is packed- and there are 23 pairs of chromosomes in each cell. Each chromosome has two chromatids, with one centromere connecting them. For example, the chromosomes and the playing cards both come in sets- and everything in the deck has a double. VS. Also, in order to ‘form’ a deck, there needs to be all the cards. To make a cell, there needs to be all the chromosomes as well. The difference, however, is that chromosomes are exactly alike, but in a Figure 9 deck of cards, there is only one of each type of Chromosomes VS. Playing Cards card. What is the relationship between the cell cycle, mitosis, and meiosis? There are many relationships between the cell cycle, mitosis, and meiosis. For example, the mitosis is the part of the cell cycle. Cell cycle is the process that every cell needs to go through when it does the three parts- growth, repair, and multiplication or division. Mitosis is a part of the last stage in the cell cycle where the cells are copying themselves. The meiosis is related to mitosis, because they are both forms of cell division; except mitosis is only used to divide body cells, and meiosis is only used to divide sex cells-egg and sperm. Figure 10: This is a picture of cell division. Mitosis and meiosis is both forms of cell division. Figure 11: This is a picture of a cell cycle. What is each process used for? The cell cycle is the whole process (growth&repair, division, and DNA replication) of the cell. Mitosis is the when the nucleus divides into two identical nuclei. Meiosis is when the chromosomes divides into half and creates sex cells. What is similar about these processes? The processes- cell cycle, mitosis and meiosis all duplicate chromosomes, and replicate them. What is different about these processes? Mitosis is for cells, and meiosis is for DNA, and cell cycle has much more steps- all of the processes divides something (either chromosomes, cells, or nucleus) and create something else. They number of the cells produced are also different. Video: Mitosis This is a video about Mitosis. Enlarge and double click image to start to movie! Video: Meiosis This is a video about Meiosis. Enlarge and double click image to start the movie. Figure 12: This is a picture of meiosis and mitosis. What are the advantages and disadvantages of both sexual and asexual reproduction? Asexual Reproduction With the asexual reproduction, lots and lots of babies will be made. With asexual reproduction, a partner is not needed; so the population can never die out because of lack of reproduction. This process is much faster, and easier than a sexual reproduction- since there are less steps. It also doesn’t allow any variation-there can only be replications of the original organism. This can be a good trait, because if a “bad” trait gets passed on, an organism will not be able to live for long. The disadvantage of this process is also the fact that genetic variation is not allowed. For example, if they want to go to a new environment very different from the environment they were previously living in, it will be very difficult to adapt. But, if the one organism is sick and not immune to something, the babies will also be sick like the mother. Sexual Reproduction The advantage for sexual reproduction, on the other hand, is that genes can change for generations and generations. Therefore, with the variations, the organisms will be able to adapt to a new environment easily, because it can create enhanced offsprings. The disadvantages of this process, is that for most cases, you need to opposite sex to create an offspring. If there are no more organisms of the opposite gender in the area, then the population would die out. Also, you don’t make as many offsprings as offsprings created in an asexual reproduction. Animals that asexually reproduce: Figure 13, 14 These asexually reproduced animals don’t have a gender. They also can’t have variations. Bacteria Protist Animals that sexually reproduce: Figure 15, 16 None of the sexually produced animals has the same gene except for identical twins. These animals can produce variations. Us, humans Dog 15 Question Multiple Choice Quiz: There are 15 multiple choice questions. The answers are at the end of the page. 1. What is the difference between mitosis and meiosis? a. Mitosis produced two identical cells, and meiosis produces two different cells. b. Mitosis produces sex cells, and meiosis produces two identical cells. c. Mitosis produces two identical cells, and meiosis produces sex cells. d. Mitosis and meiosis have no difference between each other. 2. What is the correct base pair? a. cytosine, thymine b. cytosine, guanine c. adenine, guanine d. Cytosine, guanine, adenine, thymine can pair up with any nitrogen base. 3. Which is NOT a process in Mitosis? a. Structures called centrioles move to the opposite ends of the cell and fibers begin to stretch across the cell. b. The chromosomes line up along the center of the cell and the centromere attach to the two spindle fibers. c. Sugar helps the cell cut in half and two new cells are created. d. The separated chromosomes makes its own membrane in order to make a new nucleus. The membrane splits into two and two new cells are formed. 4. How can you make asexual reproduction occur in a plant? a. By splitting a plant through the middle. b. Give the plant a hormone that can help them asexually reproduce. c. By planting another plant next to a plant. d. By cutting a branch from it and replanting it. 5. How much percent of the mom and dad’s genes does the child get in a process called asexual reproduction? a. Mom 100%, Dad 0% b. Mom 0%, Mom 100% c. Mom 50%, Dad 50% d. Organisms that asexually reproduce don’t have males and females. d. The nucleus breaks down food and energy. 10. What are genes? a. Female sex cells b. The outer back bones of DNA molecules. c. The part of a chromosome that determines a particular characteristic. d. Male sex cell 11. What is the function of the DNA? a. To produce more chromosomes. b. It determines your personality. c. It protects you against infection. d. It’s a blueprint for your body. 12. Which one of these are NOT coded in your DNA? a. Your eye color. b. The language you speak. c. Your bone structure. d. The color of your hair. 13. Who are the only people with the same exact genes? a. Fraternal twins only b. Identical twins only c. Any kind of twin d. No one 14. In cell division, which cell part divides first? a. The nucleus b. The cell wall c. The cell membrane d. None of the above 15. What is a chromosome? a. A small piece of a cell membrane b. Two chromatids held together by a centromere c. The protein center of a cell d. None of the above 6. Which is not a type of trait? a. Physical traits (ex. Hair, eye color/height) b. Behavioral traits (ex. the way you act, personality) c. Educational traits (ex. determines how smart you are) d. Predisposition to a medical condition (ex. diseases) 7. Which statement is correct? a. DNA>Genes>2 Chromatids>Chromosome b. Genes>DNA>Chromosomes>2 Chromatids c. 2 Chromatids>DNA>Genes>Chromosomes d. Chromosomes>2 Chromatids> Genes>DNA 8. DNA is similar to which choice? a. The bricks that make up a building. b. The cements that cover up the building’s walls. c. The blueprint(design plan) of a building. d. The people that work in the building. 9. What is a nucleus? a. The nucleus is the brain of the cell, and controls what the cell does. b. The nucleus forms the outer layer of the cell. c. The nucleus flows around the cell carrying structures called organelles. Answers: 1. c, 2. b, 3. c, 4. d, 5. d, 6. c, 7. a, 8. c, 9. a, 10. c, 11. d, 12. b, 13. b, 14. a, 15.b Glossary pictures (If you want to look at the glossary photos more closely, you can click on these links and it will show you the original copy of the photo.) • http://dj003.k12.sd.us/images/amoeba-fission-big.jpg (asexual reproduction) • http://imagesearch.naver.com/search.naver?where=idetail&rev=5&query=%BC%BC %C6%F7%20%C1%D6%B1%E2&from=image&ac=-1&sort=0&res_fr=0&res_to=0&merge=0&spq=0&start=8&a=pho_l&f=t ab&r=8&u=http%3A%2F%2Fblog.naver.com%2Fgenetic2002%3FRedirect%3DLog%26logNo %3D20015938470&thumbnail=http%3A%2F%2Fthumbview02.search.naver.com%2Fthumbnails%3Fq%3Dhttp%3A%2F %2Fblogfiles.naver.net%2Fdata12%2F2005%2F8%2F17%2F219%2F%25BC%25BC %25C6%25F7%25C1%25D6%25B1%25E2genetic2002.jpg&signature=109670157967&gdid=90000003_0000000000000004A90AFBA6 (cell cycle) • images-mesoblast_cell_division_still.jpg (cell division) • http://www.daviddarling.info/images/cell_division.jpg (mitosis&meiosis) • http://staff.jccc.net/PDECELL/celldivision/chromosome1.gif (chromosomes) • http://www.brown.edu/Courses/BI0032/gentherp/dnarep.gif (DNA replication) • http://puesoccurrences.files.wordpress.com/2009/07/dna_500.jpg (DNA) • http://www.makingthemodernworld.org.uk/learning_modules/biology/01.TU.03/illustrations/01.IL.09.gif (RNA) • http://www.tapirback.com/tapirgal/gifts/friends/aquatic/starfish-orange-plastic-f1024a.jpg (growth + repair: starfish) • http://www3.itu.edu.tr/~sariel/figures/Gene.png (gene) • http://www.scdaamobile.org/images/traits02.jpg (traits) • http://library.thinkquest.org/06aug/01942/plcells/thinkquest/nucleus.jpg (nucleus) • http://www.dkimages.com/discover/previews/769/85011519.JPG (nucleic acid) • http://www.dkimages.com/discover/previews/766/152402.JPG (sexual reproduction) Interactive Sites and Bibliography www.brainpop.com *Type in DNA, Asexual Reproduction, Mitosis, Genes, etc. in the search box, watch the video. http://www.sci.sdsu.edu/multimedia/mitosis/ *It is a good website for understanding how mitosis works by looking at a animation. http://biologyinmotion.com/cell_division/ *If you want to try out how mitosis and meiosis works, check out this site as well. http://www.tvdsb.on.ca/westmin/science/sbi3a1/Genetics/Replicat.htm *If you want to know more about DNA replication, this is the site just for you! There is a good animation about DNA replication. http://www.cellsalive.com/mitosis.htm http://www.cellsalive.com/meiosis.htm *This is a very good site to help you understand mitosis and meiosis. Play the animation for each one. There is also a explanation underneath the animation. Sources for pictures: Figure 1: http://ghr.nlm.nih.gov/handbook/illustrations/dnastructure.jpg Figure 2: http://computer-reviews.net/files/western%20digital%20caviar%20se %2016%20400GB%20hard%20drive.jpg, http://puesoccurrences.files.wordpress.com/ 2009/07/dna_500.jpg FIgure 3: http://www.scq.ubc.ca/wp-content/dna.gif Figure 4: http://www.ams.org/featurecolumn/images/chromosome.gif Figure 5: http://dna.microbiologyguide.com/s/10002/pics/dnareplication.png Figure 6: http://icare4autism.files.wordpress.com/2009/04/gene_chromosome.jpg Figure 7: http://publications.nigms.nih.gov/thenewgenetics/images/ch1_dnagenes.jpg Figure 8: http://www.nissansilvia.com/forums/uploads/monthly_09_2009/ post-12890-12531018157635.jpg, http://www.mda.org/publications/images/Limb-GirdleDiagram-paths.jpg FIgure 9: http://www.magicbob2000.com/resources/hocus%20cards_edited-3.jpg, http:// biology.unm.edu/ccouncil/Biology_124/Images/chromosome.gif FIgure 10: http://www.mesoblast.com/images/images-mesoblast_cell_division_still.jpg Figure 11: http://www.physiomics-plc.com/images/Cell%20Cycle11-12-05.jpg Figure 12: http://www.daviddarling.info/images/cell_division.jpg Figure 13: www.biojobblog.com/bacteria.jpg Figure 14: http://rst.gsfc.nasa.gov/Sect20/paramecium_stained.jpg FIgure 15: Photo Booth FIgure 16: http://static.squidoo.com/resize/ squidoo_images/-1/\draft_lens1441580module8530159photo_Dog_Medicine_Side_Effects 5.jpg1204589384