Download Cell Bio Syllabus

Syllabus for Cell Biology
Cell Biology BIOL 350
Professor: Dr. Doyle Holbird
Email: [email protected]
Text: Essential Cell Biology published by Garland Science 3rd Edition
Spring Semester 2014
Office Meyer Hall 209
Overview:
This course is intended to introduce the student to the basic components, structures, and inner workings of cells
that allow them to form the basic unit of life. Emphasis will be placed upon the ultrastructure, organization, and
function of cellular organelles, as well as the regulation of cellular activities by mechanisms such as negative
feedback and signal transduction. A basic chemistry course is required before beginning this course and organic
chemistry is recommended. General Biology and College Algebra are also required before beginning this course.
Objectives of BIOL 350
In parenthesis are the Biology learning outcomes to which each objective pertains. These outcomes may be found
on the last page of the syllabus.
Upon successful completion of this course students will be able to:
1. Identify the major organelles of the cell in eukaryotes and prokaryotes and enumerate their
functions. Describe differences between eukaryotes and prokaryotes including DNA structure.
(1, 2)
2. Enumerate the major steps involved as well as the enzymes that carry out the major steps of
the cell cycle, transcription, translation and replication. (1,2)
3. Describe the processes involved before and after translation that regulate protein production and
modify and target proteins for their use in the cell. (1, 2)
4. Describe the proteins and processes involved in cell movement. (1, 2)
5. Enumerate the major chemical components of the cell and describe their function. (1, 2)
6. Describe the major mechanisms of cell-cell and intracellular communication. (1, 2,)
7. Perform basic lab procedures in cell culture, genetics and enzyme kinetics. (1, 4)
8. Determine from lab exercises as well as graphs, the type of kinetics involved in enzyme
activities. (1, 4)
9. Explain how mutations in DNA can affect morphology and function in cells and organisms, and
how this relates to the evolution of species as well as its limitations in evolution. (1, 2)
Expectations of the student:
This course is designed for students majoring in a science field. Therefore, it is anticipated that those enrolled in
this course are committed to putting forth more than average effort, and devoting more than average time to
mastering the topics that will be covered. It is expected that students will prepare themselves for each lecture
period by spending an average of 1.5 to 2 hours of reading and study after class hours for each hour spent in class.
Reading assignments are given with the expectation that students will read them prior to coming to class on that
day. Study guides or worksheets will be given to help reinforce the portions of the readings that are considered
more important. Although worksheets will not be graded, students who do not work through them will not
perform well on exams. If you come across terminology with which you are unfamiliar you should look it up in
the textbook or on the internet, so that you fully understand the concepts that are presented. Do not guess at what
a sentence means look it up. The textbook has a website that can be very helpful. If you find it useful use it. If
you look terms up on the internet make sure that the site you use is reputable and correct in its explanations. It is
expected that students will remain awake and alert during class. Do not put your head down on your desk to rest
during class. If you do I will assume that you are in need of rest and will send you out to get some sleep.
Beginning the second week each class period will consist of 3 parts. 1. Lecture
2. Discussion
The quiz will cover the reading assignment or the study questions.
Note: if students are keeping up in their reading assignments the quizzes may be ommitted.
3. Quiz
Cell Phones: Ringing cell phones always bring class lectures to a screeching halt. Avoid bringing cell phones to
class. At the minimum, silence your phone before class begins. Receiving cell phone calls or text messages during
the class period is prohibited. Opening a cell phone during a quiz or exam will result in an automatic failure of
that exam or quz. Laptops are not allowed in class. It has been shown that grades are lower when students take
notes on laptops.
Attendance policy:
Attendance at all lectures and lab is required. Due to the nature of some labs makeup laboratory opportunities
may not be available. However, some lab materials may be available after certain lab exercises are over so that
you will be able to make up some lab exercises. Be on time for both lectures and labs. There are no make up
quizzes. Exams that are missed due to an excused absence may be made up by prior arrangement with the
professor.
Helpful Hints:
1. Stay caught up...study each week for the next quiz/exam. The day after one exam is finished
you should be studying with an eye toward the next exam.
2. Begin an intense preparation for each exam at least 7-10 days before the test date.
3. Study with someone and verbally quiz one another. Quiz yourself to be sure that you knowthe answer.
4. When studying, put less emphasis on memorizing facts and terms, and more emphasis on
integrating the concepts into a “working understanding of the material”. Work problems at the end of your
chapters in the book. Use the website of the textbook publisher.
5. Some of the material in this class lends itself to rote memorization. Some material does not
lend itself so easily to memorization. Therefore, it is necessary for students to learn the concepts that each
section is trying to teach. Understand sequences that are covered. Know why one step in a
multistep process follows the previous step. This will help you do well on the exams, and
also help you to understand cellular processes. Work the problems at the end of each chapter for practice.
Work all problems on the study guide.
6. As stated before the textbook publisher has a helpful website. Make use of it.
http://www.garlandscience.com/garlandscience_student/student_home.jsf?landing=student&conversationId=30
7478
Laboratory: The lab is scheduled to meet once a week for 3 hours. There may be periods in which the lab will
meet for less than the entire 3 hours, as well as other times in which the student will have to come in on other days
during the week in order to finish lab projects.
Grading:
This course will be graded on the basis of a total point system. All points for lecture and lab that are earned by a
student will be added together for the final grade. Every student has the opportunity to earn the same number of
points. Sections of the book entitled “How we know” will be considered as quiz material, but will not be covered
on exams. Each exam will be considered to be cumulative, in that material from past exams may be present on the
new exam.
Grading Scale:
93 - 100 % = A
90 - 92% = A87 - 89
83 - 86
80 - 82
= B+
=B
= B-
77 – 79
73 – 76
70 – 72
= C+
=C
= C-
67 – 69
63 – 66
60 – 62
= D+
=D
= D-
Opportunities to earn points:
Lecture Quizzes 20 quizzes
Lecture Exams 4 Exams
Lab Practical
10 Lab Quizzes/Assignments
Total Points For the Course
1-2 Pts each
100 Pts Each
50 Points
10 Pts Each
580 Points
Course Outline/Readings:
Dates
January: 12
14th
16th
General Topic
Microscopy / Organelles
Model Organisms
Cell Chemistry
21st
23rd
Energy and Catalyis
Catalysis, Enzyme Kinetics cont’d
3
3
81-93
93-112
26th
28th
30th
Proteins Structure and Function
Proteins cont’d
Proteins cont’d
chap
4
4
119- 131
132-141
141-168 &
571-575
Feb 2nd
4th
6th
Cytoskeleton Intermediate filaments
Cytoskeleton Microtubules
Cytoskeleton Actin/Muscle
17
17
17
572-579
579-590
591-605
9th
11th
13th
EXAM 1
Transcription / Splicing of Genes
Splicing cont’d /Translation of proteins
7
7
230-246
246-258
Chapter
1
1
2
Readings (Page numbers in text)
6-26
27-36
be familiar with→65-78
6
Feb. 16th
18th
20th
President’s Day
Gene Expression Cont’d Begin chap. 8
Transcriptional Switches
7-8
8
258-272
272-281
23rd
25th
27th
Gene Expression Controls
Genetic Variation / evolutionary concepts
Molecular Biology Techniques
8
9
10
278-293
293-322
323-333
March 2nd
4th
6th
Sequencing and Hybridization
PCR, Genetic Engineering
EXAM #2
10
10
334-346
347-361
16th
18th
20th
Membrane Structure
Membrane Proteins
Diffusion, Mem.proteins
11
11
12
365-374
374-387
389-403
23rd
25th
27th
Membrane potential
Ion channels and nerve cells
Intracellular Compartments and Transport
12
12
15
403-410
411-423
497-510
30th
April 1st
Intracellular compartments sorting
Endocytic Pathways
15
15
510-522
522-528
April 8th
April 10th
EASTER BREAK
Catchup Day
EXAM #3
13th
15h
17th
Signal Transduction
G Protein Linked Receptors etc
Enzyme Linked Receptors
16
16
16
533-541
541-555
555-569
20th
22st
24th
The Cell Cycle
DNA Checkpoints Mitosis
Cell number and size control
18
18
18
609-620
620-630
631-641
April 27th
29th
May 1st
Growth Factors cont’d
Extracellular Matrix
Cell Sheets
18
20
20
641-648
689-700
700-711
4th
6
8th
Stem Cells
Cancer
Catchup
20
20
711-717
717-729
Exam #4 & Final
Note: If there is time we will review the chapters that deal with cell energy extraction.
*The course outline, as well as the total points may change as the course proceeds.
Biology Program Learning Outcomes:
1. Demonstrate proficiency in the language and terminology of biology and effectively communicate biological knowledge,
and ideas.
2. Exhibit knowledge of the basic structures, fundamental processes and relationships of life at the molecular, cellular, and
organismal levels.
3. Find and evaluate various types of scientific information such asquantitative data, qualitative data, and that found within
research journals, mass media, and the worldwide web.
4. Demonstrate proficiency of basic lab techniques and use of scientific instrumentation.