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Syllabus for Cell Biology Cell Biology BIOL 350 Professor: Dr. Doyle Holbird Email: [email protected] Text: Essential Cell Biology published by Garland Science 3rd Edition Spring Semester 2014 Office Meyer Hall 209 Overview: This course is intended to introduce the student to the basic components, structures, and inner workings of cells that allow them to form the basic unit of life. Emphasis will be placed upon the ultrastructure, organization, and function of cellular organelles, as well as the regulation of cellular activities by mechanisms such as negative feedback and signal transduction. A basic chemistry course is required before beginning this course and organic chemistry is recommended. General Biology and College Algebra are also required before beginning this course. Objectives of BIOL 350 In parenthesis are the Biology learning outcomes to which each objective pertains. These outcomes may be found on the last page of the syllabus. Upon successful completion of this course students will be able to: 1. Identify the major organelles of the cell in eukaryotes and prokaryotes and enumerate their functions. Describe differences between eukaryotes and prokaryotes including DNA structure. (1, 2) 2. Enumerate the major steps involved as well as the enzymes that carry out the major steps of the cell cycle, transcription, translation and replication. (1,2) 3. Describe the processes involved before and after translation that regulate protein production and modify and target proteins for their use in the cell. (1, 2) 4. Describe the proteins and processes involved in cell movement. (1, 2) 5. Enumerate the major chemical components of the cell and describe their function. (1, 2) 6. Describe the major mechanisms of cell-cell and intracellular communication. (1, 2,) 7. Perform basic lab procedures in cell culture, genetics and enzyme kinetics. (1, 4) 8. Determine from lab exercises as well as graphs, the type of kinetics involved in enzyme activities. (1, 4) 9. Explain how mutations in DNA can affect morphology and function in cells and organisms, and how this relates to the evolution of species as well as its limitations in evolution. (1, 2) Expectations of the student: This course is designed for students majoring in a science field. Therefore, it is anticipated that those enrolled in this course are committed to putting forth more than average effort, and devoting more than average time to mastering the topics that will be covered. It is expected that students will prepare themselves for each lecture period by spending an average of 1.5 to 2 hours of reading and study after class hours for each hour spent in class. Reading assignments are given with the expectation that students will read them prior to coming to class on that day. Study guides or worksheets will be given to help reinforce the portions of the readings that are considered more important. Although worksheets will not be graded, students who do not work through them will not perform well on exams. If you come across terminology with which you are unfamiliar you should look it up in the textbook or on the internet, so that you fully understand the concepts that are presented. Do not guess at what a sentence means look it up. The textbook has a website that can be very helpful. If you find it useful use it. If you look terms up on the internet make sure that the site you use is reputable and correct in its explanations. It is expected that students will remain awake and alert during class. Do not put your head down on your desk to rest during class. If you do I will assume that you are in need of rest and will send you out to get some sleep. Beginning the second week each class period will consist of 3 parts. 1. Lecture 2. Discussion The quiz will cover the reading assignment or the study questions. Note: if students are keeping up in their reading assignments the quizzes may be ommitted. 3. Quiz Cell Phones: Ringing cell phones always bring class lectures to a screeching halt. Avoid bringing cell phones to class. At the minimum, silence your phone before class begins. Receiving cell phone calls or text messages during the class period is prohibited. Opening a cell phone during a quiz or exam will result in an automatic failure of that exam or quz. Laptops are not allowed in class. It has been shown that grades are lower when students take notes on laptops. Attendance policy: Attendance at all lectures and lab is required. Due to the nature of some labs makeup laboratory opportunities may not be available. However, some lab materials may be available after certain lab exercises are over so that you will be able to make up some lab exercises. Be on time for both lectures and labs. There are no make up quizzes. Exams that are missed due to an excused absence may be made up by prior arrangement with the professor. Helpful Hints: 1. Stay caught up...study each week for the next quiz/exam. The day after one exam is finished you should be studying with an eye toward the next exam. 2. Begin an intense preparation for each exam at least 7-10 days before the test date. 3. Study with someone and verbally quiz one another. Quiz yourself to be sure that you knowthe answer. 4. When studying, put less emphasis on memorizing facts and terms, and more emphasis on integrating the concepts into a “working understanding of the material”. Work problems at the end of your chapters in the book. Use the website of the textbook publisher. 5. Some of the material in this class lends itself to rote memorization. Some material does not lend itself so easily to memorization. Therefore, it is necessary for students to learn the concepts that each section is trying to teach. Understand sequences that are covered. Know why one step in a multistep process follows the previous step. This will help you do well on the exams, and also help you to understand cellular processes. Work the problems at the end of each chapter for practice. Work all problems on the study guide. 6. As stated before the textbook publisher has a helpful website. Make use of it. http://www.garlandscience.com/garlandscience_student/student_home.jsf?landing=student&conversationId=30 7478 Laboratory: The lab is scheduled to meet once a week for 3 hours. There may be periods in which the lab will meet for less than the entire 3 hours, as well as other times in which the student will have to come in on other days during the week in order to finish lab projects. Grading: This course will be graded on the basis of a total point system. All points for lecture and lab that are earned by a student will be added together for the final grade. Every student has the opportunity to earn the same number of points. Sections of the book entitled “How we know” will be considered as quiz material, but will not be covered on exams. Each exam will be considered to be cumulative, in that material from past exams may be present on the new exam. Grading Scale: 93 - 100 % = A 90 - 92% = A87 - 89 83 - 86 80 - 82 = B+ =B = B- 77 – 79 73 – 76 70 – 72 = C+ =C = C- 67 – 69 63 – 66 60 – 62 = D+ =D = D- Opportunities to earn points: Lecture Quizzes 20 quizzes Lecture Exams 4 Exams Lab Practical 10 Lab Quizzes/Assignments Total Points For the Course 1-2 Pts each 100 Pts Each 50 Points 10 Pts Each 580 Points Course Outline/Readings: Dates January: 12 14th 16th General Topic Microscopy / Organelles Model Organisms Cell Chemistry 21st 23rd Energy and Catalyis Catalysis, Enzyme Kinetics cont’d 3 3 81-93 93-112 26th 28th 30th Proteins Structure and Function Proteins cont’d Proteins cont’d chap 4 4 119- 131 132-141 141-168 & 571-575 Feb 2nd 4th 6th Cytoskeleton Intermediate filaments Cytoskeleton Microtubules Cytoskeleton Actin/Muscle 17 17 17 572-579 579-590 591-605 9th 11th 13th EXAM 1 Transcription / Splicing of Genes Splicing cont’d /Translation of proteins 7 7 230-246 246-258 Chapter 1 1 2 Readings (Page numbers in text) 6-26 27-36 be familiar with→65-78 6 Feb. 16th 18th 20th President’s Day Gene Expression Cont’d Begin chap. 8 Transcriptional Switches 7-8 8 258-272 272-281 23rd 25th 27th Gene Expression Controls Genetic Variation / evolutionary concepts Molecular Biology Techniques 8 9 10 278-293 293-322 323-333 March 2nd 4th 6th Sequencing and Hybridization PCR, Genetic Engineering EXAM #2 10 10 334-346 347-361 16th 18th 20th Membrane Structure Membrane Proteins Diffusion, Mem.proteins 11 11 12 365-374 374-387 389-403 23rd 25th 27th Membrane potential Ion channels and nerve cells Intracellular Compartments and Transport 12 12 15 403-410 411-423 497-510 30th April 1st Intracellular compartments sorting Endocytic Pathways 15 15 510-522 522-528 April 8th April 10th EASTER BREAK Catchup Day EXAM #3 13th 15h 17th Signal Transduction G Protein Linked Receptors etc Enzyme Linked Receptors 16 16 16 533-541 541-555 555-569 20th 22st 24th The Cell Cycle DNA Checkpoints Mitosis Cell number and size control 18 18 18 609-620 620-630 631-641 April 27th 29th May 1st Growth Factors cont’d Extracellular Matrix Cell Sheets 18 20 20 641-648 689-700 700-711 4th 6 8th Stem Cells Cancer Catchup 20 20 711-717 717-729 Exam #4 & Final Note: If there is time we will review the chapters that deal with cell energy extraction. *The course outline, as well as the total points may change as the course proceeds. Biology Program Learning Outcomes: 1. Demonstrate proficiency in the language and terminology of biology and effectively communicate biological knowledge, and ideas. 2. Exhibit knowledge of the basic structures, fundamental processes and relationships of life at the molecular, cellular, and organismal levels. 3. Find and evaluate various types of scientific information such asquantitative data, qualitative data, and that found within research journals, mass media, and the worldwide web. 4. Demonstrate proficiency of basic lab techniques and use of scientific instrumentation.