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Unit 6 Genetics Module B: Continuity and Unity of Life Objectives: 1. Genes and inheritance 2. Mutations and chromosome abnormalities 3. Genetic engineering Lesson 1: Genes and Inheritance • Gene – region of DNA that codes for a specific protein. • Allele – different versions of a gene • Polygenic – trait that is determined by more than one gene. Dominant and Recessive Alleles • Phenotype: physical appearance of a trait. (physical appearance) • Genotype: the alleles of a trait. (genetic makeup) • Dominant allele – when present it is expressed. • Recessive allele – masked if a dominant allele is present. • Dominant and Recessive Alleles • Pea plants inherit two alleles for traits. – Tall is dominant “T” – Short is recessive “t” Pea plant’s possible genotypes for height: Genotype Phenotype TT (homozygous dominant) tall Tt (heterozygous dominant) tall tt (homozygous recessive) short Homozygous: when there are two of the same alleles for a trait. Ex. TT, tt Heterozygous: when there are two different alleles for a trait. Ex. Tt Identify the following: Tt Answer: genotype, heterozygous Tall Answer: phenotype Homozygous recessive Answer: genotype • Punnett Squares - Shows the possible allele combinations and phenotypes of the offspring of a given set of parents. A = dominant yellow a = recessive green Probability: Yellow = Green = Ratio = • Pedigree chart – can be used to trace inheritance of a trait through multiple generations of related individuals. • Males = squares • Females = circles • Shaded shapes indicate that person has the trait. AA or aa • Half-shaded shapes indicate that person is a carrier, doesn’t express trait. Aa • Horizontal bar connecting two individuals represents a set of parents. • Vertical bar represents offspring. Incomplete Dominance, CoDominance, and Multiple Alleles - Incomplete dominance – heterozygous individual has a phenotype that differs from those with either homozygous genotype. - Blending of two alleles. Co-dominance – heterozygotes express both the dominant and recessive phenotypes, rather than a blend. -expresses both traits. Ex. Roan cattle • Multiple-allele – some genes have more than two possible alleles. • Ex. ABO blood type Alleles: IA, IB, i (i is O type) • Blood type is determined by the presence of a carbohydrate group attached to a protein on the surface of red blood cells. Sex-linked traits • Traits found on the genes on a sex chromosome. • Sex chromosomes are XX female or XY male. • X chromosome is larger and contains more genes than the Y. • Ex. Hemophilia – blood-clotting disorder is determined by a single gene on the X chromosome. • The allele is recessive, males get it more because they only have one X chromosome. • A man with hemophilia and a woman who has no history of the disease in her family plan to have a child. The parents’ genotypes are XhY and XHXH • Homework: pg. 138 – 140 • Questions 1-6 • Due Wednesday