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Transcript
BLOS HazCom - Part P. Bigelow Laboratory for Ocean Sciences Biosafety Policy & Institutional Biosafety Committee The primary responsibilities of the Institutional Biosafety Committee (IBC) are three-fold: 1) to provide general oversight of all research involving BioSafety Level 2 and higher organisms (see table below), 2) to oversee the evaluation and approval process for proposals using recombinant DNA technologies on all organisms, and 3) to ensure that researchers using such methods are following through with compliance with the Bigelow Laboratory Policy on Genetic Manipulation and the NIH guidelines on this topic, in particular those related to the health and safety of the environment and surrounding community. Biosafety Levels Examples of cells Exempt BSL-1 Wild-type cells from non-human/non-primate species that have NOT been exposed to any microbial agent and have not been genetically modified OR cells determined by the IBC to be NIH exempt. BSL-1 Cells from nonhuman/primate species that have NOT been exposed to any microbial agent, but have been genetically modified using non-viral methods OR cells determined by the IBC to be approved as non-exempt BSL-1 BSL-2 Cells from humans or primates OR Cells that have been geneticallly modified using viral methods OR Cells exposed to microbial agents AND have been approved by the IBC for BSL-2 containment and sorting. BSL-2+ (enhanced) Cells exposed to microbial agents with moderate increased personal hazard OR Cells that have been genetically modified using viral methods with known oncogenic inserts AND have been approved by the IBC for BSL-2+ containment and sorting. Bigelow Laboratory for Ocean Sciences takes the issue of working with genes and their host organisms, with or without their modification, very seriously. The IBC documents outline the procedures to be followed when working with BSL 2 or higher organisms and genes, including the process of deciding whether to engage in a project that involves genetic modification or genetic engineering. These documents can be found on BLOS Storage\Resources\Safety\IBC or by contacting the chair of the IBC (see below). For clarity, when working with genes it is necessary to distinguish between genetic modification and genetic engineering. Genetically Modified Organisms (GMOs) are organisms in which the DNA from another genus (or higher taxonomic level) has been inserted into an organism in a laboratory. Genetically Engineered (GE) organisms are strains which have been genetically-altered in the lab but do not contain artificially-inserted DNA from another organism. GE organisms are created instead through exposure to a DNA mutagen (e.g., ultraviolet light, chemical agents), by directed gene ‘knock-outs’, or by targeted gene editing. In practice, most of the existing federal guidelines for biosafety have been written with GMOs in mind, but there is still sometimes ambiguity around what exactly is meant by a GMO. For the purposes of this document, Bigelow Laboratory will adhere to the definitions above. Bigelow Laboratory’s policy is that all proposed research that use BSL 2 or higher organisms, with or without the use of recombinant and/or synthetic DNA methods, must BLOS HazCom Part P Created 21 Oct 2014 Reviewed: 6/30/2017 first be reported to the IBC committee via a registration document (BLOS HazCom Appendix 18A and B, or Storage\Resources\Safety\IBC, or from the IBC chair). Current IBC members: Dr. Mike Lomas, SRS, chair Dr. Peter Countway, SRS Dr. David Emerson, SRS Dr. Jose Antonio Fernandez Robledo, SRS Wendy Bellows, Safety Officer Tim Pinkham, Lab Manager Dr. Sarah Foulger, Pastor, BBH Congregational Church Lauren Graham, BRHS science teacher BLOS HazCom Part P Created 21 Oct 2014 Reviewed: 6/30/2017