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1. 2009 Quiz 1--Question 1 Which of the following statements about amino acids is false? 1. 2. 3. 4. 5. Score: Student Value Response Asparagine 100% is an acidic amino acid. Lysine and histidine are both basic amino acids, and lysine is more strongly basic than histidine. Leucine, valine, and alanine are all hydrophobic amino acids. Peptide bonds involving proline place local limitations on the ability of a protein to fold. Tryptophan has a large, bulky side chain. Correct Answer Feedback 0.2/0.2 2. 2009 Quiz 1--Question 2 Inosine is a purine that is identical to adenine, except that the amine group attached to carbon 6 is replaced with a keto group. If inosine were incorporated into double stranded DNA, how many hydrogen bonds could it form with cytosine and how many with thymine? How many repulsive ionic interactions would occur between inosine and cytosine, and how many would occur between inosine and thymine? 1. 2. 3. 4. 5. Student Value Correct Answer Response hydrogen They messed up bonds: 1 this question so with they put all thymine, 3 answers as right. with cytosine repulsive interactions: 1 with thymine, 0 with cytosine hydrogen bonds: 2 with thymine, 3 with cytosine repulsive interactions: 0 with thymine, 1 with cytosine hydrogen 0% bonds: 1 with thymine, 2 with cytosine repulsive interactions: 1 with thymine, 1 with cytosine hydrogen bonds: 0 with thymine, 3 with cytosine repulsive interactions: 0 with thymine, 0 with cytosine hydrogen bonds: 3 Feedback with thymine, 3 with cytosine repulsive interactions: 0 with thymine, 0 with cytosine Score: 0/0.2 3. 2009 Quiz 1--Question 4 Which of the following factors is responsible for a water molecule being a dipole? 1. 2. 3. 4. 5. Score: Student Value Correct Answer Response the similarity in electronegativity of hydrogen and oxygen the tetrahedral structure of liquid water the magnitude 100% of the H–O–H bond angle the ability of water to hydrogen bond to various chemical structures the difference in bond strength between hydrogen bonds and covalent bonds 0.2/0.2 4. 2009 Quiz 1--Question 5 Feedback All of the following are correct about a primary transcript in eukaryotes except that it (Note: the 'functional RNA' is the mRNA or the noncoding RNA that results after processing of the primary transcript.) 1. 2. 3. 4. 5. Score: Student Value Response is usually longer than the functional RNA. may contain nucleotide sequences that are not present in the functional RNA. contains no modified bases. could contain information for more than one RNA molecule. contains a 100% TATA box. Correct Answer Feedback 0.2/0.2 5. Question 8 What happens to a supercoiled, circular DNA molecule if it becomes nicked? Student Value Response 1. Torsional stress increases and a linear molecule forms. Correct Answer Feedback 2. Torsional stress decreases and a linear molecule forms. Torsional 100% 3. stress decreases and a relaxed circle forms. 4. Torsional stress increases and a relaxed circle forms. 5. Transcription is initiated. Score: 0.2/0.2 6. 1. Alternative splicing Assuming that all three exons can be alternatively spliced, how many distinct mRNAs can be generated from the gene below? Student Value Response 1. 3 2. 6 7 100% 3. 4. 24 5. 72 Score: Correct Answer Feedback 0.2/0.2 7. Question 1-4 Which of these fragments of DNA has the highest melting temperature? Both complementary strands for each fragment are shown (names 1st and 2nd) Student Response Value Correct Answer Feedback 1. 1st TATATAAATTTATTTAA 2nd _____ATATATTTAAATAAATT 2. 1st ACAAATGTCTGCGATT 2nd _____TGTTTACAGACGCTAA 3. 1st AGACAAGTCC 2nd _____TCTGTTCAGG 1st AGACAAGTCCGCGATT 100% 4. 2nd _____TCTGTTCAGGCGCTAA Score: 0.2/0.2 8. Question 1-5 Which statement(s) is/are true? 1. 2. 3. 4. 5. Student Value Response Ions can cross lipid bilayers only if they are smaller than a water molecule Biomembranes are composed of hydrophobic molecules Phospholipids 100% can diffuse rapidly within the plane of the membrane The amino acid leucine in its monomeric form can cross freely lipid bilayers Phospholipids interact with other phospholipids Correct Answer Feedback through ionic interactions Score: 0.2/0.2 9. Question 1-9 Which statement(s) is/are true? 1. 2. 3. 4. Score: Student Value Response Hydrogen 50% bonds can be disrupted by heat Hydrogen 50% bonds can be formed between methanol and water Hydrogen bonds can be formed between a CH3group and a NH2group. Hydrogen bonds are weaker than van der Waals interactions Correct Answer Feedback 0.2/0.2 10. RNA processing Referring to the diagram below, which of the following are true of the mature RNA transcript encoded by this gene? More than one answer may be correct, so you may select multiple responses. You will lose partial credit for each incorrect response selected, and gain partial credit for each correct response selected. 1. 2. 3. 4. 5. Student Value Response All nucleotides in the primary transcript are found in the mature transcript. All nucleotides in the mature transcript are found in the primary transcript. Transcription 100% begins at the +1 position. Translation begins at the +1 position. None of the above are true. Correct Answer Feedback