Mary Ann Osley*, Alastair Fleming, and Cheng
... linkage between ubiquitin and the target protein or between individual ubiquitin molecules in the case of polyubiquitylation. The large family of Ubps suggests that, like E3s, Ubps have significant specificity with respect their targets. Moreover, multiple Ubps may act on a single target. For exampl ...
... linkage between ubiquitin and the target protein or between individual ubiquitin molecules in the case of polyubiquitylation. The large family of Ubps suggests that, like E3s, Ubps have significant specificity with respect their targets. Moreover, multiple Ubps may act on a single target. For exampl ...
Aberrant Epigenetic Regulation Could Explain the Relationship of
... crease the risk of schizophrenia through multiple pathways including direct effects on the expression of genes involved in neuropsychiatric pathology or indirectly through imprinting errors in genes related to the normal functioning of the placenta. X-chromosome Inactivation X-chromosome inactivatio ...
... crease the risk of schizophrenia through multiple pathways including direct effects on the expression of genes involved in neuropsychiatric pathology or indirectly through imprinting errors in genes related to the normal functioning of the placenta. X-chromosome Inactivation X-chromosome inactivatio ...
Genome Evolution and Developmental Constraint in Caenorhabditis
... because of developmental constraint. To test this hypothesis, a genomewide examination of molecular evolution through ontogeny was carried out using comparative genomic data in Caenorhabditis elegans and Caenorhabditis briggsae. We found that the mean rate of amino acid replacement is not significan ...
... because of developmental constraint. To test this hypothesis, a genomewide examination of molecular evolution through ontogeny was carried out using comparative genomic data in Caenorhabditis elegans and Caenorhabditis briggsae. We found that the mean rate of amino acid replacement is not significan ...
Trends in Gene - silencing Research
... gene silencing only lasts for about 5 days. This was considered a drawback of siRNAs when using them as drugs, but research conducted in 2003 provides a solution to this[20]. HIV viruses invade the macrophages by binding to CCR5 receptors present at the macrophage surface, so the inhibition of their ...
... gene silencing only lasts for about 5 days. This was considered a drawback of siRNAs when using them as drugs, but research conducted in 2003 provides a solution to this[20]. HIV viruses invade the macrophages by binding to CCR5 receptors present at the macrophage surface, so the inhibition of their ...
Physiological and Molecular Plant Pathology (2001) 59, 33-43
... The deduced amino-acid sequences were round highly similar to other PR-10 with, as expected, highest degrees of sequence identity to Mal d 1 isoforms. In particular, AP2 was round nearly identical to AP15 (accession No: L42952), a Mal d 1 isoform from M. domestica cv. Golden Delicious induced during ...
... The deduced amino-acid sequences were round highly similar to other PR-10 with, as expected, highest degrees of sequence identity to Mal d 1 isoforms. In particular, AP2 was round nearly identical to AP15 (accession No: L42952), a Mal d 1 isoform from M. domestica cv. Golden Delicious induced during ...
AmpliScribe™ T7 High Yield Transcription Kit
... Extract with TE-saturated phenol/chloroform, followed by chloroform. Ethanolprecipitate the RNA or precipitate the RNA using ammonium acetate as described in Purification of the RNA. RNA may be cleaned up also using Zymo RNAClean and Concentrator or Qiagen RNEasy spin columns, or by using Ammonium a ...
... Extract with TE-saturated phenol/chloroform, followed by chloroform. Ethanolprecipitate the RNA or precipitate the RNA using ammonium acetate as described in Purification of the RNA. RNA may be cleaned up also using Zymo RNAClean and Concentrator or Qiagen RNEasy spin columns, or by using Ammonium a ...
Gene Codon Composition Determines Differentiation
... further that KCs substantially change their tRNA profiles upon differentiation. Aminoacyl-tRNAs from differentiated KCs but not undifferentiated KCs enhanced the translation of authentic L1 mRNA, suggesting that differentiation-associated change to tRNA profiles enhances L1 expression in differentia ...
... further that KCs substantially change their tRNA profiles upon differentiation. Aminoacyl-tRNAs from differentiated KCs but not undifferentiated KCs enhanced the translation of authentic L1 mRNA, suggesting that differentiation-associated change to tRNA profiles enhances L1 expression in differentia ...
Ribosome stalls at trp codons, allowing 2+3 pairing Transcription
... Enzymes acting in pathway to produce tryptophan. Gene order correlates with order of reactions in pathway. Premature termination of transcription when trp levels are high ...
... Enzymes acting in pathway to produce tryptophan. Gene order correlates with order of reactions in pathway. Premature termination of transcription when trp levels are high ...
One of the crucial proteins to influence type 2 diabetes
... will help determine whether the IVS5-13insC shows a consistent association with type 2 diabetes. However, the direct mechanism by which this variant affects mRNA expression or amino acid sequence remains unclear. As we have shown above, HMGA1 mainly act as an architectural transcription factor invol ...
... will help determine whether the IVS5-13insC shows a consistent association with type 2 diabetes. However, the direct mechanism by which this variant affects mRNA expression or amino acid sequence remains unclear. As we have shown above, HMGA1 mainly act as an architectural transcription factor invol ...
Reaching new heights: insights into the genetics of human stature
... pathways, the overlap with monogenic growth and skeletal dysplasia syndromes, links to disease and insights into the genetic architecture of this model polygenic trait. We also discuss the strong probability of finding several hundred more such loci in the near future. Height as a model genetic trai ...
... pathways, the overlap with monogenic growth and skeletal dysplasia syndromes, links to disease and insights into the genetic architecture of this model polygenic trait. We also discuss the strong probability of finding several hundred more such loci in the near future. Height as a model genetic trai ...
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... FIG. 1. Schematic representation of the mouse prosaposin promoter region, transgenic constructs, and distribution of luciferase reporter gene in transgenic mice. (A) Different lengths of the prosaposin promoter 59 flanking DNA were fused with luciferase reporter gene. The promoter regions covered by ...
... FIG. 1. Schematic representation of the mouse prosaposin promoter region, transgenic constructs, and distribution of luciferase reporter gene in transgenic mice. (A) Different lengths of the prosaposin promoter 59 flanking DNA were fused with luciferase reporter gene. The promoter regions covered by ...
Tweak to molecular scissors cuts path to turn on genes —
... time or simultaneously, in large duplications and deletions of DNA linked to autism, says Michael Talkowski, assistant professor of neurology at Harvard Medical School. “For a long time we have been continuously coming up with methods to knock down gene expression, but there have not been really goo ...
... time or simultaneously, in large duplications and deletions of DNA linked to autism, says Michael Talkowski, assistant professor of neurology at Harvard Medical School. “For a long time we have been continuously coming up with methods to knock down gene expression, but there have not been really goo ...
Molecular Evolution of the Avian CHD1 Genes on the Z
... malian Y chromosome) and will thus be present in a copy both on this and on the larger nondegraded sex chromosome (e.g., the X chromosome). As shown for mammals, some of these genes are associated with malespecific or male-enhancing functions and may actually become silenced or deleted from the X ch ...
... malian Y chromosome) and will thus be present in a copy both on this and on the larger nondegraded sex chromosome (e.g., the X chromosome). As shown for mammals, some of these genes are associated with malespecific or male-enhancing functions and may actually become silenced or deleted from the X ch ...
Convergent evolution of complex regulatory
... and B). However, although the profiles shared many interactions, they also displayed differences with contacts observed in digits but not in GT and vice versa (Fig. 2C). Hoxd13 interaction peaks were aligned with both evolutionary conserved noncoding sequences and the GT H3K27 acetylation profile (f ...
... and B). However, although the profiles shared many interactions, they also displayed differences with contacts observed in digits but not in GT and vice versa (Fig. 2C). Hoxd13 interaction peaks were aligned with both evolutionary conserved noncoding sequences and the GT H3K27 acetylation profile (f ...
A Novel Chimeric Low-Molecular-Weight Glutenin
... group, three types of LMW-GS genes were divided into different subgroups but LMW-s- and LMW-m-type genes were shown to have higher homology. These results were consistent with their sequence characteristics and recent reports of An et al. (2006) and Pei et al. (2007). Particularly, the AjkLMW-i gene ...
... group, three types of LMW-GS genes were divided into different subgroups but LMW-s- and LMW-m-type genes were shown to have higher homology. These results were consistent with their sequence characteristics and recent reports of An et al. (2006) and Pei et al. (2007). Particularly, the AjkLMW-i gene ...
Kernels for gene regulatory regions
... the spectrum kernel, is two-fold. First, if all promoters contain common functional motifs and randomly varying nonfunctional motifs, then the signal-to-noise ratio of the relevant regulatory features compared to other irrelevant non-functional features increases by taking the sum (or mean) of indiv ...
... the spectrum kernel, is two-fold. First, if all promoters contain common functional motifs and randomly varying nonfunctional motifs, then the signal-to-noise ratio of the relevant regulatory features compared to other irrelevant non-functional features increases by taking the sum (or mean) of indiv ...
shERWOOD-UltramiR shRNA
... More potent shRNA per gene enables superior hit stratification To benchmark the shERWOOD algorithm design against the early generation TRC and Hannon Elledge (GIPZ) shRNA designs, the Hannon lab (Knott et al 2014) performed a large scale screen using each of these designs to target 2200 genes that w ...
... More potent shRNA per gene enables superior hit stratification To benchmark the shERWOOD algorithm design against the early generation TRC and Hannon Elledge (GIPZ) shRNA designs, the Hannon lab (Knott et al 2014) performed a large scale screen using each of these designs to target 2200 genes that w ...
Guidelines for Gene Expression Patterns papers
... Does it explore a specific Biological event, or function or regulation of a gene(s)? ...
... Does it explore a specific Biological event, or function or regulation of a gene(s)? ...
Characterization and expression of an mRNA encoding a wound
... peptide protects the exposed fracture surface from pathogenic invasion. Some expression is also apparent in nonzone cells and, whilst no cell separation takes place in this tissue, the process of explant generation may provide a sufficient wound signal to promote transcription of the TAB7 gene in th ...
... peptide protects the exposed fracture surface from pathogenic invasion. Some expression is also apparent in nonzone cells and, whilst no cell separation takes place in this tissue, the process of explant generation may provide a sufficient wound signal to promote transcription of the TAB7 gene in th ...
Evolution of the defensin-like gene family in grass genomes
... Plant defensins are small, diverse, cysteine-rich peptides, belonging to a group of pathogenesis-related defense mechanism proteins, which can provide a barrier against a broad range of pathogens. In this study, 51 defensin-like (DEFL) genes in Gramineae, including brachypodium, rice, maize and sorg ...
... Plant defensins are small, diverse, cysteine-rich peptides, belonging to a group of pathogenesis-related defense mechanism proteins, which can provide a barrier against a broad range of pathogens. In this study, 51 defensin-like (DEFL) genes in Gramineae, including brachypodium, rice, maize and sorg ...
SMN1 - IS MU
... • Histones may undergo posttranslational modifications (acetylation, methylation, phosphorylation and ubiquitination). Histone modifications serve as a site for recruitment of chromatin-associating proteins that recognize a specific histone code. • Specific histone modifications are associated with ...
... • Histones may undergo posttranslational modifications (acetylation, methylation, phosphorylation and ubiquitination). Histone modifications serve as a site for recruitment of chromatin-associating proteins that recognize a specific histone code. • Specific histone modifications are associated with ...