Supplementary Material
... examined animals heterozygous for the ok487 allele and a deficiency, sDf23, which deletes the hlh-17/hlh-31 locus (data not shown). We found that these animals were viable, suggesting that ok487 is unlikely to be a loss-of-function mutation in hlh-17. Finally, by sequencing the hlh-17/hlh-31 locus f ...
... examined animals heterozygous for the ok487 allele and a deficiency, sDf23, which deletes the hlh-17/hlh-31 locus (data not shown). We found that these animals were viable, suggesting that ok487 is unlikely to be a loss-of-function mutation in hlh-17. Finally, by sequencing the hlh-17/hlh-31 locus f ...
Gene Regulation in Development and Evolution
... is to distribute a critical regulatory molecule asymmetrically during cell division, thereby ensuring that the daughter cells inherit different amounts of that regulator and thus follow different pathways of development. Typically, the asymmetrically distributed molecule is an mRNA. These mRNAs can ...
... is to distribute a critical regulatory molecule asymmetrically during cell division, thereby ensuring that the daughter cells inherit different amounts of that regulator and thus follow different pathways of development. Typically, the asymmetrically distributed molecule is an mRNA. These mRNAs can ...
Effects of turmeric (Curcuma longa) on the expression
... Ribonucleic acid was extracted from the liver samples (6 samples per treatment) using an RNeasy Midi Kit (Qiagen Inc., Valencia, CA; Settivari et al., 2006), purified using DNase-1 (Ambion Inc., Austin, TX) and phenol:chloroform:isoamyl alcohol (25:24:1), and concentrated using Microcon YM30 filters ...
... Ribonucleic acid was extracted from the liver samples (6 samples per treatment) using an RNeasy Midi Kit (Qiagen Inc., Valencia, CA; Settivari et al., 2006), purified using DNase-1 (Ambion Inc., Austin, TX) and phenol:chloroform:isoamyl alcohol (25:24:1), and concentrated using Microcon YM30 filters ...
Bacteriophage l and Its Relatives
... lysogens can give rise to lysis of other susceptible bacteria, as in the experiment cited above); alternatively, such a cell is said to be lysogenic for the phage in question. A consequence of expression of the repressor by a prophage is that the lysogen carrying the prophage acquires immunity to in ...
... lysogens can give rise to lysis of other susceptible bacteria, as in the experiment cited above); alternatively, such a cell is said to be lysogenic for the phage in question. A consequence of expression of the repressor by a prophage is that the lysogen carrying the prophage acquires immunity to in ...
presentation source
... Apply custom gene-trap vectors to inactivate genes in ES cells and to evaluate the functional importance of these in cardiopulmonary development and disease using computational approaches, expression profiling, in situ hybridization studies, and in select cases in animals. ...
... Apply custom gene-trap vectors to inactivate genes in ES cells and to evaluate the functional importance of these in cardiopulmonary development and disease using computational approaches, expression profiling, in situ hybridization studies, and in select cases in animals. ...
... embryos. 5meC lane = DNA precipitated by antibody against methylated cytosine; IgG = non-specific immunoprecipitation; Input = DNA before immunoprecipitation; - = no antibody control. Specific bands for Kcnq1 and Kcnq1ot1 are indicated; NS = non-specific amplification product. The Kcnq1ot1 promoter ...
Accelerated gene evolution through replication
... Here we identify the ubiquitous (core) genes in Bacillus subtilis and determine that 17% of them are on the lagging strand. We find a higher rate of point mutations in the core genes on the lagging strand compared with those on the leading strand, with this difference being primarily in the amino-ac ...
... Here we identify the ubiquitous (core) genes in Bacillus subtilis and determine that 17% of them are on the lagging strand. We find a higher rate of point mutations in the core genes on the lagging strand compared with those on the leading strand, with this difference being primarily in the amino-ac ...
Supplementary Text - Austin Publishing Group
... addition, the authors also reported involvement of polymorphisms in monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT) genes that modified cognitive impairment and psychiatric symptoms in HD [STR16]. Engineered knock-in mouse model of HD harboring human synteny region of human 6q23-2 ...
... addition, the authors also reported involvement of polymorphisms in monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT) genes that modified cognitive impairment and psychiatric symptoms in HD [STR16]. Engineered knock-in mouse model of HD harboring human synteny region of human 6q23-2 ...
Biomarkers for Epithelial Ovarian Cancers
... large numbers of tumor samples and has provided an opportunity to classify di erent diseases based on characteristic expression patterns (see [3] for a work on di use large B-cell lymphoma (DLBCL), [8] for colon cancer, and [19] for breast cancer). In fact, there were several studies to nd responsi ...
... large numbers of tumor samples and has provided an opportunity to classify di erent diseases based on characteristic expression patterns (see [3] for a work on di use large B-cell lymphoma (DLBCL), [8] for colon cancer, and [19] for breast cancer). In fact, there were several studies to nd responsi ...
Slides
... – Does a motif also appears in the homologous genes of another species? – Strongest evidence – However, will not be able to find species-specific ones ...
... – Does a motif also appears in the homologous genes of another species? – Strongest evidence – However, will not be able to find species-specific ones ...
Gene Section HMGA2 (high mobility group AT-hook 2) in Oncology and Haematology
... In a majority of cases, there is no fusion gene: the breakpoint is located 10 kb up to 100 kb 5' to HMGIC; the recombinational repair gene RAD51B is a candidate to be the partner gene of HMGIC in t(12;14). In two cases (out of 81 primary tumors) exon 7 of RAD51B was fused in frame to either exon 2 o ...
... In a majority of cases, there is no fusion gene: the breakpoint is located 10 kb up to 100 kb 5' to HMGIC; the recombinational repair gene RAD51B is a candidate to be the partner gene of HMGIC in t(12;14). In two cases (out of 81 primary tumors) exon 7 of RAD51B was fused in frame to either exon 2 o ...
1 Meiotic sex chromosome inactivation is disrupted in
... over-expressed in pachytene/diplotene cells but not in the leptotene/zygotene population). We would also expect to observe over-expression in secondary spermatocytes. Consistent with these predictions, six of the seven X-linked genes assayed (86%) were significantly over-expressed in pachytene/dipl ...
... over-expressed in pachytene/diplotene cells but not in the leptotene/zygotene population). We would also expect to observe over-expression in secondary spermatocytes. Consistent with these predictions, six of the seven X-linked genes assayed (86%) were significantly over-expressed in pachytene/dipl ...
What is systems biology? - McGraw Hill Higher Education
... Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 21 ...
... Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 21 ...
DNA Methylation Maintains Allele-specific KIR Gene Expression in
... methylation controls tissue-specific gene expression (14, 15). Consistent with this hypothesis, mammals methylate most cytosines that are part of the mini-palindrome, CpG. DNA methylation correlates with poor gene transcription of the inactive X chromosome of female cells, imprinted genes, transfect ...
... methylation controls tissue-specific gene expression (14, 15). Consistent with this hypothesis, mammals methylate most cytosines that are part of the mini-palindrome, CpG. DNA methylation correlates with poor gene transcription of the inactive X chromosome of female cells, imprinted genes, transfect ...
The Functional Organization of the Vestigial Locus in Drosophila
... (1981b) have proposed that the cell death observed in vg mutants may be the consequence of abnormal positional information in vg wing imaginal discs. Thus, a molecular analysis of vg is important since it may help to elucidate the mechanisms by which positional information in imaginal discs is estab ...
... (1981b) have proposed that the cell death observed in vg mutants may be the consequence of abnormal positional information in vg wing imaginal discs. Thus, a molecular analysis of vg is important since it may help to elucidate the mechanisms by which positional information in imaginal discs is estab ...
Beads on a string Bowater Biochem Soc Trans 2012
... for the interaction of ISW1 on a unit of two nucleosome particles and showed how ISW1 could set the spacing between adjacent nucleosomes. The data from the Richmond laboratory provide support for ATP-dependent remodelling factors as the important driver of nucleosome positioning. The location of nuc ...
... for the interaction of ISW1 on a unit of two nucleosome particles and showed how ISW1 could set the spacing between adjacent nucleosomes. The data from the Richmond laboratory provide support for ATP-dependent remodelling factors as the important driver of nucleosome positioning. The location of nuc ...
Virus-mediated reprogramming of gene expression in plants John A
... are ‘hyper’susceptible to infection by some viruses [18•,37•,38•]. Fourth, double-stranded RNA is a very potent inducer of PTGS [39,40•,41], and most plant viruses have RNA genomes that replicate via a double-stranded RNA intermediate. Fifth, PTGS that is initiated in a few cells can migrate over bo ...
... are ‘hyper’susceptible to infection by some viruses [18•,37•,38•]. Fourth, double-stranded RNA is a very potent inducer of PTGS [39,40•,41], and most plant viruses have RNA genomes that replicate via a double-stranded RNA intermediate. Fifth, PTGS that is initiated in a few cells can migrate over bo ...
Giant chromosomes
... • The paired chromosomes of oocytes in meiosis consist of numerous chromatin loops arranged along an axis . Chiasma formation is visible at various locations. • Each segment of a lampbrush chromosome consists of a series of chromatin loops, originating from an axis and a condensed structure, the chr ...
... • The paired chromosomes of oocytes in meiosis consist of numerous chromatin loops arranged along an axis . Chiasma formation is visible at various locations. • Each segment of a lampbrush chromosome consists of a series of chromatin loops, originating from an axis and a condensed structure, the chr ...
Wk12-DeanApop
... Induction of FasL by HBx Is Mediated by Egr-2 and Egr-3 • FasL expression correlates with Egr-3 expression (Fig. 4A), but not with Egr-1 ...
... Induction of FasL by HBx Is Mediated by Egr-2 and Egr-3 • FasL expression correlates with Egr-3 expression (Fig. 4A), but not with Egr-1 ...
Lab 9: Regulation of lactose metabolism
... and are all transcribed in the same direction into one mRNA molecule. These three genes transcribed together into a single mRNA constitute an operon. The genes, in order from the promoter region, are: 1) lacZ, 2) lacY, and 3) lacA. The lacZ gene codes for ßgalactosidase, the enzyme that is necessary ...
... and are all transcribed in the same direction into one mRNA molecule. These three genes transcribed together into a single mRNA constitute an operon. The genes, in order from the promoter region, are: 1) lacZ, 2) lacY, and 3) lacA. The lacZ gene codes for ßgalactosidase, the enzyme that is necessary ...