Mitochondrial Dynamics
... localizes to the inner surface of the cell membrane at division sites, where it forms a ring structure (Z ring) that enables constriction and scission of the parent into two daughter cells. FtsZ is a GTPase, which can hydrolyze guanosine triphosphate to provide a source of energy. However, it is tho ...
... localizes to the inner surface of the cell membrane at division sites, where it forms a ring structure (Z ring) that enables constriction and scission of the parent into two daughter cells. FtsZ is a GTPase, which can hydrolyze guanosine triphosphate to provide a source of energy. However, it is tho ...
Roles of Arabidopsis PARC6 in Coordination of
... Chloroplast division is driven by the simultaneous constriction of the inner FtsZ ring (Z ring) and the outer DRP5B ring. The assembly and constriction of these rings in Arabidopsis (Arabidopsis thaliana) are coordinated partly through the inner envelope membrane protein ACCUMULATION AND REPLICATION ...
... Chloroplast division is driven by the simultaneous constriction of the inner FtsZ ring (Z ring) and the outer DRP5B ring. The assembly and constriction of these rings in Arabidopsis (Arabidopsis thaliana) are coordinated partly through the inner envelope membrane protein ACCUMULATION AND REPLICATION ...
Molecular Interaction between COP1 and HY5
... COP1. Further deletion analysis of HY5 indicated that although the N-terminal 40 amino acids were essential for HY5 to interact with COP1, they were not sufficient for mediating COP1 interaction. To ensure that the different degrees of interaction observed were not due to differences in protein expr ...
... COP1. Further deletion analysis of HY5 indicated that although the N-terminal 40 amino acids were essential for HY5 to interact with COP1, they were not sufficient for mediating COP1 interaction. To ensure that the different degrees of interaction observed were not due to differences in protein expr ...
REVIEWS - Unisciel
... homologues, H- and X-proteins, all of which are composed of Ig and fibronectin domains, are located here. The functions of these proteins are unknown, but they bind to myosin and are spaced at 43-nm intervals along the filament, which is also the repeat distance of the helix that describes the myosi ...
... homologues, H- and X-proteins, all of which are composed of Ig and fibronectin domains, are located here. The functions of these proteins are unknown, but they bind to myosin and are spaced at 43-nm intervals along the filament, which is also the repeat distance of the helix that describes the myosi ...
Toxoplasma gondii Chitinase Induces Macrophage Activation
... have been described (Table 1), some of their characteristics were elucidated herein: (a) the optimal pH for chitinase activity is usually in the range of 4.0–7.0; (b) the optimal temperature is usually 50°C; and (c) their molecular mass is commonly between 15 and 50 kDa. Our research on a chitinase ...
... have been described (Table 1), some of their characteristics were elucidated herein: (a) the optimal pH for chitinase activity is usually in the range of 4.0–7.0; (b) the optimal temperature is usually 50°C; and (c) their molecular mass is commonly between 15 and 50 kDa. Our research on a chitinase ...
Document
... cattle. Whether the deer transcript shows alternative polyadenylation is not known. The specific functions of exons I and II in the 5’UTR are also unknown. Differential splicing of exon II has not yet been observed, however cattle have a particular alternative splicing at exon I which creates either ...
... cattle. Whether the deer transcript shows alternative polyadenylation is not known. The specific functions of exons I and II in the 5’UTR are also unknown. Differential splicing of exon II has not yet been observed, however cattle have a particular alternative splicing at exon I which creates either ...
SOD is an enzyme with four different types of metal
... SOD is an enzyme with four different types of metal ions, dividing this family into Cu,Zn-, Fe-, Mn- and Ni-SODs. About 2 billion years ago during the oxygenation of biosphere the evolution of SOD and other antioxidant enzymes was probably triggered by production of O2 by photosynthetic organisms. ...
... SOD is an enzyme with four different types of metal ions, dividing this family into Cu,Zn-, Fe-, Mn- and Ni-SODs. About 2 billion years ago during the oxygenation of biosphere the evolution of SOD and other antioxidant enzymes was probably triggered by production of O2 by photosynthetic organisms. ...
Golgins and GTPases, giving identity and structure to the Golgi
... Rab1), it is required for the docking of ER-derived COPIIcoated vesicles with Golgi membranes in an in vitro assay [20,21]. Recent studies on mammalian p115 have suggested a direct interaction with SNARE proteins that catalyze membrane fusion. Not only could p115 bind to certain early Golgi SNARE pr ...
... Rab1), it is required for the docking of ER-derived COPIIcoated vesicles with Golgi membranes in an in vitro assay [20,21]. Recent studies on mammalian p115 have suggested a direct interaction with SNARE proteins that catalyze membrane fusion. Not only could p115 bind to certain early Golgi SNARE pr ...
mexCD-oprJ aeruginosa
... chlorhexidine (CHX), which perturb the cell envelope. Induction of mexCD-oprJ by membrane-damaging agents requires the envelope stress sigma factor AlgU, an indication that MexCD-OprJ is a component of the envelope stress response in P. aeruginosa. In the absence of CHX-mediated envelope stress, the ...
... chlorhexidine (CHX), which perturb the cell envelope. Induction of mexCD-oprJ by membrane-damaging agents requires the envelope stress sigma factor AlgU, an indication that MexCD-OprJ is a component of the envelope stress response in P. aeruginosa. In the absence of CHX-mediated envelope stress, the ...
Fig. - DIGITAL.CSIC, el repositorio institucional
... in response to changes in its association state. The existence of these dynamic compartments driven by phase transitions can alter the local composition and reactivity of FtsZ during its life cycle acting as a nonspecific modulating factor of cell function. Cells are complex entities spatially organ ...
... in response to changes in its association state. The existence of these dynamic compartments driven by phase transitions can alter the local composition and reactivity of FtsZ during its life cycle acting as a nonspecific modulating factor of cell function. Cells are complex entities spatially organ ...
Introduction to GO Annotation
... 2. Computational analyses - Phylogenetic analysis – function (ISS) - Domain analysis 3. Review articles - TAS evidence ...
... 2. Computational analyses - Phylogenetic analysis – function (ISS) - Domain analysis 3. Review articles - TAS evidence ...
Capping protein: new insights into mechanism
... 21.5 kDa that requires a Ca2C-dependent conformational change to enable it to bind its target proteins, which are often substrates of kinase-dependent phosphorylation reactions [27]. S100B has been found to bind tightly (dissociation constant, Kdz0.2–1 mM) to a 12-residue peptide by phage-display st ...
... 21.5 kDa that requires a Ca2C-dependent conformational change to enable it to bind its target proteins, which are often substrates of kinase-dependent phosphorylation reactions [27]. S100B has been found to bind tightly (dissociation constant, Kdz0.2–1 mM) to a 12-residue peptide by phage-display st ...
FUNCTIONAL CONSEQUENCES OF THE DIRECT PHYSICAL CBP/p300
... Clues to the molecular mechanisms of leukemogenesis have been provided by the discovery of non-random chromosomal abnormalities in the leukemic cells. More than half of all leukemias have detectable chromosomal abnormalities by karyotypic analysis (2). Some of these abnormalities are consistently as ...
... Clues to the molecular mechanisms of leukemogenesis have been provided by the discovery of non-random chromosomal abnormalities in the leukemic cells. More than half of all leukemias have detectable chromosomal abnormalities by karyotypic analysis (2). Some of these abnormalities are consistently as ...
THE PHYSICAL NATURE OF F PLASMID TRAI AND
... but there have been many friends and family who have lent their support generously. The first people who I’d like to thank are all the great friends I’ve made in graduate school. Specifically, I want to thank my friend Monica Berrondo, a once fellow graduate student who I met while doing Tae Kwon Do ...
... but there have been many friends and family who have lent their support generously. The first people who I’d like to thank are all the great friends I’ve made in graduate school. Specifically, I want to thank my friend Monica Berrondo, a once fellow graduate student who I met while doing Tae Kwon Do ...
CFTR mutation classifications toward genotype
... (CFTR) gene, also referred to as ABCC7, cause Cystic Fibrosis (CF), a severe autosomal recessive disease. CF affects 1 in 2,500 to 4,500 newborns among the Caucasian population. All other ethnic groups are affected to a lesser extent. In 1989, Francis Collins, Lap-Chee Tsui and John R. Riordan (Kere ...
... (CFTR) gene, also referred to as ABCC7, cause Cystic Fibrosis (CF), a severe autosomal recessive disease. CF affects 1 in 2,500 to 4,500 newborns among the Caucasian population. All other ethnic groups are affected to a lesser extent. In 1989, Francis Collins, Lap-Chee Tsui and John R. Riordan (Kere ...
Collagens, modifying enzymes and their mutations in humans, flies
... of the endoplasmic reticulum, where the main steps in biosynthesis are: (i) cleavage of the signal peptides (not shown); (ii) hydroxylation of certain proline and lysine residues to 4-hydroxyproline, 3-hydroxyproline and hydroxylysine; (iii) glycosylation of some of the hydroxylysine residues to gal ...
... of the endoplasmic reticulum, where the main steps in biosynthesis are: (i) cleavage of the signal peptides (not shown); (ii) hydroxylation of certain proline and lysine residues to 4-hydroxyproline, 3-hydroxyproline and hydroxylysine; (iii) glycosylation of some of the hydroxylysine residues to gal ...
In Vitro Assays Demonstrate That Pollen Tube Organelles Use
... movement. Proteins were extracted by KI treatment from the most active organelle fraction and then analyzed with an ATP-sensitive microtubule binding assay. Proteins isolated by the selective binding to microtubules were tested for the ability to glide microtubules in the in vitro motility assay, fo ...
... movement. Proteins were extracted by KI treatment from the most active organelle fraction and then analyzed with an ATP-sensitive microtubule binding assay. Proteins isolated by the selective binding to microtubules were tested for the ability to glide microtubules in the in vitro motility assay, fo ...
Drosophila unpaired encodes a secreted protein that activates the
... The Janus kinase cascade is a ubiquitous intracellular signaling pathway required for response to many extracellular ligands. The pathway includes receptor-associated tyrosine kinases (JAKs) and their substrate transcription factors, signal transducers and activators of transcription (STATs). The JA ...
... The Janus kinase cascade is a ubiquitous intracellular signaling pathway required for response to many extracellular ligands. The pathway includes receptor-associated tyrosine kinases (JAKs) and their substrate transcription factors, signal transducers and activators of transcription (STATs). The JA ...
Testing of some enzymatic mixtures used for the improvement of
... toluene diisocyanate or bisdiazobenzidine derivatives can be used as cross-linking agents. The yield of immobilized enzyme is used to characterize the immobilization efficiency and is defined as the ratio of immobilized protein based on enzyme offered for binding [4]. The adsorption of an enzyme ont ...
... toluene diisocyanate or bisdiazobenzidine derivatives can be used as cross-linking agents. The yield of immobilized enzyme is used to characterize the immobilization efficiency and is defined as the ratio of immobilized protein based on enzyme offered for binding [4]. The adsorption of an enzyme ont ...
Salmonella pathogenicity island 1 (SPI-1) type III
... requiring a secondary NSS identified as the chaperonebinding domain (CBD). The CBD is located within the first ~140 amino acids of some secreted proteins and harbours the binding site for the cognate chaperone, which is generally required for efficient transport via the T3S apparatus (Ghosh, 2004; L ...
... requiring a secondary NSS identified as the chaperonebinding domain (CBD). The CBD is located within the first ~140 amino acids of some secreted proteins and harbours the binding site for the cognate chaperone, which is generally required for efficient transport via the T3S apparatus (Ghosh, 2004; L ...
Molecular Genetic Analysis of Phototropism in
... Living plants show changes in their growth patterns in response to environmental stimuli such as light, gravity, water, temperature and touch. In 1880, Darwin outlined those various plant movements in detail in his book ‘The Power of Movement in Plants’. He also studied the phototropic response, whi ...
... Living plants show changes in their growth patterns in response to environmental stimuli such as light, gravity, water, temperature and touch. In 1880, Darwin outlined those various plant movements in detail in his book ‘The Power of Movement in Plants’. He also studied the phototropic response, whi ...
Fear-of-intimacy mediated zinc transport controls the
... toxicity in the fly have demonstrated that most of the 17 putative zinc transporters of ...
... toxicity in the fly have demonstrated that most of the 17 putative zinc transporters of ...
The deleterious effect of missense mutations on pre
... ABSTRACT The presence of missense mutations detected during genetic testing makes it difficult to classify their pathogenic effect. It is possible that the predicted amino acid change affects protein function; however, it is also possible that a missense mutation does not act at the protein level b ...
... ABSTRACT The presence of missense mutations detected during genetic testing makes it difficult to classify their pathogenic effect. It is possible that the predicted amino acid change affects protein function; however, it is also possible that a missense mutation does not act at the protein level b ...
Physical and functional link of the leukemia
... far, it has been reported that AML1 is disrupted by other translocations such as t(3;21),3,4 t(12;21),5,6 and t(16;21).7,8 AML1 also has been found to be mutated in familial platelet disorder (FPD) associated with a predisposition to leukemia9 and in sporadic cases of AML and myelodysplastic syndrom ...
... far, it has been reported that AML1 is disrupted by other translocations such as t(3;21),3,4 t(12;21),5,6 and t(16;21).7,8 AML1 also has been found to be mutated in familial platelet disorder (FPD) associated with a predisposition to leukemia9 and in sporadic cases of AML and myelodysplastic syndrom ...
HCM - Cardiology
... • treadmill time / max. O2 cons. didn’t improve ? Placebo effect Pacing In Cardiomyopathy trial …. Similar data ...
... • treadmill time / max. O2 cons. didn’t improve ? Placebo effect Pacing In Cardiomyopathy trial …. Similar data ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.