Imprinted gene expression in hybrids: perturbed
... The developmental establishment and maintenance of imprinting involve complex interactions between cis-regulatory elements and trans-acting factors, some of which are themselves subject to imprinting (Kelsey and Feil, 2013; Wolf, 2013). The transcription factor gene ZAC1 is imprinted in both mice an ...
... The developmental establishment and maintenance of imprinting involve complex interactions between cis-regulatory elements and trans-acting factors, some of which are themselves subject to imprinting (Kelsey and Feil, 2013; Wolf, 2013). The transcription factor gene ZAC1 is imprinted in both mice an ...
The universal reagent for genome tailoring
... control that the remaining loxP site does not create a disturbance in the gene function after the selectable marker is removed. Interestingly, this allele without the marker removal (Fig. 3B) can provide a useful tool for learning more about the function of the gene of interest. If the marker was de ...
... control that the remaining loxP site does not create a disturbance in the gene function after the selectable marker is removed. Interestingly, this allele without the marker removal (Fig. 3B) can provide a useful tool for learning more about the function of the gene of interest. If the marker was de ...
Recruitment of 5! Hoxa genes in the allantois is
... Inactivation of individual Hox genes in mice has revealed that Hoxa13 is the only member required for embryonic survival (Fromental-Ramain et al., 1996; Shaut et al., 2008). Unexpectedly, whereas live Hoxa13–/– embryos can be recovered at embryonic day (E) 14.5 (Fromental-Ramain et al., 1996; Shaut ...
... Inactivation of individual Hox genes in mice has revealed that Hoxa13 is the only member required for embryonic survival (Fromental-Ramain et al., 1996; Shaut et al., 2008). Unexpectedly, whereas live Hoxa13–/– embryos can be recovered at embryonic day (E) 14.5 (Fromental-Ramain et al., 1996; Shaut ...
Symbiotic Sympatric Speciation: Compliance with Interaction
... dynamics of each unit can be stabilized by forming distinct groups with differentiated states in the pheno-space. Here the two differentiated groups are necessary to stabilize each of the dynamics. Otherwise, the developmental process is unstable, and through the interaction the two types are formed ...
... dynamics of each unit can be stabilized by forming distinct groups with differentiated states in the pheno-space. Here the two differentiated groups are necessary to stabilize each of the dynamics. Otherwise, the developmental process is unstable, and through the interaction the two types are formed ...
Sickle Cell Disease and Hemoglobinopathy Screening in Pregnancy
... sickle cell trait carriers (AS) in several studies; however, there are a few studies that have not found an increased rate of pregnancy related complications. A 1983 study by Tuck et. al.10 looked at 334 pregnancies of women with sickle cell trait compared to 717 patients of the same racial and soci ...
... sickle cell trait carriers (AS) in several studies; however, there are a few studies that have not found an increased rate of pregnancy related complications. A 1983 study by Tuck et. al.10 looked at 334 pregnancies of women with sickle cell trait compared to 717 patients of the same racial and soci ...
Conservation of Brachyury (T) genes in amphioxus and vertebrates
... sequences for two reasons. First, both deduced proteins include the N-terminal limit of the conserved T-domain (see below); indeed, the AmBra-1 and mouse Brachyury proteins share three identical amino acids downstream of the deduced translation start site (Fig. 1). Second, AmBra-2 has a perfect matc ...
... sequences for two reasons. First, both deduced proteins include the N-terminal limit of the conserved T-domain (see below); indeed, the AmBra-1 and mouse Brachyury proteins share three identical amino acids downstream of the deduced translation start site (Fig. 1). Second, AmBra-2 has a perfect matc ...
Increased sex chromosome expression and epigenetic
... 2006). However, the X and Y chromosomes are continually remodelled during the transition between meiosis and spermiogenesis, and histone modifications associated with transcriptionally active chromatin [e.g. histone acetylation and histone H3 dimethylated on lysine 4 (H3K4me2)] are also enriched on ...
... 2006). However, the X and Y chromosomes are continually remodelled during the transition between meiosis and spermiogenesis, and histone modifications associated with transcriptionally active chromatin [e.g. histone acetylation and histone H3 dimethylated on lysine 4 (H3K4me2)] are also enriched on ...
mgm1, the earliest sex-specific germline marker in Drosophila
... At this time, nurse cells are fully polytene. Therefore, decisions that lead to the differentiation of polytene nurse cells are taken at a time when esg can be induced in germ cells. In our experiment, we found no evidence for abnormal development of cells that expressed esg. Oogenesis was normal, n ...
... At this time, nurse cells are fully polytene. Therefore, decisions that lead to the differentiation of polytene nurse cells are taken at a time when esg can be induced in germ cells. In our experiment, we found no evidence for abnormal development of cells that expressed esg. Oogenesis was normal, n ...
Capstone project 2015 in pdf format
... 2: The role of PI3K in regulation of muscle stem cells 1: Protein trafficking and its role in diseases such as diabetes 2: Molecular mechanism of synapse formation, function and autism 1: GABAA receptor structure, function and genetics 2: The application of bioinformatics 3: Human Genome and disease ...
... 2: The role of PI3K in regulation of muscle stem cells 1: Protein trafficking and its role in diseases such as diabetes 2: Molecular mechanism of synapse formation, function and autism 1: GABAA receptor structure, function and genetics 2: The application of bioinformatics 3: Human Genome and disease ...
Genetic Etiologies for Phenotypic Diversity in Sickle Cell Anemia
... could be computed[1], When this likelihood was used as a severity score in a candidate gene-based genetic association study, genes involved in oxidative and vascular biology, fatty acid oxidation, and inflammation were associated with severity. Second, one-SNP-at-a-time (SNP, single nucleotide polym ...
... could be computed[1], When this likelihood was used as a severity score in a candidate gene-based genetic association study, genes involved in oxidative and vascular biology, fatty acid oxidation, and inflammation were associated with severity. Second, one-SNP-at-a-time (SNP, single nucleotide polym ...
SALSA MLPA KIT ME003-A1 Tumor suppressor-3 - MRC
... islands upstream of genes for which an altered methylation status in one or more types of tumours has been reported in literature. In case interesting results are obtained by users, it is possible to develop methylation kits specific for a certain tumour in collaboration with MRC-Holland. Interpreta ...
... islands upstream of genes for which an altered methylation status in one or more types of tumours has been reported in literature. In case interesting results are obtained by users, it is possible to develop methylation kits specific for a certain tumour in collaboration with MRC-Holland. Interpreta ...
71 ORGANOGENESIS IN CHRYSANTHEMUM MORIFOLIUM RAMAT
... ■ The morpho-genetical potential has been established to be greater in primary callus cultures derived from stem explants. ■ The callus differentiated into shoots when transferred to MS medium containing 2mg/l K and 0,2 mg/l 2,4 D. ■ The use a combination of a synthetic cytokines such as kinetin in ...
... ■ The morpho-genetical potential has been established to be greater in primary callus cultures derived from stem explants. ■ The callus differentiated into shoots when transferred to MS medium containing 2mg/l K and 0,2 mg/l 2,4 D. ■ The use a combination of a synthetic cytokines such as kinetin in ...
Green Fluorescent Protein-Glucocorticoid Receptor Knockin Mice
... expressed within a cell determines the magnitude and nature of the response to GCs. It has been observed that both overexpression of GR and expression of antisense GR mRNA in transgenic mice alters thymocyte survival in vitro and in vivo (9 –11). Furthermore, the relative ratio of GR to other transc ...
... expressed within a cell determines the magnitude and nature of the response to GCs. It has been observed that both overexpression of GR and expression of antisense GR mRNA in transgenic mice alters thymocyte survival in vitro and in vivo (9 –11). Furthermore, the relative ratio of GR to other transc ...
cis-Regulatory Elements and trans-Acting Factors
... used for renin gene expression studies. Chorion tissue represents the second major site of production, after kidney, in human tissues.10 Moreover, chorionic cells in primary and secondary cultures produce large quantities of renin, predominantly in the prorenin form, and are easily accessible.14 Ren ...
... used for renin gene expression studies. Chorion tissue represents the second major site of production, after kidney, in human tissues.10 Moreover, chorionic cells in primary and secondary cultures produce large quantities of renin, predominantly in the prorenin form, and are easily accessible.14 Ren ...
Replication timing and transcriptional control: beyond
... There are only two mammalian loci for which both replication-timing switches and origin localization have been studied. At the mouse immunoglobulin IgH locus, new origins are activated in pre-B cells when the promoter region of this locus becomes transcriptionally active and switches from late to ea ...
... There are only two mammalian loci for which both replication-timing switches and origin localization have been studied. At the mouse immunoglobulin IgH locus, new origins are activated in pre-B cells when the promoter region of this locus becomes transcriptionally active and switches from late to ea ...
Introduction - bei DuEPublico
... cancer genes are often involved in pathways that regulate growth, apoptosis, angiogenesis and replication. For example, the p53 protein is a transcription factor that inhibits cell growth and stimulates cell death. The p53 pathway (Fig 1-1-b) can be disrupted by point mutation in the p53 gene, or by ...
... cancer genes are often involved in pathways that regulate growth, apoptosis, angiogenesis and replication. For example, the p53 protein is a transcription factor that inhibits cell growth and stimulates cell death. The p53 pathway (Fig 1-1-b) can be disrupted by point mutation in the p53 gene, or by ...
Linköping University Post Print Neuronal Subtype Specification within a Feed-Forward Loops
... regulation of Col from Ap2/3 and Ap4/FMRFa controlled? Finally, the Col feed-forward loop specifies Ap1/Nplp1 fate, and the absence of Col specifies the Ap2/3 fate, but how is the Ap4/FMRFa fate specified (Figure 1C)? Here we find that the Ap cluster neurons are the last four cells to be born, in t ...
... regulation of Col from Ap2/3 and Ap4/FMRFa controlled? Finally, the Col feed-forward loop specifies Ap1/Nplp1 fate, and the absence of Col specifies the Ap2/3 fate, but how is the Ap4/FMRFa fate specified (Figure 1C)? Here we find that the Ap cluster neurons are the last four cells to be born, in t ...
Abnormal anaphase resolution - Journal of Cell Science
... such as: asp, which affect spindle function (Ripoll et al., 1985); mgr, which might be required for spindle pole function (Gonzalez et al., 1988); sqh, which encodes the regulatory light chain of nonmuscle myosin and is involved in cytokinesis (Karess et al., 1991); ck19, which encodes a type I prot ...
... such as: asp, which affect spindle function (Ripoll et al., 1985); mgr, which might be required for spindle pole function (Gonzalez et al., 1988); sqh, which encodes the regulatory light chain of nonmuscle myosin and is involved in cytokinesis (Karess et al., 1991); ck19, which encodes a type I prot ...
Striking pattern of Purkinje cell loss in cerebellum of an ataxic
... 2004). An obvious Purkinje cell degeneration was observed in leaner mice (Herrup and Wilczynski 1982, Frank et al. 2003), but not reported in other Cav2.1 mutant mice. The present study examined histopathologically the cerebellum of tottering mice, and demonstrated an obvious Purkinje cell loss in t ...
... 2004). An obvious Purkinje cell degeneration was observed in leaner mice (Herrup and Wilczynski 1982, Frank et al. 2003), but not reported in other Cav2.1 mutant mice. The present study examined histopathologically the cerebellum of tottering mice, and demonstrated an obvious Purkinje cell loss in t ...
Transcripts of the MHM region on the chicken Z chromosome
... of chickens, consists of approximately 210 tandem repeats of a BamHI 2.2-kb sequence unit. Cytosines of the CpG dinucleotides of this region are extensively methylated on the two Z chromosomes in the male but much less methylated on the single Z chromosome in the female. The state of methylation of ...
... of chickens, consists of approximately 210 tandem repeats of a BamHI 2.2-kb sequence unit. Cytosines of the CpG dinucleotides of this region are extensively methylated on the two Z chromosomes in the male but much less methylated on the single Z chromosome in the female. The state of methylation of ...
Muscle pattern diversification in Drosophila: the story of
... At the onset of metamorphosis, myoblasts from the everting wing imaginal discs swarm over the persistent larval muscles that serve as substrates for the formation of the DLMs (Fig. 2A).(26) Subsequently, each larval muscle splits into two templates, and continued fusion of imaginal myoblasts with th ...
... At the onset of metamorphosis, myoblasts from the everting wing imaginal discs swarm over the persistent larval muscles that serve as substrates for the formation of the DLMs (Fig. 2A).(26) Subsequently, each larval muscle splits into two templates, and continued fusion of imaginal myoblasts with th ...
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... The transgenic mouse lines with mouse prosaposin promoter deletion constructs were 234Luc, 310Luc, 2400Luc, and 2400DLuc (Fig 1A). The tissue specific expression pattern of promoter deletion constructs was reported previously (Sun et al., 2000). The expression pattern for each construct was same amo ...
... The transgenic mouse lines with mouse prosaposin promoter deletion constructs were 234Luc, 310Luc, 2400Luc, and 2400DLuc (Fig 1A). The tissue specific expression pattern of promoter deletion constructs was reported previously (Sun et al., 2000). The expression pattern for each construct was same amo ...
PROCUSTE1 Encodes a Cellulose Synthase Required for Normal
... were frequently found to be linked by a membranous structure not stained by Calcofluor but observable with Congo Red (Figure 2C) or other stains. This structure presumably corresponds to cell membranes surrounding polysaccharidic material. The study of two other alleles ( prc1-3 and prc1-7; data not ...
... were frequently found to be linked by a membranous structure not stained by Calcofluor but observable with Congo Red (Figure 2C) or other stains. This structure presumably corresponds to cell membranes surrounding polysaccharidic material. The study of two other alleles ( prc1-3 and prc1-7; data not ...
LEADING ARTICLE Concurrent disruption of p16INK4a and
... and p53 mutations have been associated with adverse outcome in aggressive lymphomas.10,13 Recently, a novel putative tumor suppressor, ARF (human p14ARF and murine p19ARF), was identified that may provide an important link between p53 and the p16INK4a-Rb pathway.29,30 Expression of ARF, which is ind ...
... and p53 mutations have been associated with adverse outcome in aggressive lymphomas.10,13 Recently, a novel putative tumor suppressor, ARF (human p14ARF and murine p19ARF), was identified that may provide an important link between p53 and the p16INK4a-Rb pathway.29,30 Expression of ARF, which is ind ...