Nucleolar caspase-2: Protecting us from DNA damage
... delineate two pathways of caspase-2 activation and show that, in response to DNA damage, caspase-2 forms a complex with the PIDDosome and NPM1 within the nucleolus. Caspase-2 is a critical component of the cellular machinery designed to remove damaged cells, preventing disease. Consistent with a fun ...
... delineate two pathways of caspase-2 activation and show that, in response to DNA damage, caspase-2 forms a complex with the PIDDosome and NPM1 within the nucleolus. Caspase-2 is a critical component of the cellular machinery designed to remove damaged cells, preventing disease. Consistent with a fun ...
Nat. Struct. Biol. 8, 192-194.
... Fig. 2 Formation of loop domains by an insulator. The diagrams show the chromatin fiber, with the histone octamers shown in gray and the DNA in yellow. As in Fig. 1, the coding regions of two putative genes are shown in blue green, the transcription complex at the promoter is shown by a series of mu ...
... Fig. 2 Formation of loop domains by an insulator. The diagrams show the chromatin fiber, with the histone octamers shown in gray and the DNA in yellow. As in Fig. 1, the coding regions of two putative genes are shown in blue green, the transcription complex at the promoter is shown by a series of mu ...
ARGONAUTE1 Acts in Arabidopsis Root Radial
... To analyze the relationship between AGO1 and SCR in root radial patterning, we generated ago1-101 scr-3 double mutants and examined their cell arrangement at 4 days post-germination (dpg). In wild-type longitudinal sections, two ground tissue cell layers, the cortex and endodermis, appeared as well- ...
... To analyze the relationship between AGO1 and SCR in root radial patterning, we generated ago1-101 scr-3 double mutants and examined their cell arrangement at 4 days post-germination (dpg). In wild-type longitudinal sections, two ground tissue cell layers, the cortex and endodermis, appeared as well- ...
a gene required for vein/intervein formation in wings of Drosophila
... ascending order of severity (Table 1) – all are phenotypically more severe than existing alleles (Lindsley and Zimm, 1992). Two of the alleles are lethal but the basis for the lethality is not yet understood. bs14 behaves as a genetic null in that bs14 homozygotes and bs14/Df(2R)Px2 are both lethal ...
... ascending order of severity (Table 1) – all are phenotypically more severe than existing alleles (Lindsley and Zimm, 1992). Two of the alleles are lethal but the basis for the lethality is not yet understood. bs14 behaves as a genetic null in that bs14 homozygotes and bs14/Df(2R)Px2 are both lethal ...
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... result from bifurcations along the P/D axis (Baker, 1988; Peifer et al., 1990; Couso et al., 1993). Ectopic expression of wg in clones has provided additional insight into wg function in axial patterning of the leg discs. First, wg was shown to be sufficient for specification of a subset of ventral ...
... result from bifurcations along the P/D axis (Baker, 1988; Peifer et al., 1990; Couso et al., 1993). Ectopic expression of wg in clones has provided additional insight into wg function in axial patterning of the leg discs. First, wg was shown to be sufficient for specification of a subset of ventral ...
Get PDF - Wiley Online Library
... The relative mRNA levels of differentially expressed (DE) and housekeeping (HK) genes of six aneuploid cancer lines with large-scale genomic changes identified by SNP/SKY analysis were compared with similar genes in diploid cells. The aneuploid cancer lines had heterogeneous genomic landscapes with ...
... The relative mRNA levels of differentially expressed (DE) and housekeeping (HK) genes of six aneuploid cancer lines with large-scale genomic changes identified by SNP/SKY analysis were compared with similar genes in diploid cells. The aneuploid cancer lines had heterogeneous genomic landscapes with ...
In vitro fertilization (IVF) in mammals: epigenetic and developmental
... He named this process Epigenetics, which is now understood as the conditions that control the expression of genes that are highly influenced by environment. A more precise definition is: “The study of changes in gene function that are mitotically and/or meiotically heritable and that do not entail a ...
... He named this process Epigenetics, which is now understood as the conditions that control the expression of genes that are highly influenced by environment. A more precise definition is: “The study of changes in gene function that are mitotically and/or meiotically heritable and that do not entail a ...
Classification of colorectal cancer based on correlation of clinical
... observed in sporadic adenomas24 and the few such examples found turned out to be mainly derived from patients with Lynch syndrome.25 These findings gave rise to the suggestion that, unlike the adenomas in Lynch syndrome, MSI-H must occur as a relatively late event in sporadic adenomas.21 Why, it may ...
... observed in sporadic adenomas24 and the few such examples found turned out to be mainly derived from patients with Lynch syndrome.25 These findings gave rise to the suggestion that, unlike the adenomas in Lynch syndrome, MSI-H must occur as a relatively late event in sporadic adenomas.21 Why, it may ...
Rapid Selection of Multiple Gene Integrant for the Production of
... Abstract For the rapid selection of higher recombinant hirudin producing strain in a methylotrophic yeast Hansenula polymorpha, a multiple gene integration and dose-dependent selection vector, based on a telomere-associated ARS and a bacterial aminoglycoside 3phosphotransferase (aph) gene, was adopt ...
... Abstract For the rapid selection of higher recombinant hirudin producing strain in a methylotrophic yeast Hansenula polymorpha, a multiple gene integration and dose-dependent selection vector, based on a telomere-associated ARS and a bacterial aminoglycoside 3phosphotransferase (aph) gene, was adopt ...
Many Genomic Regions Are Required for Normal Embryonic
... comprehensive set of chromosomal deficiencies for alterations in the pattern of PCD throughout embryonic development. From a set of 58 deficiencies, which collectively remove ⵑ74% of the genome, four distinct classes were identified. In class I (20 deficiencies), no significant deviation from wild t ...
... comprehensive set of chromosomal deficiencies for alterations in the pattern of PCD throughout embryonic development. From a set of 58 deficiencies, which collectively remove ⵑ74% of the genome, four distinct classes were identified. In class I (20 deficiencies), no significant deviation from wild t ...
Open Access
... the key players or pathways known to be relevant for a given process in one model organism in an evolutionarily distantly related species. As outlined by Sommer [2] this often leads to an almost descriptive list of the molecular inventories rather than a functional understanding. For a functional ev ...
... the key players or pathways known to be relevant for a given process in one model organism in an evolutionarily distantly related species. As outlined by Sommer [2] this often leads to an almost descriptive list of the molecular inventories rather than a functional understanding. For a functional ev ...
Gene Section NACC1 (nucleus accumbens associated 1, BEN
... inactivating Nac1 function; as such manipulation in SKOV3 ovarian cancer cells and HeLa cervical cancer cells was demonstrated to be sufficient to inhibit the ...
... inactivating Nac1 function; as such manipulation in SKOV3 ovarian cancer cells and HeLa cervical cancer cells was demonstrated to be sufficient to inhibit the ...
Gene Section SIL (SCL/TAL1 interrupting locus) Atlas of Genetics and Cytogenetics
... © 2006 Atlas of Genetics and Cytogenetics in Oncology and Haematology ...
... © 2006 Atlas of Genetics and Cytogenetics in Oncology and Haematology ...
Chapter 3
... the evolutionary origin and homology of the mesoderm across metazoans remains a subject of debate. A comparative analysis of genes involved in mesoderm specification and differentiation across animal taxa may shed light on the homology of the mesoderm. Thus far, most of the knowledge about genes inv ...
... the evolutionary origin and homology of the mesoderm across metazoans remains a subject of debate. A comparative analysis of genes involved in mesoderm specification and differentiation across animal taxa may shed light on the homology of the mesoderm. Thus far, most of the knowledge about genes inv ...
PDF - The Journal of Immunology
... The intestinal epithelium forms a first line of innate host defense by secretion of proteins with antimicrobial activity against microbial infection. Despite the extensive studies on the antimicrobial host defense in many gastrointestinal tracts, little is known about the antimicrobial defense syste ...
... The intestinal epithelium forms a first line of innate host defense by secretion of proteins with antimicrobial activity against microbial infection. Despite the extensive studies on the antimicrobial host defense in many gastrointestinal tracts, little is known about the antimicrobial defense syste ...
The chromatin remodelling factor Brg1 interacts with catenin to
... receptor-mediated transactivation of an MMTV reporter gene (data not shown). Importantly, the effects of b-catenin and Brg-1 on the Siamois reporter gene activity were strictly dependent upon the presence of optimal Tcfbinding sites within the Siamois promoter, indicating that binding of Tcf to targ ...
... receptor-mediated transactivation of an MMTV reporter gene (data not shown). Importantly, the effects of b-catenin and Brg-1 on the Siamois reporter gene activity were strictly dependent upon the presence of optimal Tcfbinding sites within the Siamois promoter, indicating that binding of Tcf to targ ...
Two ParaHox genes, SpLox and SpCdx, interact to
... SpLox gene are revealed by the analysis of the expression of a set of genes involved in endoderm specification. Two such interactions have been analyzed in more detail: one involving the midgut marker gene Endo16, and another involving the other endodermally expressed ParaHox gene, SpCdx. We find th ...
... SpLox gene are revealed by the analysis of the expression of a set of genes involved in endoderm specification. Two such interactions have been analyzed in more detail: one involving the midgut marker gene Endo16, and another involving the other endodermally expressed ParaHox gene, SpCdx. We find th ...
Patterns of gene action in plant development revealed by enhancer
... McClintock's investigations on alterations in the patterns of "gene action" in maize kernels led to the discovery of transposable elements (McClintock 1950). Subsequently, transposable elements have been found in almost all organisms examined and are believed to constitute a major agent for the gene ...
... McClintock's investigations on alterations in the patterns of "gene action" in maize kernels led to the discovery of transposable elements (McClintock 1950). Subsequently, transposable elements have been found in almost all organisms examined and are believed to constitute a major agent for the gene ...
Epigenetic inheritance of acquired traits through sperm RNAs and
... (tsRNAGly(GCC))11 could change early embryonic gene expression, indicating that sperm tsRNAs play an active part in the transmission of paternally acquired traits by reshaping early embryonic development. A recent study revealed that sperm tsRNAs show a dramatic increase in abundance during late spe ...
... (tsRNAGly(GCC))11 could change early embryonic gene expression, indicating that sperm tsRNAs play an active part in the transmission of paternally acquired traits by reshaping early embryonic development. A recent study revealed that sperm tsRNAs show a dramatic increase in abundance during late spe ...
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... The maternal sporophyte affects the provision of nutrients to the endosperm and controls seed size via the integuments (Garcia et al., 2005; Ingouff et al., 2006; Schruff et al., 2006). Deregulation of such transfer activities causes maternal sporophytic effects on seed development (Cheng, 1996; Gut ...
... The maternal sporophyte affects the provision of nutrients to the endosperm and controls seed size via the integuments (Garcia et al., 2005; Ingouff et al., 2006; Schruff et al., 2006). Deregulation of such transfer activities causes maternal sporophytic effects on seed development (Cheng, 1996; Gut ...
Pepsin-Mediated Processing of the Cytoplasmic Histone H2A to
... The intestinal epithelium forms a first line of innate host defense by secretion of proteins with antimicrobial activity against microbial infection. Despite the extensive studies on the antimicrobial host defense in many gastrointestinal tracts, little is known about the antimicrobial defense syste ...
... The intestinal epithelium forms a first line of innate host defense by secretion of proteins with antimicrobial activity against microbial infection. Despite the extensive studies on the antimicrobial host defense in many gastrointestinal tracts, little is known about the antimicrobial defense syste ...
Drawings of Chromosome Movement During Meiosis
... mitosis and meiosis. Pages 5 and 6 of this exercise contain drawings of cells during different phases of mitosis and meiosis. You will draw chromosomes in each of the circles to represent the chromosomes of a hypothetical organism with a diploid number of 4 (2N = 4). Different colors will be used to ...
... mitosis and meiosis. Pages 5 and 6 of this exercise contain drawings of cells during different phases of mitosis and meiosis. You will draw chromosomes in each of the circles to represent the chromosomes of a hypothetical organism with a diploid number of 4 (2N = 4). Different colors will be used to ...
Fulltext PDF - Indian Academy of Sciences
... zeste 12, a Polycomb group (PcG) gene of enormous importance in the development of the fruit fly Drosophila melanogaster. In Drosophila, PcG proteins generally act by remodelling chromatin structure and mediating the silencing of homeotic genes. VRN2 does not appear to be required for the vernalizat ...
... zeste 12, a Polycomb group (PcG) gene of enormous importance in the development of the fruit fly Drosophila melanogaster. In Drosophila, PcG proteins generally act by remodelling chromatin structure and mediating the silencing of homeotic genes. VRN2 does not appear to be required for the vernalizat ...
1955: Kinetin Arrives. The 50th Anniversary of a New Plant Hormone
... derivative. Some of this confidence came from a chemical test that he had performed earlier for the presence of indoleacetic acid and other indole compounds in the active fraction. At that time, many growth phenomena were regarded as being influenced or even caused by auxin. Therefore, Miller had te ...
... derivative. Some of this confidence came from a chemical test that he had performed earlier for the presence of indoleacetic acid and other indole compounds in the active fraction. At that time, many growth phenomena were regarded as being influenced or even caused by auxin. Therefore, Miller had te ...
Organization of chromosomes in the interphase cell - UvA-DARE
... compartment. Just before it is replicated, this region expands and moves towards the nuclear- interior (Li et al, 1998). It is not yet clear why the onset of replication results in repositioning, because late in S-phase, when the HSR replicates, DNA replication takes also place at the nuclear periph ...
... compartment. Just before it is replicated, this region expands and moves towards the nuclear- interior (Li et al, 1998). It is not yet clear why the onset of replication results in repositioning, because late in S-phase, when the HSR replicates, DNA replication takes also place at the nuclear periph ...