Organization of chromosomes in the interphase cell - UvA-DARE
... compartment. Just before it is replicated, this region expands and moves towards the nuclear- interior (Li et al, 1998). It is not yet clear why the onset of replication results in repositioning, because late in S-phase, when the HSR replicates, DNA replication takes also place at the nuclear periph ...
... compartment. Just before it is replicated, this region expands and moves towards the nuclear- interior (Li et al, 1998). It is not yet clear why the onset of replication results in repositioning, because late in S-phase, when the HSR replicates, DNA replication takes also place at the nuclear periph ...
Gene Section MINA (MYC induced nuclear antigen) Atlas of Genetics and Cytogenetics
... expression, whereas its knockdown in primary CD4(+) T cells led to IL4 de-repression. Therefore MINA controls helper T cell differentiation through an IL4regulatory pathway (Okamoto et al,. 2009). These findings suggest that MINA may play a role on carcinogenesis also in the field of cancer immunolo ...
... expression, whereas its knockdown in primary CD4(+) T cells led to IL4 de-repression. Therefore MINA controls helper T cell differentiation through an IL4regulatory pathway (Okamoto et al,. 2009). These findings suggest that MINA may play a role on carcinogenesis also in the field of cancer immunolo ...
The hair follicle and its stem cells as drug delivery targets
... The hair follicle is a skin appendage with a complex structure containing many cell types that produce highly specialised proteins. The hair follicle is in a continuous cycle: anagen is the hair growth phase, catogen the involution phase and telogen is the resting phase. The follicle offers many pot ...
... The hair follicle is a skin appendage with a complex structure containing many cell types that produce highly specialised proteins. The hair follicle is in a continuous cycle: anagen is the hair growth phase, catogen the involution phase and telogen is the resting phase. The follicle offers many pot ...
The relationship between higher‑order chromatin structure and
... have reasonable models for. However, it is clear from electron microscopy studies that a lot of mammalian chromatin is packaged into levels beyond this. The few assays that we have for tertiary levels of chromatin structure are, in the main, cytological. There does seem to be a link between chromati ...
... have reasonable models for. However, it is clear from electron microscopy studies that a lot of mammalian chromatin is packaged into levels beyond this. The few assays that we have for tertiary levels of chromatin structure are, in the main, cytological. There does seem to be a link between chromati ...
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... (Eif2aS51A) that prevents eIF2␣ phosphorylation. Together, these observations prove that eIF2(␣P) dephosphorylation is the common critical function of the PPP1R15 family of phosphatase regulatory subunits in mouse embryogenesis. The arrest of embryos lacking both PPP1r15 genes at the preimplantation ...
... (Eif2aS51A) that prevents eIF2␣ phosphorylation. Together, these observations prove that eIF2(␣P) dephosphorylation is the common critical function of the PPP1R15 family of phosphatase regulatory subunits in mouse embryogenesis. The arrest of embryos lacking both PPP1r15 genes at the preimplantation ...
Invagination centers within the Drosophila stomatogastric nervous
... Fig. 1. The SNS of late Drosophila embryos. (A) Diagram illustrating the components of the SNS (red) and their relative positions with respect to morphological landmarks such as different portions of the gut and brain as seen by mAb22C10 or anti-fasciclin II antibody stainings (B-H); anterior is lef ...
... Fig. 1. The SNS of late Drosophila embryos. (A) Diagram illustrating the components of the SNS (red) and their relative positions with respect to morphological landmarks such as different portions of the gut and brain as seen by mAb22C10 or anti-fasciclin II antibody stainings (B-H); anterior is lef ...
Gene Section CPM (carboxypeptidase M) Atlas of Genetics and Cytogenetics
... factor binding sites were identified in the 5' region flanking the proximal initiation sites, including a vitamin D3 responsive element and Sp1. The distal promoter (~ 30 kb upstream of the coding region) differs from the proximal promoter in that it mainly consists of repetitive elements and lacks ...
... factor binding sites were identified in the 5' region flanking the proximal initiation sites, including a vitamin D3 responsive element and Sp1. The distal promoter (~ 30 kb upstream of the coding region) differs from the proximal promoter in that it mainly consists of repetitive elements and lacks ...
A Customized Gene Expression Microarray
... believed to result from an aberrant cellulose synthase (CesA) gene (Yan et al., 2007). Overall, a large number of different genes, possibly more than 20, have been implicated in various brittle stem mutants or in mutants with reduced cellulose content (Supplemental Table S1), although in most cases ...
... believed to result from an aberrant cellulose synthase (CesA) gene (Yan et al., 2007). Overall, a large number of different genes, possibly more than 20, have been implicated in various brittle stem mutants or in mutants with reduced cellulose content (Supplemental Table S1), although in most cases ...
Birefringence imaging of spermatozoa, spindle and zona pellucida
... Impl./Preg.-rate p g Abortion rate No clear effect in IVF ...
... Impl./Preg.-rate p g Abortion rate No clear effect in IVF ...
A gene expression atlas of a bicoid-depleted
... advantage over CRISPR-Cas9 genome editing (Ren et al., 2013). We crossed maternal triple driver Gal4 (MTD-Gal4) females with UAS-shRNA-bcd males and collected embryos laid by MTD-Gal4/ UAS-shRNA-bcd females (Fig. 1A). Mutant and shRNA embryos exhibited similar phenotypes (Fig. 1B) and phenotypic var ...
... advantage over CRISPR-Cas9 genome editing (Ren et al., 2013). We crossed maternal triple driver Gal4 (MTD-Gal4) females with UAS-shRNA-bcd males and collected embryos laid by MTD-Gal4/ UAS-shRNA-bcd females (Fig. 1A). Mutant and shRNA embryos exhibited similar phenotypes (Fig. 1B) and phenotypic var ...
WUS and STM in shoot meristem regulation
... phenotype, STM appears to maintain cells in an undifferentiated state, before they are incorporated into leaf primordia. To test whether STM was sufficient to suppress differentiation, we expressed STM ectopically in leaf primordia, using the pOpL two-component system (Moore et al., 1998; see Materi ...
... phenotype, STM appears to maintain cells in an undifferentiated state, before they are incorporated into leaf primordia. To test whether STM was sufficient to suppress differentiation, we expressed STM ectopically in leaf primordia, using the pOpL two-component system (Moore et al., 1998; see Materi ...
Mutations in SIN4 and RGR1 Cause Constitutive Expression of MAL
... was constructed as follows. Plasmid YIp365-I61 (Danzi et al. 2000) carrying the MAL61 promoter was digested with EcoRI and Sal I to liberate a 0.9-kb fragment containing base pairs ⫺874 to ⫺1 of the MAL61 promoter. This was subcloned into vector pUN30 (Elledge and Davis 1988), forming pUN30MAL61pro. ...
... was constructed as follows. Plasmid YIp365-I61 (Danzi et al. 2000) carrying the MAL61 promoter was digested with EcoRI and Sal I to liberate a 0.9-kb fragment containing base pairs ⫺874 to ⫺1 of the MAL61 promoter. This was subcloned into vector pUN30 (Elledge and Davis 1988), forming pUN30MAL61pro. ...
Cell wall of Trichoderma
... Carbohydrate polymers are the main components of the fungal cell wall however, mannosylated proteins make up about 40% of the yeast cell wall [44]. It has been suggested that defects in protein glycosylation could impair the cell wall integrity by influencing folding and activity of enzymes catalys ...
... Carbohydrate polymers are the main components of the fungal cell wall however, mannosylated proteins make up about 40% of the yeast cell wall [44]. It has been suggested that defects in protein glycosylation could impair the cell wall integrity by influencing folding and activity of enzymes catalys ...
The B-cell maturation factor Blimp-1 specifies vertebrate slow
... previously described role of Blimp-1 in regulating vertebrate gastrulation15. Examination of the slow muscle lineage in these morphants at early stages of somitogenesis showed that its development was completely impaired, as indicated by the total absence of slow MyHC; this contrasts with ubotp39 mu ...
... previously described role of Blimp-1 in regulating vertebrate gastrulation15. Examination of the slow muscle lineage in these morphants at early stages of somitogenesis showed that its development was completely impaired, as indicated by the total absence of slow MyHC; this contrasts with ubotp39 mu ...
Protocadherin-1: epithelial barrier dysfunction in asthma and eczema Grissel Faura Tellez
... not been extensively characterised to date. In 2009, PCDH1 was identified as a susceptibility gene for bronchial hyperresponsiveness (BHR) and asthma in children and adults. Subsequently, PCDH1 was shown to be expressed in epithelial cells of the airway [5, 9] and the skin [12]. In four genetic asso ...
... not been extensively characterised to date. In 2009, PCDH1 was identified as a susceptibility gene for bronchial hyperresponsiveness (BHR) and asthma in children and adults. Subsequently, PCDH1 was shown to be expressed in epithelial cells of the airway [5, 9] and the skin [12]. In four genetic asso ...
Intrinsic Regulation of Cambial Growth
... Intrinsic Regulation of Cambial Growth standing attitude that research unable to solve “real world” forestry problems in the short term falls within the realm of “toy research” (Horn 1880; Sprague and Sprague 1976). Some research areas relevant to secondary growth nevertheless have begun to flouris ...
... Intrinsic Regulation of Cambial Growth standing attitude that research unable to solve “real world” forestry problems in the short term falls within the realm of “toy research” (Horn 1880; Sprague and Sprague 1976). Some research areas relevant to secondary growth nevertheless have begun to flouris ...
here - FasterDB
... nucleotides of its intronic neighborhood on both sides, motifs corresponding to PTB binding sites are represented by yellow lines. The sequence of each exon can be retrieved by clicking on it. Furthermore, clicking on “Motifs” in the blue panel, allows displaying exact position of each motif and its ...
... nucleotides of its intronic neighborhood on both sides, motifs corresponding to PTB binding sites are represented by yellow lines. The sequence of each exon can be retrieved by clicking on it. Furthermore, clicking on “Motifs” in the blue panel, allows displaying exact position of each motif and its ...
METHODS FOR FEMALE MAMMALIAN SPERMATOGENESIS AND
... gamete-of-origin-, and therefore parent-of-origin-,dependent modification of the genome, i.e., changes in DNA function without changes in DNA sequences. Typically, all humans have pairs of genes, one on each chromosome inherited from each parent, that are both expressed in cells. One class of imprin ...
... gamete-of-origin-, and therefore parent-of-origin-,dependent modification of the genome, i.e., changes in DNA function without changes in DNA sequences. Typically, all humans have pairs of genes, one on each chromosome inherited from each parent, that are both expressed in cells. One class of imprin ...
Prevention of DNA Rereplication Through a Meiotic Recombination
... meiosis in S. cerevisiae (Buhler et al. 2007; Pan et al. 2011), with a number of controls in place to ensure that each of the 16 chromosomes sustains at least one event (Youds and Boulton 2011). Each DSB is initially processed to generate 3’-single-stranded DNA overhangs that can invade the homo ...
... meiosis in S. cerevisiae (Buhler et al. 2007; Pan et al. 2011), with a number of controls in place to ensure that each of the 16 chromosomes sustains at least one event (Youds and Boulton 2011). Each DSB is initially processed to generate 3’-single-stranded DNA overhangs that can invade the homo ...
Diagnostic Testing for Prader-Willi and Angelman
... utilizing SNRPN (small nuclear ribonucleoprotein N) and alpha-satellite DNA probes. Approximately 28% of cases of PWS are due to maternal uniparental disomy (UPD). This abnormality can best be documented using microsatellite probes. Less than 2% of cases have an abnormality in the imprinting process ...
... utilizing SNRPN (small nuclear ribonucleoprotein N) and alpha-satellite DNA probes. Approximately 28% of cases of PWS are due to maternal uniparental disomy (UPD). This abnormality can best be documented using microsatellite probes. Less than 2% of cases have an abnormality in the imprinting process ...
Telomere Shortening and Tumor Formation by Mouse Cells Lacking
... Telomerase activity was detected in mTR+/+ and mTR+/MEF cultures and S100 extracts → TRAP assays showed the absence of telomerase activity in mTR-/- embryonic fibroblasts and adult mice ...
... Telomerase activity was detected in mTR+/+ and mTR+/MEF cultures and S100 extracts → TRAP assays showed the absence of telomerase activity in mTR-/- embryonic fibroblasts and adult mice ...
Structures in the lac
... 3. goal at Level 3: testing knowledge by giving mutant cells and identifying the mutant gene in the lac operon by running tests and performing assays Introduction: In Prokaryotic (bacteria) cells, gene transcription is regulated by controlling expression of the operon. An operon is a part of the chr ...
... 3. goal at Level 3: testing knowledge by giving mutant cells and identifying the mutant gene in the lac operon by running tests and performing assays Introduction: In Prokaryotic (bacteria) cells, gene transcription is regulated by controlling expression of the operon. An operon is a part of the chr ...
Two enhancer regions in the mouse En-2 locus
... CNS, En-2 is expressed in cells surrounding the developing pituitary (Davis et al., 1988, 1991). In addition, immunohistochemical analysis using a polyclonal antiserum (aEnhb-1) that detects both En-1 and En-2 protein has shown that one or both genes are expressed in presumptive myoblasts within the ...
... CNS, En-2 is expressed in cells surrounding the developing pituitary (Davis et al., 1988, 1991). In addition, immunohistochemical analysis using a polyclonal antiserum (aEnhb-1) that detects both En-1 and En-2 protein has shown that one or both genes are expressed in presumptive myoblasts within the ...
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... was initially mapped onto a separate chromosome (Sarin et al., 2007), yet further analysis revealed that the SNP marker used for this analysis, F32B5, provided misleading mapping data. ot190 was found to be allelic to lsy-9 by allele sequencing and complementation tests. ot247 was placed into a dist ...
... was initially mapped onto a separate chromosome (Sarin et al., 2007), yet further analysis revealed that the SNP marker used for this analysis, F32B5, provided misleading mapping data. ot190 was found to be allelic to lsy-9 by allele sequencing and complementation tests. ot247 was placed into a dist ...
CpG Mutation Rates in the Human Genome Are
... shown directly that single-base mismatches dramatically accelerate the rate of cytosine deamination in vivo (Frederico, Kunkel, and Shaw 1990,1993). Individual internal base pairs within DNA double helixes remain paired for only a few milliseconds (Leroy et al. 1988). It is clear that these base pai ...
... shown directly that single-base mismatches dramatically accelerate the rate of cytosine deamination in vivo (Frederico, Kunkel, and Shaw 1990,1993). Individual internal base pairs within DNA double helixes remain paired for only a few milliseconds (Leroy et al. 1988). It is clear that these base pai ...