Some Calpain History- Part 2: GENETICS and EVOLUTION
... The information for calpain genetics is organized by genes for component subunits of calpain-1 (Capn1 and Capns1), calpain-2 (Capn2 and Capns1) and calpastatin (Cast) Capn3 – a genetic link to human disease- Limb-Girdle Muscular Dystrophy type IIA Capn10- a genetic link to human disease- type ...
... The information for calpain genetics is organized by genes for component subunits of calpain-1 (Capn1 and Capns1), calpain-2 (Capn2 and Capns1) and calpastatin (Cast) Capn3 – a genetic link to human disease- Limb-Girdle Muscular Dystrophy type IIA Capn10- a genetic link to human disease- type ...
Model information sheet - EU
... Therefore the 129/OlaHsd strain is renamed into 129P2/OlaHsd and 129/SvHsd is renamed into 129S2/ SvHsd. The choice of a particular substrain may be of critical importance for a particular project. ...
... Therefore the 129/OlaHsd strain is renamed into 129P2/OlaHsd and 129/SvHsd is renamed into 129S2/ SvHsd. The choice of a particular substrain may be of critical importance for a particular project. ...
Getting a Transcription Factor to Only One Nucleus Following Mitosis
... he growth and development of all eukaryotes depends on the process of asymmetric cell division, in which a single cell gives rise to two genetically identical cells that adopt distinct fates [1,2]. Asymmetry occurs when two cells are exposed to different environmental stimuli or when specific mRNAs ...
... he growth and development of all eukaryotes depends on the process of asymmetric cell division, in which a single cell gives rise to two genetically identical cells that adopt distinct fates [1,2]. Asymmetry occurs when two cells are exposed to different environmental stimuli or when specific mRNAs ...
Genome Biology - Department of Computer Science and
... previous studies. One set of PSSMs were discovered using sequence analysis based method, basically looking for enriched motifs in the DNA regions upstream of all yeast ORFs [20]. From ~5,600 upstream sequences a total of 666 motifs have been discovered, among which 48 could be associated with known ...
... previous studies. One set of PSSMs were discovered using sequence analysis based method, basically looking for enriched motifs in the DNA regions upstream of all yeast ORFs [20]. From ~5,600 upstream sequences a total of 666 motifs have been discovered, among which 48 could be associated with known ...
Thetitanmutants ofArabidopsisare disrupted in mitosis and cell cycle
... Identification of titan mutants Over 500 mutants disrupted in embryogenesis have been isolated and characterized in Arabidopsis (Goldberg et al., 1994; Jürgens et al., 1994; Meinke, 1995). The 250 emb mutants in our collection were originally placed into different classes based on terminal phenotyp ...
... Identification of titan mutants Over 500 mutants disrupted in embryogenesis have been isolated and characterized in Arabidopsis (Goldberg et al., 1994; Jürgens et al., 1994; Meinke, 1995). The 250 emb mutants in our collection were originally placed into different classes based on terminal phenotyp ...
Nutrigenomics in the Patient Care Process: Figuring Out the Puzzle
... and as coenzyme or cosubstrate in synthesis of DNA, RNA & amino acids • C677T - associated with cardiovascular problems reduced conversion of homocysteine to methionine; also associated with increased male infertility and sperm DNA alteration • A1298C - associated with neurological/cognitive problem ...
... and as coenzyme or cosubstrate in synthesis of DNA, RNA & amino acids • C677T - associated with cardiovascular problems reduced conversion of homocysteine to methionine; also associated with increased male infertility and sperm DNA alteration • A1298C - associated with neurological/cognitive problem ...
fragile x dna testing: a guide for physicians and families
... Among the millions of DNA fragments that result are some containing the section of the FMR1 gene with the CGG repeat. When there is no mutation, these FMR1 fragments are of a single known size. If a mutation is present, the fragments are longer. Furthermore, fragments from FMR1 genes that are methyl ...
... Among the millions of DNA fragments that result are some containing the section of the FMR1 gene with the CGG repeat. When there is no mutation, these FMR1 fragments are of a single known size. If a mutation is present, the fragments are longer. Furthermore, fragments from FMR1 genes that are methyl ...
A conserved blueprint for the eye? - treisman lab
... salivary duct (eyg) and the intermediate leg segments (dac).(2,3,5,6,8,21–23) Clearly, their expression is not sufficient to trigger eye development in these sites. toy, ey, eya, so, and dac only induce ectopic eye development in other imaginal discs, suggesting that additional factors present in im ...
... salivary duct (eyg) and the intermediate leg segments (dac).(2,3,5,6,8,21–23) Clearly, their expression is not sufficient to trigger eye development in these sites. toy, ey, eya, so, and dac only induce ectopic eye development in other imaginal discs, suggesting that additional factors present in im ...
Tying the knot: linking cytokinesis to the nuclear cycle
... assembly. Two potential effectors are the actomyosin ring components Plo1p and the SH3-domain-containing phosphoprotein Cdc15p, since ectopic overproduction of Plo1p and Cdc15p leads to actomyosin ring assembly in G2-arrested cells (Okhura et al., 1995; Fankhauser et al., 1995). Deletion of Plo1p re ...
... assembly. Two potential effectors are the actomyosin ring components Plo1p and the SH3-domain-containing phosphoprotein Cdc15p, since ectopic overproduction of Plo1p and Cdc15p leads to actomyosin ring assembly in G2-arrested cells (Okhura et al., 1995; Fankhauser et al., 1995). Deletion of Plo1p re ...
PDF
... and Sd heterozygotes was investigated. Double heterozygous mice carrying both mutations (Sd/+, Uns/+) were much more severely affected than either of the single heterozygotes (Fig. 1A-D). Although in the single heterozygotes the vertebral bodies were only slightly affected in the thoracolumbar regio ...
... and Sd heterozygotes was investigated. Double heterozygous mice carrying both mutations (Sd/+, Uns/+) were much more severely affected than either of the single heterozygotes (Fig. 1A-D). Although in the single heterozygotes the vertebral bodies were only slightly affected in the thoracolumbar regio ...
Pierre MADL Div. of Material Sciences Dep
... which bring the phenotype into being”. Epigenetics appears in the literature as far back as the mid 19th century, although the conceptual origins date back to Aristotle (384-322 BC). He believed in epigenesis: the development of individual organic form from the unformed. This controversial view was ...
... which bring the phenotype into being”. Epigenetics appears in the literature as far back as the mid 19th century, although the conceptual origins date back to Aristotle (384-322 BC). He believed in epigenesis: the development of individual organic form from the unformed. This controversial view was ...
Do gametes woo? Evidence for non-random unions at
... one of these assumptions. Many life stages and events such as gametogenesis, fertilization, embryogenesis and post-natal development occur in the interim between mating and offspring surveys, any of which could lead to departures from expectations. Indeed, when Castle-Little considerations are appli ...
... one of these assumptions. Many life stages and events such as gametogenesis, fertilization, embryogenesis and post-natal development occur in the interim between mating and offspring surveys, any of which could lead to departures from expectations. Indeed, when Castle-Little considerations are appli ...
Imprinting capacity of gamete lineages in C. elegans
... MELLO 1995). Although a fraction of the mosaicism is due to mitotic loss of the extrachromosomal array, substantial mosaicism is observed even in the majority of transgenic lines harboring arrays that have integrated into the chromosome and thus should be present in every cell. Patterns of expressin ...
... MELLO 1995). Although a fraction of the mosaicism is due to mitotic loss of the extrachromosomal array, substantial mosaicism is observed even in the majority of transgenic lines harboring arrays that have integrated into the chromosome and thus should be present in every cell. Patterns of expressin ...
The Origin and Development of Neural Crest
... support of this theory, single neural crest cells that are marked by dye injections in mouse dorsal neural tubes give rise to multiple lineages (13). In addition, individual neural crest cells in culture form mixed colonies of differentiated cells (14,15). After the neural crest cells leave the migr ...
... support of this theory, single neural crest cells that are marked by dye injections in mouse dorsal neural tubes give rise to multiple lineages (13). In addition, individual neural crest cells in culture form mixed colonies of differentiated cells (14,15). After the neural crest cells leave the migr ...
New Developments in the Embryology Laboratory
... nucleus (small nuclear RNAs)and in the nucleolus (small nucleolar RNAs) are important components of transcriptomics • Proportion of mRNAs in a transcriptome account for only 1-2% of total RNA content in somatic cells ...
... nucleus (small nuclear RNAs)and in the nucleolus (small nucleolar RNAs) are important components of transcriptomics • Proportion of mRNAs in a transcriptome account for only 1-2% of total RNA content in somatic cells ...
Albugo tragopogonis - ISA – International Sunflower Association
... RHA 276 and HA 380. Additionally, genotypes susceptible to petiole infection may have lesions limited to the petiole itself, or in cases of extreme petiole susceptibility, there may be large lesions in the axils, as exemplified by RHA 362, HA 207, and HA 384. The extreme case of petiole susceptibil ...
... RHA 276 and HA 380. Additionally, genotypes susceptible to petiole infection may have lesions limited to the petiole itself, or in cases of extreme petiole susceptibility, there may be large lesions in the axils, as exemplified by RHA 362, HA 207, and HA 384. The extreme case of petiole susceptibil ...
Ectopic segmentation gene expression and
... deleted in pair-rule HSF embryos are segmental or parasegmental. Both phasings predict similar ventral cuticular phenotypes as the losses of, pT2 (posterior second thoracic segment lost if the deletions are parasegmental) and pT3 (lost if the deletions are segmental) are indistinguishable (Fig. 1C). ...
... deleted in pair-rule HSF embryos are segmental or parasegmental. Both phasings predict similar ventral cuticular phenotypes as the losses of, pT2 (posterior second thoracic segment lost if the deletions are parasegmental) and pT3 (lost if the deletions are segmental) are indistinguishable (Fig. 1C). ...
SURVEY AND SUMMARY H1 histones
... introns commonly observed in other protein-coding genes (85,86). Alternatively, somatic H1 genes contain a 30 stem-loop sequence allowing for rapid translation during DNA replication, while permitting tight regulation of gene expression after the conclusion of S phase (83,86,87). The expression patt ...
... introns commonly observed in other protein-coding genes (85,86). Alternatively, somatic H1 genes contain a 30 stem-loop sequence allowing for rapid translation during DNA replication, while permitting tight regulation of gene expression after the conclusion of S phase (83,86,87). The expression patt ...
Polycomb Group silencers collaborate with Notch pathway to cause
... HpaII will not cut at its recognition sequence if it contains a methylated cytosine (mCCGG), both MspI and HpaII digestion will be blocked if both cytosines are methylated (mCmCGG). ...
... HpaII will not cut at its recognition sequence if it contains a methylated cytosine (mCCGG), both MspI and HpaII digestion will be blocked if both cytosines are methylated (mCmCGG). ...
Gene Section PAX2 (Paired box gene 2) Atlas of Genetics and Cytogenetics
... PAX2 is overexpressed in a variety of cancers (see below). A detailed understanding of the mechanistic contribution mediated by PAX2 has yet to be established. However, inhibition of PAX2 expression in a number of cancer cell lines induces cell death, indicating a role for PAX2 in tumour cell surviv ...
... PAX2 is overexpressed in a variety of cancers (see below). A detailed understanding of the mechanistic contribution mediated by PAX2 has yet to be established. However, inhibition of PAX2 expression in a number of cancer cell lines induces cell death, indicating a role for PAX2 in tumour cell surviv ...
H4K20me1 Contributes to Downregulation of X
... The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in hermaphrodites but not in males, and some subunits fo ...
... The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in hermaphrodites but not in males, and some subunits fo ...
PDF - American Society of Mammalogists
... males and be passed only to other males (Just et al. 2002). The parental effects on mammalian X chromosomes are more subtle. The best known are those in which recessive X-linked phenotypes are disproportionately seen in males. This sex disparity in X chromosome phenotypes seems obvious given the sin ...
... males and be passed only to other males (Just et al. 2002). The parental effects on mammalian X chromosomes are more subtle. The best known are those in which recessive X-linked phenotypes are disproportionately seen in males. This sex disparity in X chromosome phenotypes seems obvious given the sin ...
The somatic-visceral subdivision of the embryonic mesoderm is
... a sna− genetic background, so that the only source of sna protein corresponds to the 2xPE-sna fusion gene (Fig. 2C). The distribution of sna mRNAs was visualized by in situ hybridization using a digoxigenin-labeled sna antisense RNA probe. As predicted from previous analyses of the PE promoter seque ...
... a sna− genetic background, so that the only source of sna protein corresponds to the 2xPE-sna fusion gene (Fig. 2C). The distribution of sna mRNAs was visualized by in situ hybridization using a digoxigenin-labeled sna antisense RNA probe. As predicted from previous analyses of the PE promoter seque ...
PDF
... The expression of snail in the hydroid Podocoryne, and the behaviour of cells containing it, have both interesting similarities and differences when compared to the situation in Acropora. During Podocoryne embryonic development snail mRNA, which is provided maternally, is present in all developmenta ...
... The expression of snail in the hydroid Podocoryne, and the behaviour of cells containing it, have both interesting similarities and differences when compared to the situation in Acropora. During Podocoryne embryonic development snail mRNA, which is provided maternally, is present in all developmenta ...
Sickle Cell Anemia - University of Washington Department of
... patients with sickle cell anemia, the γ globin mRNA levels in reticulocytes increase significantly. Perhaps butyrate or other chemicals that stimulate fetal hemoglobin production could be used to treat sickle cell anemia. • In 1983, a drug called hydroxyurea (HU) was first used on sickle cell patien ...
... patients with sickle cell anemia, the γ globin mRNA levels in reticulocytes increase significantly. Perhaps butyrate or other chemicals that stimulate fetal hemoglobin production could be used to treat sickle cell anemia. • In 1983, a drug called hydroxyurea (HU) was first used on sickle cell patien ...