Programme - biomed.cas.cz
... J. TEISINGER, V. VLACHOVÁ, Prague 2. PKA dependent effect of pregnenolone sulfate on NMDA receptors expressed in hippocampal neurons M. PETROVIC, H. CHODOUNSKÁ, M. SEDLÁČEK, L. VYKLICKÝ JR., Prague 3. The changes in phosphatidyl inositol 4,5 bisphosphate (PIP2) levels related to the TRPA1 channel ac ...
... J. TEISINGER, V. VLACHOVÁ, Prague 2. PKA dependent effect of pregnenolone sulfate on NMDA receptors expressed in hippocampal neurons M. PETROVIC, H. CHODOUNSKÁ, M. SEDLÁČEK, L. VYKLICKÝ JR., Prague 3. The changes in phosphatidyl inositol 4,5 bisphosphate (PIP2) levels related to the TRPA1 channel ac ...
Can we conquer pain?
... the functioning of central neurons. (a) Activity-dependent central sensitization. An immediate and relatively short-lasting increase in the excitability and responsiveness of pain transmission dorsal horn neurons, which is due to phosphorylation of ion channels and receptors and follows nociceptordr ...
... the functioning of central neurons. (a) Activity-dependent central sensitization. An immediate and relatively short-lasting increase in the excitability and responsiveness of pain transmission dorsal horn neurons, which is due to phosphorylation of ion channels and receptors and follows nociceptordr ...
Supplementary Information (doc 137K)
... Figure S1. The disruption of CREB activation observed in the CA1 region of dorsal hippocampus of Tg mice was specific in terms of brain region and CREB activation In Figures 1d and 1e, we showed that Tg mice had fewer pCREB+ neurons in the CA1 region of dorsal hippocampus than WT littermate mice acr ...
... Figure S1. The disruption of CREB activation observed in the CA1 region of dorsal hippocampus of Tg mice was specific in terms of brain region and CREB activation In Figures 1d and 1e, we showed that Tg mice had fewer pCREB+ neurons in the CA1 region of dorsal hippocampus than WT littermate mice acr ...
Biomarkery a mechanismy toxicity
... (effects at lower concentrations than expected from Kow, molecular mechanisms not fully clear) 3) Further, some compounds with reactive properties may directly - and nonspecifically (nonselectively) - react and modify any biological macromolecule (lipids, proteins, nucleic acids) (effects at even lo ...
... (effects at lower concentrations than expected from Kow, molecular mechanisms not fully clear) 3) Further, some compounds with reactive properties may directly - and nonspecifically (nonselectively) - react and modify any biological macromolecule (lipids, proteins, nucleic acids) (effects at even lo ...
Ischemic dysfunction in transgenic mice expressing - AJP
... replacement of these with alanine results in nearcomplete preservation in ATPase activity in response to PKC. Also, Takeishi et al. (27) have demonstrated that in vivo phosphorylation of TnI by PKC decreases myofilament responsiveness to calcium and contractility. In hearts, in which the PKC sites a ...
... replacement of these with alanine results in nearcomplete preservation in ATPase activity in response to PKC. Also, Takeishi et al. (27) have demonstrated that in vivo phosphorylation of TnI by PKC decreases myofilament responsiveness to calcium and contractility. In hearts, in which the PKC sites a ...
MAG, Nogo-A and NgR in Hippocampal Development and Regeneration TESIS DOCTORAL
... The question this thesis aims to address is, therefore, the role of myelin-associated inhibitors in the regeneration of cortical connections. The model we have used is the entorhino-hippocampal connection and the conceptual structure followed was i) characterizing the temporal expression of the prot ...
... The question this thesis aims to address is, therefore, the role of myelin-associated inhibitors in the regeneration of cortical connections. The model we have used is the entorhino-hippocampal connection and the conceptual structure followed was i) characterizing the temporal expression of the prot ...
Copyrighted Material
... neuron spans large distances but maintains less cytoplasmic volume and cell surface. Even so, the volume of the axon is much greater than the volume of the cell body. If one considers the lower motor neuron in humans, the cell body is located in the spinal cord and the axon extends to the site of in ...
... neuron spans large distances but maintains less cytoplasmic volume and cell surface. Even so, the volume of the axon is much greater than the volume of the cell body. If one considers the lower motor neuron in humans, the cell body is located in the spinal cord and the axon extends to the site of in ...
Mushroom body efferent neurons responsible for aversive olfactory
... the odor response of MB-V2 neurons was modified after conditioning. As the lateral horn has been implicated in innate responses to repellent odorants, we propose that MB-V2 neurons recruit the olfactory pathway involved in innate odor avoidance during memory retrieval. Different odors induce innate ...
... the odor response of MB-V2 neurons was modified after conditioning. As the lateral horn has been implicated in innate responses to repellent odorants, we propose that MB-V2 neurons recruit the olfactory pathway involved in innate odor avoidance during memory retrieval. Different odors induce innate ...
in systems and translational endocrinology
... Here, comprehensive evaluation of the progression of pregnancy in Clock/Clock mice is instructive of the periods during pregnancy that are most sensitive to circadian disruption. Clock/Clock mutant females have been shown to have difficulties at multiple stages of pregnancy. Despite a reduced or abs ...
... Here, comprehensive evaluation of the progression of pregnancy in Clock/Clock mice is instructive of the periods during pregnancy that are most sensitive to circadian disruption. Clock/Clock mutant females have been shown to have difficulties at multiple stages of pregnancy. Despite a reduced or abs ...
Brain-Derived Neurotrophic Factor Reduces Amyloidogenic
... patients with AD. Using screening approaches in primary neurons, we identified brain-derived neurotrophic factor (BDNF) as a major inducer of Sorla that activates receptor gene transcription through the ERK (extracellular regulated kinase) pathway. In line with a physiological role as regulator of S ...
... patients with AD. Using screening approaches in primary neurons, we identified brain-derived neurotrophic factor (BDNF) as a major inducer of Sorla that activates receptor gene transcription through the ERK (extracellular regulated kinase) pathway. In line with a physiological role as regulator of S ...
Full version (PDF file)
... There are noteworthy interareal differences in types of postsynaptic cells innervated by CR+ neurons. While pyramidal neurons (especially their dendrites) were found to represent the main target of CR+ axons in all examined layers in the human temporal neocortex (del Rio and DeFelipe 1997b), the CR+ ...
... There are noteworthy interareal differences in types of postsynaptic cells innervated by CR+ neurons. While pyramidal neurons (especially their dendrites) were found to represent the main target of CR+ axons in all examined layers in the human temporal neocortex (del Rio and DeFelipe 1997b), the CR+ ...
Combined therapy with PPARα agonist and l
... capable of activating cellular signaling pathways. 1,2Diacylglycerol (DAG) is one such lipid second messenger that activates protein kinase C (PKC) [15]. It has been considered that the DAG-PKC pathway is one of the important pathways mediating cardiac hypertrophy [16 – 18]. We have reported that di ...
... capable of activating cellular signaling pathways. 1,2Diacylglycerol (DAG) is one such lipid second messenger that activates protein kinase C (PKC) [15]. It has been considered that the DAG-PKC pathway is one of the important pathways mediating cardiac hypertrophy [16 – 18]. We have reported that di ...
- University of Alberta
... that can lead to severe obesity. The abnormal motivation to eat in PWS suggests a disruption in the hedonic feeding pathway, which is feeding based on reward as opposed to physiological need. Hedonic feeding is controlled by dopaminergic neurons in the ventral tegmental area (VTA) and other regions ...
... that can lead to severe obesity. The abnormal motivation to eat in PWS suggests a disruption in the hedonic feeding pathway, which is feeding based on reward as opposed to physiological need. Hedonic feeding is controlled by dopaminergic neurons in the ventral tegmental area (VTA) and other regions ...
Medical Gross Anatomy - University of Michigan
... homeostasis via two opposing divisions: the sympathetic division and the parasympathetic division. Both the sympathetic and parasympathetic systems innervate most of the body's organs and act in opposition to one another to maintain normal physiology, including blood pressure, blood oxygen levels, a ...
... homeostasis via two opposing divisions: the sympathetic division and the parasympathetic division. Both the sympathetic and parasympathetic systems innervate most of the body's organs and act in opposition to one another to maintain normal physiology, including blood pressure, blood oxygen levels, a ...
Gene Section GHRL (ghrelin/obestatin prepropeptide) Atlas of Genetics and Cytogenetics
... As the endogenous ligand of the growth hormone secretagogues (GHS) receptor, Ghrelin/MTLRP is involved in the pulsatile secretion of Growth hormone. In addition to this role Ghrelin/MTLRP is in the regulation of feeding. In rodent In contrast to leptin, Ghrelin/MTLRP promotes food intake and obesity ...
... As the endogenous ligand of the growth hormone secretagogues (GHS) receptor, Ghrelin/MTLRP is involved in the pulsatile secretion of Growth hormone. In addition to this role Ghrelin/MTLRP is in the regulation of feeding. In rodent In contrast to leptin, Ghrelin/MTLRP promotes food intake and obesity ...
Estradiol, Substance P, and the PI3K-Akt
... The pain system is exceedingly complex. Its features include plasticity in the primary afferents, dorsal horn, and brain; pain inhibition systems; descending modulation from the brain to the dorsal horn; changes in extracellular signaling molecules and inflammatory mediators; changes in membrane rec ...
... The pain system is exceedingly complex. Its features include plasticity in the primary afferents, dorsal horn, and brain; pain inhibition systems; descending modulation from the brain to the dorsal horn; changes in extracellular signaling molecules and inflammatory mediators; changes in membrane rec ...
Voluntary Nicotine Consumption Triggers Potentiation of Cortical Excitatory Drives to Midbrain
... excitation to DA neurons of the VTA (Massi et al., 2008). Are these cortical inputs involved in active responding? The pharmacological target of nicotine, the main addictive component of tobacco, for the control of VTA DA neuron activity is now well identified (Mameli-Engvall et al., 2006). It is kn ...
... excitation to DA neurons of the VTA (Massi et al., 2008). Are these cortical inputs involved in active responding? The pharmacological target of nicotine, the main addictive component of tobacco, for the control of VTA DA neuron activity is now well identified (Mameli-Engvall et al., 2006). It is kn ...
Amelioration of Delayed Neuronal Death in the Hippocampus by
... and 2, eventhoughthe cell somawas still present.After 1 week,all the pyramidal cellstogetherwith dendrites disappeared without NGF treatment. Treatment with NGF preventedthe early destructionof dendritic structures. ...
... and 2, eventhoughthe cell somawas still present.After 1 week,all the pyramidal cellstogetherwith dendrites disappeared without NGF treatment. Treatment with NGF preventedthe early destructionof dendritic structures. ...
Wang et al 2photon calcium imaging of odor in fly brain cell 2003
... concentrations and glomeruli respond to multiple odors of widely different structures. The threshold of activation differs for different glomeruli so that the number of activated glomeruli increases with odor concentration. The patterns of activity are insular such that neighboring glomeruli do not ...
... concentrations and glomeruli respond to multiple odors of widely different structures. The threshold of activation differs for different glomeruli so that the number of activated glomeruli increases with odor concentration. The patterns of activity are insular such that neighboring glomeruli do not ...
Dopamine: the rewarding years
... their pharmacology and coupling to adenylyl cyclase (Kebabian & Calne, 1979). This receptor remains a key target for antipsychotic drugs, although it is also known to be linked to various adverse side effects associated with such drugs (see later). It was not until the early 1980s that the dopamine ...
... their pharmacology and coupling to adenylyl cyclase (Kebabian & Calne, 1979). This receptor remains a key target for antipsychotic drugs, although it is also known to be linked to various adverse side effects associated with such drugs (see later). It was not until the early 1980s that the dopamine ...
Presumed Apoptosis and Reduced Arcuate Nucleus
... frozen tissue using an ApopTag kit (Intergen, Purchase, NY). This procedure enzymatically labels the DNA 3-OH strand breaks on both single- and doublestranded DNA with unlabeled and digoxigenin-labeled nucleotides by terminal deoxynucleotidyl transferase (18). The reaction was carried out on 5-µm f ...
... frozen tissue using an ApopTag kit (Intergen, Purchase, NY). This procedure enzymatically labels the DNA 3-OH strand breaks on both single- and doublestranded DNA with unlabeled and digoxigenin-labeled nucleotides by terminal deoxynucleotidyl transferase (18). The reaction was carried out on 5-µm f ...
Layer II/III of the Prefrontal Cortex: Inhibition by the Serotonin
... Subsequent exposure to social isolation in adulthood resulted in the almost-complete elimination of 5-HT1A currents in layer II/III neurons suggesting an interaction between early life events and adult experiences. These data represent the first examination of functional 5-HT1A receptors in layer II ...
... Subsequent exposure to social isolation in adulthood resulted in the almost-complete elimination of 5-HT1A currents in layer II/III neurons suggesting an interaction between early life events and adult experiences. These data represent the first examination of functional 5-HT1A receptors in layer II ...
Aerobic Glycolysis in the Frontal Cortex Correlates with Memory
... Magistretti and Allaman, 2015). Aerobic glycolysis can be described as the reliance on glycolysis, even when oxygen is not rate-limiting, with the concomitant production of lactate as a by-product (Lunt and Vander Heiden, 2011). Emerging evidence suggests that lactate production and transport betwee ...
... Magistretti and Allaman, 2015). Aerobic glycolysis can be described as the reliance on glycolysis, even when oxygen is not rate-limiting, with the concomitant production of lactate as a by-product (Lunt and Vander Heiden, 2011). Emerging evidence suggests that lactate production and transport betwee ...
Altered fear learning across development in both mouse and human
... PSYCHOLOGICAL AND COGNITIVE SCIENCES ...
... PSYCHOLOGICAL AND COGNITIVE SCIENCES ...
Role of the Preoptic-Anterior Hypothalamus in
... q 2000 by the Infectious Diseases Society of America. All rights reserved. 1058-4838/2000/3104S5-0003$03.00 ...
... q 2000 by the Infectious Diseases Society of America. All rights reserved. 1058-4838/2000/3104S5-0003$03.00 ...