Distinct Functions of 3 and V Integrin Receptors
... from each other, whereas those from wild-type brains adhered to each other freely. In some cortical imprint neuronal migration assays, dense cohorts of neurons were found to migrate on radial glial fibers (Figure 5G). The inhibition of a3 integrins in these assays caused neurons not only to stop the ...
... from each other, whereas those from wild-type brains adhered to each other freely. In some cortical imprint neuronal migration assays, dense cohorts of neurons were found to migrate on radial glial fibers (Figure 5G). The inhibition of a3 integrins in these assays caused neurons not only to stop the ...
Odorant Category Profile Selectivity of Olfactory Cortex Neurons
... used for single category stimulation without a flow rate change. These odorants were obtained from Sigma (St. Louis, MO), Tokyo Chemical Industry (Tokyo, Japan), or Kanto Chemical (Tokyo, Japan). Data analysis. An analysis of the spike responses was performed off-line using the Spike2 software progr ...
... used for single category stimulation without a flow rate change. These odorants were obtained from Sigma (St. Louis, MO), Tokyo Chemical Industry (Tokyo, Japan), or Kanto Chemical (Tokyo, Japan). Data analysis. An analysis of the spike responses was performed off-line using the Spike2 software progr ...
The Impact of Prior Experience With Cross-Modal
... multimodal stimuli. If cells in the intSC do not necessarily have to do MI, neural activity in intSC evoked by multimodal stimulation may be greater in animals that have prior multisensory experience than those that do not. The second goal of this study was to investigate this possibility. This stud ...
... multimodal stimuli. If cells in the intSC do not necessarily have to do MI, neural activity in intSC evoked by multimodal stimulation may be greater in animals that have prior multisensory experience than those that do not. The second goal of this study was to investigate this possibility. This stud ...
Integrative actions of the reticular formation The reticular activating
... Young, George A., "Integrative actions of the reticular formation The reticular activating system, autonomic mechanisms and visceral ...
... Young, George A., "Integrative actions of the reticular formation The reticular activating system, autonomic mechanisms and visceral ...
Neurons of human nucleus accumbens
... which we found in human nucleus accumbens correspond to the spiny I type of neurons in monkey striatum described by Di Figlia et al. 12. Our fusiform neuron (type I) could correspond to the spiny I neurons with flattened soma described by some authors 12. However, human striate spiny neurons with si ...
... which we found in human nucleus accumbens correspond to the spiny I type of neurons in monkey striatum described by Di Figlia et al. 12. Our fusiform neuron (type I) could correspond to the spiny I neurons with flattened soma described by some authors 12. However, human striate spiny neurons with si ...
Control of Gonadotropin Secretion by Follicle
... between the biotin moiety and one amino acid of the peptide. Three biotinylated derivatives of lGnRH-III were tested for bioactivity. The peptide derivative biotinylated on Lys8 with two spacer arms of aminocaproic acid (Bxx-Lys8lGnRH-III) had selective FSH-releasing activity at a dose of 108 M on ...
... between the biotin moiety and one amino acid of the peptide. Three biotinylated derivatives of lGnRH-III were tested for bioactivity. The peptide derivative biotinylated on Lys8 with two spacer arms of aminocaproic acid (Bxx-Lys8lGnRH-III) had selective FSH-releasing activity at a dose of 108 M on ...
2906_lect8
... by which, after long-term exposure to an odorant, one is no longer able to detect that odorant or has very diminished detection ability Example: Going out of town, coming back and noticing how your house smells ...
... by which, after long-term exposure to an odorant, one is no longer able to detect that odorant or has very diminished detection ability Example: Going out of town, coming back and noticing how your house smells ...
Properties of Single Neurons Responsive to Light Mechanical
... singlemorphologically identifiable mechanoreceptortype), predictable from knowledge of the properties of primary mechanoreceptive afferents (B. H. Pubols and Pubols, 1983). These 136 neurons, whose RFs lay entirely on glabrous skin, are characterized in Table 1A. The remaining 10 (< 7% of total samp ...
... singlemorphologically identifiable mechanoreceptortype), predictable from knowledge of the properties of primary mechanoreceptive afferents (B. H. Pubols and Pubols, 1983). These 136 neurons, whose RFs lay entirely on glabrous skin, are characterized in Table 1A. The remaining 10 (< 7% of total samp ...
Fibroblast Growth Factor Receptor Inhibitors
... (Fig. 3). Recent studies by Christofk et al. [47] have found that PKM2 is crucial for aerobic glycolysis and provides a growth advantage to tumours. They also demonstrated that the pyruvate kinase M2 isoform (PKM2) enzymatic activity is inhibited by direct phosphorylation at tyrosine residue 105 (Y1 ...
... (Fig. 3). Recent studies by Christofk et al. [47] have found that PKM2 is crucial for aerobic glycolysis and provides a growth advantage to tumours. They also demonstrated that the pyruvate kinase M2 isoform (PKM2) enzymatic activity is inhibited by direct phosphorylation at tyrosine residue 105 (Y1 ...
Functional Synaptic Contacts by Intranuclear
... relay cell axons in the ventrobasal complex of cats after intracelsensitivity to various neuromodulators that differ significantly lular filling of these cells with horseradish peroxidase has failed to from analogous properties in intralaminar interneurons do so (Yen and Jones, 1983; Yen et al., 198 ...
... relay cell axons in the ventrobasal complex of cats after intracelsensitivity to various neuromodulators that differ significantly lular filling of these cells with horseradish peroxidase has failed to from analogous properties in intralaminar interneurons do so (Yen and Jones, 1983; Yen et al., 198 ...
Full text
... species supported the hypothesis that NPY might be involved in the regulation of GnRH secretion. In the present study, we have demonstrated that the population of NPY-ir neurons in the periventricular nucleus does not change during the two phases of the oestrous cycle. This area of the hypothalamus ...
... species supported the hypothesis that NPY might be involved in the regulation of GnRH secretion. In the present study, we have demonstrated that the population of NPY-ir neurons in the periventricular nucleus does not change during the two phases of the oestrous cycle. This area of the hypothalamus ...
Print
... processes are also of great interest in understanding mechanisms of disease and for the development of effective therapies. Thus inhibitors of ACE are widely used to treat hypertension and congestive heart failure, and antagonists of PARs are being developed to treat thrombotic and inflammatory dise ...
... processes are also of great interest in understanding mechanisms of disease and for the development of effective therapies. Thus inhibitors of ACE are widely used to treat hypertension and congestive heart failure, and antagonists of PARs are being developed to treat thrombotic and inflammatory dise ...
How Inhibition Shapes Cortical Activity
... rectifying K+ (GIRK) channels (Lüscher et al., 1997). It has been suggested that synaptically released GABA from a large number of coactive interneurons must be pooled or accumulated to activate GABAB receptors (Isaacson et al., 1993; Scanziani, 2000). Postsynaptic GABAB receptors also inhibit volt ...
... rectifying K+ (GIRK) channels (Lüscher et al., 1997). It has been suggested that synaptically released GABA from a large number of coactive interneurons must be pooled or accumulated to activate GABAB receptors (Isaacson et al., 1993; Scanziani, 2000). Postsynaptic GABAB receptors also inhibit volt ...
Chemosensory Systems
... cells have distinct shapes, biochemical features and likely distinct functions. 2. Taste buds occur on the tongue: in fungiform papillae on the dorsal anterior 2/3rds, in foliate papillae on lateral edges and in circumvallate papillae on dorsal posterior tongue; and in palatal and oral pharyngeal mu ...
... cells have distinct shapes, biochemical features and likely distinct functions. 2. Taste buds occur on the tongue: in fungiform papillae on the dorsal anterior 2/3rds, in foliate papillae on lateral edges and in circumvallate papillae on dorsal posterior tongue; and in palatal and oral pharyngeal mu ...
Why Are Olfactory Systems of Different Animals So Similar?
... to be an excellent model for anatomical and electrophysiological studies because of its large brain and large, accessible antennae; in contrast, the fruit fly Drosophila melanogaster is more suitable for molecular and genetic studies, but because of its small size fewer anatomical and electrophysiol ...
... to be an excellent model for anatomical and electrophysiological studies because of its large brain and large, accessible antennae; in contrast, the fruit fly Drosophila melanogaster is more suitable for molecular and genetic studies, but because of its small size fewer anatomical and electrophysiol ...
The Molecular Biology of Memory Storage: A Dialog
... Thus, the unique functions of the hippocampus had to arise not so much from the intrinsic properties of pyramidal neurons but from the pattern of functional interconnections of these cells, and how those interconnections are affected by learning. To tackle that problem we needed to know how sensory ...
... Thus, the unique functions of the hippocampus had to arise not so much from the intrinsic properties of pyramidal neurons but from the pattern of functional interconnections of these cells, and how those interconnections are affected by learning. To tackle that problem we needed to know how sensory ...
Cortico–basal ganglia circuit mechanism for a decision threshold in
... mathematical models in which sensory information is integrated stochastically over time, resulting in a random walk of an abstract variable toward a preset decision threshold. A decision is made when the random walker reaches the threshold1–4. Recently, neurophysiological studies on nonhuman primate ...
... mathematical models in which sensory information is integrated stochastically over time, resulting in a random walk of an abstract variable toward a preset decision threshold. A decision is made when the random walker reaches the threshold1–4. Recently, neurophysiological studies on nonhuman primate ...
Negatively-Correlated Firing - Department of Computer Science
... interneurons are very common in the neocortex, and lateral inhibition has been shown to play an important role in sharpening the distinctions between similar inputs, where such inputs would otherwise invoke nearly the same response in neurons with only slightly different response properties. However ...
... interneurons are very common in the neocortex, and lateral inhibition has been shown to play an important role in sharpening the distinctions between similar inputs, where such inputs would otherwise invoke nearly the same response in neurons with only slightly different response properties. However ...
Neurons, Brain Chemistry, and Neurotransmission
... Figure 2.5: Schematic diagram of a synapse. In response to an electrical impulse, neurotransmitter molecules released from the presynaptic axon terminal bind to the specific receptors for that neurotransmitter on the postsynaptic neuron. After binding to the receptor, the neurotransmitter molecules ...
... Figure 2.5: Schematic diagram of a synapse. In response to an electrical impulse, neurotransmitter molecules released from the presynaptic axon terminal bind to the specific receptors for that neurotransmitter on the postsynaptic neuron. After binding to the receptor, the neurotransmitter molecules ...
Interplay of environmental signals and progenitor diversity on fate
... the two most abundant classes of cortical interneurons with non-overlapping molecular identities and relatively large cell bodies (>20µm; DeFelipe, 1993, 1997; Kawaguchi and Kondo, 2002). GABAergic interneurons expressing PV make up ∼40% of all cortical interneurons of which basket and chandelier ce ...
... the two most abundant classes of cortical interneurons with non-overlapping molecular identities and relatively large cell bodies (>20µm; DeFelipe, 1993, 1997; Kawaguchi and Kondo, 2002). GABAergic interneurons expressing PV make up ∼40% of all cortical interneurons of which basket and chandelier ce ...
Distribution of Androgen and Estrogen Receptor mRNA in the Brain
... Incubation temperature during embryonic development determines gonadal sex in the leopard gecko as it does in some other lizards, many turtles, and all crocodilians (Ewert et al., 1994; Lang and Andrews, 1994; Viets et al., 1994). In the leopard gecko, low temperatures (26°C) and high temperatures ( ...
... Incubation temperature during embryonic development determines gonadal sex in the leopard gecko as it does in some other lizards, many turtles, and all crocodilians (Ewert et al., 1994; Lang and Andrews, 1994; Viets et al., 1994). In the leopard gecko, low temperatures (26°C) and high temperatures ( ...
Comprehensive imaging of cortical networks
... contrast and signal-to-noise ratio compared to wide-field microscopy, particularly when imaging in scattering media [51]. The principles of 2-photon excitation microscopy demand that individual excitation volumes (on the order of 1 mm3) are sampled sequentially. The sampling rate is ultimately limit ...
... contrast and signal-to-noise ratio compared to wide-field microscopy, particularly when imaging in scattering media [51]. The principles of 2-photon excitation microscopy demand that individual excitation volumes (on the order of 1 mm3) are sampled sequentially. The sampling rate is ultimately limit ...
Reith RM, McKenna J, Wu H, Hashmi SS, Cho SH, Dash PK, Gambello MJ. Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex. Neurobiology of Disease. 2013 Mar;51:93-103.
... (Cappon, 1953; Rutter, 1978; Wing, 1981). The incidence of ASD is about 1 in every 110 births, with a higher occurrence in boys than in girls (4.5:1) (Prevention, 2006), and an estimated heritability of about 90% based upon monozygotic twin studies (Folstein and Rutter, 1977; Muhle et al., 2004). Tr ...
... (Cappon, 1953; Rutter, 1978; Wing, 1981). The incidence of ASD is about 1 in every 110 births, with a higher occurrence in boys than in girls (4.5:1) (Prevention, 2006), and an estimated heritability of about 90% based upon monozygotic twin studies (Folstein and Rutter, 1977; Muhle et al., 2004). Tr ...