The Janus face of immunity : how anti-tumor
... Christina Gebauer. The Janus face of immunity : how anti-tumor immunity leads to autoimmunity in paraneoplastic neurological diseases. Immunology. Université Paul Sabatier - Toulouse III, 2016. English..
...
... Christina Gebauer. The Janus face of immunity : how anti-tumor immunity leads to autoimmunity in paraneoplastic neurological diseases. Immunology. Université Paul Sabatier - Toulouse III, 2016. English.
PDF - The Journal of Experimental Medicine
... patients who responded to anti–PD-1 therapy and then relapsed many months to years later while on continued therapy. Comparison of baseline and relapsed tumors showed in two cases that JAK1 or JAK2 alleles had been mutated with a loss of function truncation event, whereas the other wild-type allele ...
... patients who responded to anti–PD-1 therapy and then relapsed many months to years later while on continued therapy. Comparison of baseline and relapsed tumors showed in two cases that JAK1 or JAK2 alleles had been mutated with a loss of function truncation event, whereas the other wild-type allele ...
Characterization of extracellular and surface bound adherence
... formation found in S.aureus infected wounds. Eap has the ability to bind most of all known matrix proteins. It also serves several functions that interfere with the host immune system. This could be one explanation to the poorly functioning immunologic memory found after an S. aureus infection. The ...
... formation found in S.aureus infected wounds. Eap has the ability to bind most of all known matrix proteins. It also serves several functions that interfere with the host immune system. This could be one explanation to the poorly functioning immunologic memory found after an S. aureus infection. The ...
TLR3 Signaling in Macrophages Is Indispensable for the
... (TCR) and share a number of cell surface markers in common with NK cells. iNKT cells recognize glycolipid antigens presented by the invariant MHC class I-like molecule CD1d, which is expressed mainly on dendritic cells (DCs) and macrophages. Following lipid antigen stimulation, iNKT cells express CD ...
... (TCR) and share a number of cell surface markers in common with NK cells. iNKT cells recognize glycolipid antigens presented by the invariant MHC class I-like molecule CD1d, which is expressed mainly on dendritic cells (DCs) and macrophages. Following lipid antigen stimulation, iNKT cells express CD ...
HIV persistence in the testis?
... SIV-specific CD8 T cells were detected in the testis However cytokine production in response to mitogens was inhibited by SIV infection ...
... SIV-specific CD8 T cells were detected in the testis However cytokine production in response to mitogens was inhibited by SIV infection ...
Medical Veterinary Entomology
... the secretory glands in the subepithelial region. Increased numbers of T lymphocytes and localization in the chorion represent clear evidence that most antigen recognition occurs in antigenpresenting cells in the sinus cavities and indicates that adaptive immunity is being developed. In addition, th ...
... the secretory glands in the subepithelial region. Increased numbers of T lymphocytes and localization in the chorion represent clear evidence that most antigen recognition occurs in antigenpresenting cells in the sinus cavities and indicates that adaptive immunity is being developed. In addition, th ...
Chapter 11 INTERLEUKIN-2 IN THE TREATMENT OF` RENAL CELL
... Although the initial trials suggesting a benefit from IL-2 explored its use in combination with LAK cells, a few trials at the NCI suggested that IL-2 alone (without LAK cells) might have activity against cancers in experimental and clinical settings.31Randomized trials33'34 were therefore performed ...
... Although the initial trials suggesting a benefit from IL-2 explored its use in combination with LAK cells, a few trials at the NCI suggested that IL-2 alone (without LAK cells) might have activity against cancers in experimental and clinical settings.31Randomized trials33'34 were therefore performed ...
Study of Alternative Functions of the Mitochondrial Protein Bak
... proliferation, survival, and metabolism. Transformed cells can grow virtually without constraint and can evade apoptotic signals (Hamanaka & Chandel, 2010). Proapoptotic proteins Bak/Bax are crucial to apoptosis, but when these proteins are deleted, severe development defects arise (Leshchiner et al ...
... proliferation, survival, and metabolism. Transformed cells can grow virtually without constraint and can evade apoptotic signals (Hamanaka & Chandel, 2010). Proapoptotic proteins Bak/Bax are crucial to apoptosis, but when these proteins are deleted, severe development defects arise (Leshchiner et al ...
Generation of Monoclonal Antibodies to Cryptic Collagen Sites by
... to cryptic sites within collagen is associated with the immunodominant epitopes found within its triple helical and noncollagenous domains. These major structural epitopes likely dominate the immune response. In fact, the majority of MAbs developed to date are directed to epitopes normally exposed w ...
... to cryptic sites within collagen is associated with the immunodominant epitopes found within its triple helical and noncollagenous domains. These major structural epitopes likely dominate the immune response. In fact, the majority of MAbs developed to date are directed to epitopes normally exposed w ...
Cutaneous Lymphoma at Injection Sites
... previous vaccine injection by the referring veterinarian and presented either as a single nodule or localized disease. Of the 30 cases not included, 24 developed at noninjection cutaneous sites, while in 6 cases, site and history were not retrieved; only one of these had microscopic features resembl ...
... previous vaccine injection by the referring veterinarian and presented either as a single nodule or localized disease. Of the 30 cases not included, 24 developed at noninjection cutaneous sites, while in 6 cases, site and history were not retrieved; only one of these had microscopic features resembl ...
The Immune System Drugs in Fish: Immune Function, Immunoassay
... transduction of immunoglobulin from the serum (Shoemarker et al., 2001). Mucous or goblet cells secrete mucus, which has at least three different types of defensive roles: (1) Mucus interrupts establishment of microbes by being continually sloughed off. (2) If establishment is accomplished, mucus ac ...
... transduction of immunoglobulin from the serum (Shoemarker et al., 2001). Mucous or goblet cells secrete mucus, which has at least three different types of defensive roles: (1) Mucus interrupts establishment of microbes by being continually sloughed off. (2) If establishment is accomplished, mucus ac ...
Skeletal System
... – It functions strictly in T lymphocyte maturation and thus is the only lymphoid organ that does not directly fight antigens – The stroma of the thymus consists of starshaped epithelial cells rather than reticular fibers. These thymocytes secrete the hormones that stimulate the lymphocytes to become ...
... – It functions strictly in T lymphocyte maturation and thus is the only lymphoid organ that does not directly fight antigens – The stroma of the thymus consists of starshaped epithelial cells rather than reticular fibers. These thymocytes secrete the hormones that stimulate the lymphocytes to become ...
Ângela França and Nuno Cerca* Plasma is the main regulator of S
... tolerance to antibiotics and host immune response being, consequently, commonly associated with the development of chronic and recalcitrant infections (Costerton 1999). S. epidermidis, a skin- and mucosae-colonizing bacterium, has a remarkable ability to form biofilms on the surface of indwelling me ...
... tolerance to antibiotics and host immune response being, consequently, commonly associated with the development of chronic and recalcitrant infections (Costerton 1999). S. epidermidis, a skin- and mucosae-colonizing bacterium, has a remarkable ability to form biofilms on the surface of indwelling me ...
Sleeping sickness and the central nervous system* V.W. PENTREATH P.J. BAUGH
... already summarized above, include perivascular cuffing with B-cells (mainly plasma cells) , morular cells, activated T -cells, macrophages and reactive astrocytes and microglia. In the areas of reduced bloodbrain barrier which are selectively penetrated by trypanosomes, there may be induction of maj ...
... already summarized above, include perivascular cuffing with B-cells (mainly plasma cells) , morular cells, activated T -cells, macrophages and reactive astrocytes and microglia. In the areas of reduced bloodbrain barrier which are selectively penetrated by trypanosomes, there may be induction of maj ...
Licentiate thesis from the Department of Immunology,
... strains. Multiplicity of infection (MOI) is known as an indicator of immune status. However, whether high or low MOI are good or bad for the development of immunity to malaria is still not clear. Our second study aimed to examine the MOI in asymptomatic children aged 2-10 years and to relate it to t ...
... strains. Multiplicity of infection (MOI) is known as an indicator of immune status. However, whether high or low MOI are good or bad for the development of immunity to malaria is still not clear. Our second study aimed to examine the MOI in asymptomatic children aged 2-10 years and to relate it to t ...
A Cyclin A-Protein Kinase Complex Possesses
... appear to play major roles in regulating the progression of cells through Gl (see Marshall, 1991). In addition, the analysis of proteins such as adenovirus ElA has provided insights into the mechanism by which proteins such as the retinoblastoma gene product function to control cell proliferation. T ...
... appear to play major roles in regulating the progression of cells through Gl (see Marshall, 1991). In addition, the analysis of proteins such as adenovirus ElA has provided insights into the mechanism by which proteins such as the retinoblastoma gene product function to control cell proliferation. T ...
Localization of Receptors for Vasoactive Intestinal
... receptors, and SP receptors, are expressed by human lymphoid organs in different, topographically distinct structures. The CCK receptors do not appear to play a major role in the tissues tested in this study. In lymph nodes, the localization of SS receptors correlated well with that of germinal cent ...
... receptors, and SP receptors, are expressed by human lymphoid organs in different, topographically distinct structures. The CCK receptors do not appear to play a major role in the tissues tested in this study. In lymph nodes, the localization of SS receptors correlated well with that of germinal cent ...
Persistent accumulation of interferon-gamma- producing CD8(+)CD56(+) T cells in blood from
... prominent components of human atherosclerotic lesions2-3 and also, blood samples from patients with coronary artery disease (CAD), in particular acute coronary syndromes (ACS), show signs of T cell activation4-6. While much attention has been focused on the role of CD4+ T cells, the CD8+ T cell comp ...
... prominent components of human atherosclerotic lesions2-3 and also, blood samples from patients with coronary artery disease (CAD), in particular acute coronary syndromes (ACS), show signs of T cell activation4-6. While much attention has been focused on the role of CD4+ T cells, the CD8+ T cell comp ...
Proliferation T Cell + Nonredundantly Stimulates CD8
... IL-2 can also stimulate conventional T cells (6). All of these cytokines bind to receptors that contain cytokine receptor common ␥-chain (␥c)3 (7) and activate Stat5 transcription factors that are essential for their T cell stimulatory effects (8). In contrast, although IL-4 binds to a constitutivel ...
... IL-2 can also stimulate conventional T cells (6). All of these cytokines bind to receptors that contain cytokine receptor common ␥-chain (␥c)3 (7) and activate Stat5 transcription factors that are essential for their T cell stimulatory effects (8). In contrast, although IL-4 binds to a constitutivel ...
University of Groningen Plasticity of airway smooth muscle
... bronchoconstriction, mucus secretion and pain perception [1]. Evidence exists to assume the involvement of bradykinin in asthma, since asthmatics display exaggerated bronchoconstrictor responses to bradykinin when compared to healthy controls [2]. Moreover, kallikrein levels are increased in the bro ...
... bronchoconstriction, mucus secretion and pain perception [1]. Evidence exists to assume the involvement of bradykinin in asthma, since asthmatics display exaggerated bronchoconstrictor responses to bradykinin when compared to healthy controls [2]. Moreover, kallikrein levels are increased in the bro ...
Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance
... a decisive factor in Helios expression on iTreg cells, rather than in nTreg or iTreg cell origin (30). In this case, the authors used T cells from TCR–transgenic RAG-deficient mice (which lack nTreg cells) and differentiated them to iTreg cells in vitro using TGF-β and IL-2 and two different activati ...
... a decisive factor in Helios expression on iTreg cells, rather than in nTreg or iTreg cell origin (30). In this case, the authors used T cells from TCR–transgenic RAG-deficient mice (which lack nTreg cells) and differentiated them to iTreg cells in vitro using TGF-β and IL-2 and two different activati ...
Learning objectives
... 4. Define phagocytosis. Name four types of phagocytic leukocytes. 5. Explain how phagocytic leukocytes recognize microbes. 6. Describe the roles of antimicrobial proteins in innate immunity. 7. Explain how interferons limit cell-to-cell spread of viruses. 8. Describe the inflammation response, inclu ...
... 4. Define phagocytosis. Name four types of phagocytic leukocytes. 5. Explain how phagocytic leukocytes recognize microbes. 6. Describe the roles of antimicrobial proteins in innate immunity. 7. Explain how interferons limit cell-to-cell spread of viruses. 8. Describe the inflammation response, inclu ...
State-of-the-art review about basophil research in immunology and
... in promoting allergic inflammation and in inducing the onset of chronic allergy has been also suggested2,4. Basophils are indeed important IL-4-providing inducers of Th28,13. Dendritic cells play a central role in the initiation of Th1- and Th17-mediated immunity and the differentiation of these cel ...
... in promoting allergic inflammation and in inducing the onset of chronic allergy has been also suggested2,4. Basophils are indeed important IL-4-providing inducers of Th28,13. Dendritic cells play a central role in the initiation of Th1- and Th17-mediated immunity and the differentiation of these cel ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.