Examples of Supervisors and Research Projects (Wellcome)
... The role of the erythrocyte cytoskeleton and membrane in malaria parasite invasion of the red blood cell Host factors involved in retroviral DNA integration Characterisation of plasmodium vivax transmission in the Amazon Age related changes to innate anti-viral immunity in the lung Exploration of he ...
... The role of the erythrocyte cytoskeleton and membrane in malaria parasite invasion of the red blood cell Host factors involved in retroviral DNA integration Characterisation of plasmodium vivax transmission in the Amazon Age related changes to innate anti-viral immunity in the lung Exploration of he ...
Capacity of Epstein–Barr virus to infect monocytes and inhibit their
... (Hoffman et al., 1980), specific for the EBV gp350/220 glycoprotein, and CL59 (Molesworth et al., 2000), specific for gH, were purified from culture supernatants of the corresponding hybridoma cell lines. The mAb 5B2, which is specific for gB, was purchased from Virusys. FACS analysis of virus bound ...
... (Hoffman et al., 1980), specific for the EBV gp350/220 glycoprotein, and CL59 (Molesworth et al., 2000), specific for gH, were purified from culture supernatants of the corresponding hybridoma cell lines. The mAb 5B2, which is specific for gB, was purchased from Virusys. FACS analysis of virus bound ...
Resveratrol decreases miR-155 levels by upregulating miR
... cells, suggesting that miR-663 normally works to impair any sudden surge of AP-1 activity or JunB levels in resting cells (Figure 2A and 2B). Finally, luciferase assays using constructs containing JunB 3’-untranslated region (UTR) with wild type or mutated miR-663 target sites provided strong eviden ...
... cells, suggesting that miR-663 normally works to impair any sudden surge of AP-1 activity or JunB levels in resting cells (Figure 2A and 2B). Finally, luciferase assays using constructs containing JunB 3’-untranslated region (UTR) with wild type or mutated miR-663 target sites provided strong eviden ...
Reactive And Enteropathic Arthritis
... Human Leukocyte Antigen-B27 and Host Immune Responses The strong association between HLA-B27 and SpA has indirectly implicated microbial antigen-specific, MHC class I-restricted CD8+ CTLs as having a role in the pathogenesis of these diseases. CD8+ T cells in synovial fluid can express a heterogeneo ...
... Human Leukocyte Antigen-B27 and Host Immune Responses The strong association between HLA-B27 and SpA has indirectly implicated microbial antigen-specific, MHC class I-restricted CD8+ CTLs as having a role in the pathogenesis of these diseases. CD8+ T cells in synovial fluid can express a heterogeneo ...
Reprint - Immune Tolerance Network
... surveillance toward tumor antigens and microbial pathogens. This is because immunosuppressive drugs target common pathways of immune activation, such as calcium signaling (cyclosporin A, FK506), purine biosynthesis (Mycophenolate), and T-cell costimulation (CTLA4Ig). Other immunosuppressive drugs su ...
... surveillance toward tumor antigens and microbial pathogens. This is because immunosuppressive drugs target common pathways of immune activation, such as calcium signaling (cyclosporin A, FK506), purine biosynthesis (Mycophenolate), and T-cell costimulation (CTLA4Ig). Other immunosuppressive drugs su ...
T Lymphocyte Responses + Despite Augmenting Antigen
... T cells play a critical role in cellular immunity against intracellular bacterial pathogens, such as Listeria monocytogenes and Mycobacterium tuberculosis (8). Effector CD4⫹ T cells act as Th cells during Listeria infection by the production of Th1-type cytokines, such as IFN-␥, which activate macro ...
... T cells play a critical role in cellular immunity against intracellular bacterial pathogens, such as Listeria monocytogenes and Mycobacterium tuberculosis (8). Effector CD4⫹ T cells act as Th cells during Listeria infection by the production of Th1-type cytokines, such as IFN-␥, which activate macro ...
Thèse de doctorat
... Tumors grow within a complex microenvironment composed of immune cells, fibroblasts, endothelial cells and other non-malignant cells. The study of the composition of tumor microenvironments has led to classifications with prognostic and theranostic values, as well as the discovery of treatments modu ...
... Tumors grow within a complex microenvironment composed of immune cells, fibroblasts, endothelial cells and other non-malignant cells. The study of the composition of tumor microenvironments has led to classifications with prognostic and theranostic values, as well as the discovery of treatments modu ...
Biology 103 Lecture and Biology 103A Lab Objectives
... 1. List the main structures of the plasma membrane. Relate each to the fluid mosaic model of membrane structure. Include: phopholipids, proteins, glycolipids, glycoproteins, and cholesterol (animal cells only). 2. Explain why the plasma membrane is called a differentially permeable or selectively pe ...
... 1. List the main structures of the plasma membrane. Relate each to the fluid mosaic model of membrane structure. Include: phopholipids, proteins, glycolipids, glycoproteins, and cholesterol (animal cells only). 2. Explain why the plasma membrane is called a differentially permeable or selectively pe ...
Dialogue between skin microbiota and immunity
... the initiation and amplification of immune responses (28). Of note, AMPs, the complement system, and IL-1 all represent ancient arms of the innate immune system, suggesting that these pathways may have arisen as early mediators of host skin-commensal interaction. Control of adaptive immunity by skin ...
... the initiation and amplification of immune responses (28). Of note, AMPs, the complement system, and IL-1 all represent ancient arms of the innate immune system, suggesting that these pathways may have arisen as early mediators of host skin-commensal interaction. Control of adaptive immunity by skin ...
Restoring the Balance of the Autonomic Nervous System as an
... on immune cells, is adaptive to environmental needs. In addition, immune function is regulated by peptide neurotransmitters that colocalize with NE, such as neuropeptide Y and adenosine triphosphate (ATP), as well, but their exact contribution to immune regulation remains to be unraveled (12). The r ...
... on immune cells, is adaptive to environmental needs. In addition, immune function is regulated by peptide neurotransmitters that colocalize with NE, such as neuropeptide Y and adenosine triphosphate (ATP), as well, but their exact contribution to immune regulation remains to be unraveled (12). The r ...
In vitro and in vivo model of a novel immunotherapy
... The targets tested included Jeko-1, BJAB, and LCL cells labeled with 25Ci of 51Cr (Perkin-Elmer) for 45 minutes, as well as primary CLL cells and normal B lymphocytes, each labeled with 50 Ci of 51Cr for 1 hour. Target cells (5 ⫻ 103) were then cocultured in triplicate with T cells at effector:tar ...
... The targets tested included Jeko-1, BJAB, and LCL cells labeled with 25Ci of 51Cr (Perkin-Elmer) for 45 minutes, as well as primary CLL cells and normal B lymphocytes, each labeled with 50 Ci of 51Cr for 1 hour. Target cells (5 ⫻ 103) were then cocultured in triplicate with T cells at effector:tar ...
Gene Section ORAI3 (ORAI calcium release-activated calcium modulator 3)
... treated with 2µg/ml tunicamycin, showed that ORAI3 migrated at positions close to their predicted molecular masse (32.5 kDa). Phosphorylation: Since ORAI3 is a tetraspanning plasma membrane protein, it contains three intracellular regions that can potentially be phosphorylated by intracellular prote ...
... treated with 2µg/ml tunicamycin, showed that ORAI3 migrated at positions close to their predicted molecular masse (32.5 kDa). Phosphorylation: Since ORAI3 is a tetraspanning plasma membrane protein, it contains three intracellular regions that can potentially be phosphorylated by intracellular prote ...
HLA-A*02 AND ITS PROGNOSTIC TRAITS IN CANCER.
... ovarian cancer (EOC) to determine HLA-A, -B, -Cw and -DRB1. The results showed an unusual representation of HLA alleles in EOC compared to healthy Swedish bone-marrow donors where HLA-A*02 was overrepresented, also HLA-A*02 homozygotes were two-fold higher among EOC patients. The frequency of HLA-A* ...
... ovarian cancer (EOC) to determine HLA-A, -B, -Cw and -DRB1. The results showed an unusual representation of HLA alleles in EOC compared to healthy Swedish bone-marrow donors where HLA-A*02 was overrepresented, also HLA-A*02 homozygotes were two-fold higher among EOC patients. The frequency of HLA-A* ...
keystone exam format - Souderton Area High School
... Key: Most lipid molecules have long hydrocarbon chains as the main component of their structures. The molecule described has a long hydrocarbon chain with a phosphate group, which is a phospholipid. Protein molecules are made of amino acids. Nucleic acid molecules are made of nucleotides. Carbohydra ...
... Key: Most lipid molecules have long hydrocarbon chains as the main component of their structures. The molecule described has a long hydrocarbon chain with a phosphate group, which is a phospholipid. Protein molecules are made of amino acids. Nucleic acid molecules are made of nucleotides. Carbohydra ...
Principles of Transplantation
... production of IL-4/IL-5 promoting the production of Bcells and release of graft specific antibodies ...
... production of IL-4/IL-5 promoting the production of Bcells and release of graft specific antibodies ...
Doctoral thesis from the Department of Immunology,
... lysosomes; avoid exposure to the bactericidal mechanisms within lysosomes; prevent degradation and hence processing and presentation of mycobacterial antigens to the immune system [20]. Another mechanism by which mycobacteria could interfere with phagolysosomal fusion is by retention of an important ...
... lysosomes; avoid exposure to the bactericidal mechanisms within lysosomes; prevent degradation and hence processing and presentation of mycobacterial antigens to the immune system [20]. Another mechanism by which mycobacteria could interfere with phagolysosomal fusion is by retention of an important ...
The role of heat shock proteins in reproduction
... many species. Finally, HSP are immunodominant antigens of numerous microbial pathogens, e.g. Chlamydia trachomatis, which have been recognized as the main cause of tubal infertility. Many couples with fertility problems have had a previous genital tract infection, have become sensitized to microbial ...
... many species. Finally, HSP are immunodominant antigens of numerous microbial pathogens, e.g. Chlamydia trachomatis, which have been recognized as the main cause of tubal infertility. Many couples with fertility problems have had a previous genital tract infection, have become sensitized to microbial ...
chapter 16 the adaptive immune response
... Clonal selection is the process by which some lymphocytes are destroyed and others are ...
... Clonal selection is the process by which some lymphocytes are destroyed and others are ...
Activation of Innate Immune Responses by Non
... DC maturation and migration of the cells into local lymph nodes, where antigen presentation to naïve T cells and induction of adaptive immune responses takes place. During activation these cells produce cytokines, soluble mediators that regulate host immune responses. Recognition of microbes is regu ...
... DC maturation and migration of the cells into local lymph nodes, where antigen presentation to naïve T cells and induction of adaptive immune responses takes place. During activation these cells produce cytokines, soluble mediators that regulate host immune responses. Recognition of microbes is regu ...
ABSTRACT Title of Document:
... present on invading microorganisms by the host cells. These structures, called pathogenassociated molecular patterns (PAMPs) are recognized by pathogen recognition receptors (PRRs) expressed on host cells [5]. They are germline encoded, non-clonal receptors which rapidly activate effector cells. Leu ...
... present on invading microorganisms by the host cells. These structures, called pathogenassociated molecular patterns (PAMPs) are recognized by pathogen recognition receptors (PRRs) expressed on host cells [5]. They are germline encoded, non-clonal receptors which rapidly activate effector cells. Leu ...
Lymphatic System - El Camino College
... Right Lymphatic duct – collects lymph from right arm, right side of head, neck and thorax. When absent, the lymphatic trunks directly open into veins of the neck. Thoracic Duct – collects lymph from rest of the body. It arises inferiorly as an extended sac – Cisterna Chyli, in front of 1st and 2nd l ...
... Right Lymphatic duct – collects lymph from right arm, right side of head, neck and thorax. When absent, the lymphatic trunks directly open into veins of the neck. Thoracic Duct – collects lymph from rest of the body. It arises inferiorly as an extended sac – Cisterna Chyli, in front of 1st and 2nd l ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.