Molecular Cell Biology
... anaphase-promoting complex A ubiquitin ligase that triggers progression from metaphase to anaphase by signaling the degradation of cyclin B and cohesins. angiogenesis The formation of new blood vessels. antibody A protein produced by B lymphocytes that binds to a foreign molecule. anticodon The nucl ...
... anaphase-promoting complex A ubiquitin ligase that triggers progression from metaphase to anaphase by signaling the degradation of cyclin B and cohesins. angiogenesis The formation of new blood vessels. antibody A protein produced by B lymphocytes that binds to a foreign molecule. anticodon The nucl ...
Autoimmune Diseases - The Dartmouth Undergraduate Journal of
... into the thyroids of the rabbits from which it was originally derived, and noticed that the rabbits soon developed lesions in their thyroid tissue—a sign deduced to be an autoimmune response similar to that of a known condition called Hashimoto’s Thyroiditis (3). Yet, despite Rose’s discovery, over ...
... into the thyroids of the rabbits from which it was originally derived, and noticed that the rabbits soon developed lesions in their thyroid tissue—a sign deduced to be an autoimmune response similar to that of a known condition called Hashimoto’s Thyroiditis (3). Yet, despite Rose’s discovery, over ...
Survival strategies of inside the human macrophage Mycobacterium tuberculosis Amanda Welin
... microbes. Mtb is able to evade macrophage responses in part by inhibiting the fusion between the phagosome in which it resides and bactericidal lysosomes, as well as by dampening the acidification of the vacuole. The initial macrophage infection results in a pro-inflammatory response and the recruit ...
... microbes. Mtb is able to evade macrophage responses in part by inhibiting the fusion between the phagosome in which it resides and bactericidal lysosomes, as well as by dampening the acidification of the vacuole. The initial macrophage infection results in a pro-inflammatory response and the recruit ...
28-29_Per_tolerance_Regulatory T-cells_LA
... absence of co-stimulation or innate immunity may make the cells incapable of responding to that antigen. Regulatory T lymphocytes are a subset of CD4+ T-cells whose function is to suppress immune responses and maintain selftolerance. T-cells that recognize self antigens with high affinity or are rep ...
... absence of co-stimulation or innate immunity may make the cells incapable of responding to that antigen. Regulatory T lymphocytes are a subset of CD4+ T-cells whose function is to suppress immune responses and maintain selftolerance. T-cells that recognize self antigens with high affinity or are rep ...
Characterization of the binding properties of the Avian Coronavirus
... 4.2.1 Deletion of 42 AA near the N-terminus of the spike protein results in a reduced binding of the IBV spike protein............................................................ 59 ...
... 4.2.1 Deletion of 42 AA near the N-terminus of the spike protein results in a reduced binding of the IBV spike protein............................................................ 59 ...
Award Recipients 2015
... image initial lymphatic vessels and measure lymphatic pumping pressure, ii) Doppler optical coherence tomography (DOCT) to measure lymph velocity, and iii) intravital imaging to measure contraction strength, frequency, and valve dynamics. These established methods, including the first measurement of ...
... image initial lymphatic vessels and measure lymphatic pumping pressure, ii) Doppler optical coherence tomography (DOCT) to measure lymph velocity, and iii) intravital imaging to measure contraction strength, frequency, and valve dynamics. These established methods, including the first measurement of ...
Lymph Glands (lymphoglandulae)
... The sites of B cell homing include: 1. The primary and secondary follicles of the lymph node cortex-the sites of antigen presentation to B cells, and subsequent proliferation and differentiation in response to same. 2. The medullary cords, where plasma cells aggregate, and release their immunoglobul ...
... The sites of B cell homing include: 1. The primary and secondary follicles of the lymph node cortex-the sites of antigen presentation to B cells, and subsequent proliferation and differentiation in response to same. 2. The medullary cords, where plasma cells aggregate, and release their immunoglobul ...
Lung interstitial macrophages alter dendritic Research article
... innocuous antigen uptake and, therefore, stimulate the development of antigen-specific Tregs (1, 2). Similarly, lung plasmacytoid DCs protect against aberrant immune responses to inhaled antigens by inducing Tregs (3). Epidemiological studies have shown that ambient air contains not only inert antig ...
... innocuous antigen uptake and, therefore, stimulate the development of antigen-specific Tregs (1, 2). Similarly, lung plasmacytoid DCs protect against aberrant immune responses to inhaled antigens by inducing Tregs (3). Epidemiological studies have shown that ambient air contains not only inert antig ...
Common Genetic Variants Found in HLA and KIR Immune Genes in
... long term immunological memory is invoked. Memory involves the recognition of antigens from invading organism for extended periods of time, often decades. This is accomplished by the creation of tailor-made memory cells. Antibodies are the main soluble component of the adaptive system; however, cyto ...
... long term immunological memory is invoked. Memory involves the recognition of antigens from invading organism for extended periods of time, often decades. This is accomplished by the creation of tailor-made memory cells. Antibodies are the main soluble component of the adaptive system; however, cyto ...
Final Program - Cancer Research Institute
... Recent clinical success in the antigen independent activation of cytotoxic T cells has highlighted the potential of immune activation as a therapeutic strategy for the treatment of neoplastic diseases. However, such nonspecific activation can result in considerable toxicity as a consequence of cytok ...
... Recent clinical success in the antigen independent activation of cytotoxic T cells has highlighted the potential of immune activation as a therapeutic strategy for the treatment of neoplastic diseases. However, such nonspecific activation can result in considerable toxicity as a consequence of cytok ...
Immune components of bovine colostrum and milk
... A wide variety of components linked to the innate immune response have been identified in colostrum and milk. These include neutrophils, macrophages, complement, oligosaccharides, gangliosides, reactive oxygen species, acute-phase proteins, immunomodulatory factors (including many different pro- and ...
... A wide variety of components linked to the innate immune response have been identified in colostrum and milk. These include neutrophils, macrophages, complement, oligosaccharides, gangliosides, reactive oxygen species, acute-phase proteins, immunomodulatory factors (including many different pro- and ...
cell biology and membrane biochemistry
... those of nucleus, endoplasmic reticulum, golgi apparatus, mitochondria, lysosomes, perioxisomes and vacuoles. Plant cells, in addition to the above, have those of choloroplasts. These intracellular membranes separate the cells into compartments with an identity of their own to carry out specific fun ...
... those of nucleus, endoplasmic reticulum, golgi apparatus, mitochondria, lysosomes, perioxisomes and vacuoles. Plant cells, in addition to the above, have those of choloroplasts. These intracellular membranes separate the cells into compartments with an identity of their own to carry out specific fun ...
Doctoral thesis from the Department of Immunology,
... observed when using this plant might not only be due to the direct action on the Leishmania parasite, but possibly to a parallel effect on the host immune response to the parasite. We first determined the toxicity of an alkaloid extract of Evanta (AEE) on eukaryotic cells in vitro and afterwards ana ...
... observed when using this plant might not only be due to the direct action on the Leishmania parasite, but possibly to a parallel effect on the host immune response to the parasite. We first determined the toxicity of an alkaloid extract of Evanta (AEE) on eukaryotic cells in vitro and afterwards ana ...
Evasion of Host Immune Surveillance by Hepatitis C Virus: Potential
... Like many RNA viruses, HCV demonstrates considerable genetic heterogeneity due to a low-fidelity RNA polymerase lacking the proof-reading capability of a 3’–5’ exconuclease activity15, 20. The rate of nucleotide misincorporation in the HCV genome has been estimated at up to 104 base substitutions pe ...
... Like many RNA viruses, HCV demonstrates considerable genetic heterogeneity due to a low-fidelity RNA polymerase lacking the proof-reading capability of a 3’–5’ exconuclease activity15, 20. The rate of nucleotide misincorporation in the HCV genome has been estimated at up to 104 base substitutions pe ...
Development of a 99mTc-labeled lactam bridge-cyclized alpha
... to be that peptide receptors are over-expressed by certain tumors [1–3]. Up to now, several types of peptides have been introduced for tumor targeting, and many types of cancer cells have demonstrated overexpression of various peptide receptors [4, 5]. Alpha-Melanocyte stimulating hormone (a-MSH) is ...
... to be that peptide receptors are over-expressed by certain tumors [1–3]. Up to now, several types of peptides have been introduced for tumor targeting, and many types of cancer cells have demonstrated overexpression of various peptide receptors [4, 5]. Alpha-Melanocyte stimulating hormone (a-MSH) is ...
as a PDF
... deficiency in humans. Zinc could also be critical for some cytokine activity. For instance, it has been demonstrated that the production or the biological activity of IL-1, IL-2, IL-3, IL4, IL-6, IFN-g and TNF-a are affected by zinc deficiency. In addition, and as mentioned above, zinc deficiency in ...
... deficiency in humans. Zinc could also be critical for some cytokine activity. For instance, it has been demonstrated that the production or the biological activity of IL-1, IL-2, IL-3, IL4, IL-6, IFN-g and TNF-a are affected by zinc deficiency. In addition, and as mentioned above, zinc deficiency in ...
The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the
... with a CD4/CD8 ratio less/greater than 1. The present study demonstrates that individuals with an inverted CD4/CD8 ratio reveal an immune profile consisting of high CD8 and low CD4 and CD19 percentages, associated with seropositivity to CMV as well as to significant increases in the number of lately ...
... with a CD4/CD8 ratio less/greater than 1. The present study demonstrates that individuals with an inverted CD4/CD8 ratio reveal an immune profile consisting of high CD8 and low CD4 and CD19 percentages, associated with seropositivity to CMV as well as to significant increases in the number of lately ...
Cancer immunotherapy - Italian Sarcoma Group
... CD4+FOXP3+ Tregs. The lymphopenic environment eliminates Tregs and myeloid-derived suppressor cells, but it also eliminates competition for homeostatic cytokines such as interleukin-7 (IL-7) and IL-15 that are vital for survival. In the lymphopenic host, these antitumor T cells can proliferate thous ...
... CD4+FOXP3+ Tregs. The lymphopenic environment eliminates Tregs and myeloid-derived suppressor cells, but it also eliminates competition for homeostatic cytokines such as interleukin-7 (IL-7) and IL-15 that are vital for survival. In the lymphopenic host, these antitumor T cells can proliferate thous ...
List of Publications: As a Corresponding/Senior Author 1. Tumor
... 10. NK cellular cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of IL-12 (2007). Bose A and Baral RN, Human Immunol, 68, 823-831. Impact Factor: 3.06; Citation Index: 36 ...
... 10. NK cellular cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of IL-12 (2007). Bose A and Baral RN, Human Immunol, 68, 823-831. Impact Factor: 3.06; Citation Index: 36 ...
The Role of Complement in Tumor Growth Chapter 11
... of the MAC into the membrane (Podack and Muller-Eberhard 1979; Jenne and Tschopp 1989). Clusterin can also modulate cell differentiation and regulate the production of major pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 (Falgarone and Chiocchia 2009). Comple ...
... of the MAC into the membrane (Podack and Muller-Eberhard 1979; Jenne and Tschopp 1989). Clusterin can also modulate cell differentiation and regulate the production of major pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 (Falgarone and Chiocchia 2009). Comple ...
Signal Transduction (Medical Biotechnology)
... Soluble mediators transmit information through the extracellular space over various distances in cell-to cell communication. In local (short distance) cell signaling, some cells may be in direct contact with each other in order to communicate. Cell-to-cell signaling means that mediators can pass fro ...
... Soluble mediators transmit information through the extracellular space over various distances in cell-to cell communication. In local (short distance) cell signaling, some cells may be in direct contact with each other in order to communicate. Cell-to-cell signaling means that mediators can pass fro ...
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... (OD=450nm), sex (Female), age (>4-6 years) and breed (Borno Even though cELISA does not allow cross reaction with vaccinal antibodies, concomitant with other studies, it has been shown that cELISA was incapable of detecting all CBPP infected cattle. This may possibly be a reason in addition to the a ...
... (OD=450nm), sex (Female), age (>4-6 years) and breed (Borno Even though cELISA does not allow cross reaction with vaccinal antibodies, concomitant with other studies, it has been shown that cELISA was incapable of detecting all CBPP infected cattle. This may possibly be a reason in addition to the a ...
QUESTION
... • ANSWER: The order of 4 substances in a well in a positive ELISA test for HIV. • QUESTION: What is antigen, human antibody, Secondary antibody or rabbit antibody, and substrate? ...
... • ANSWER: The order of 4 substances in a well in a positive ELISA test for HIV. • QUESTION: What is antigen, human antibody, Secondary antibody or rabbit antibody, and substrate? ...
Final Program Florence, Italy October 9-12, 2011 9th JOINT MEETING
... R. Piganis, N. de Weerd, J. Gould, B. Scott, S. Forster, S. Nicholson and P. Hertzog, USA TRIM proteins regulate the innate immune response G.A. Versteeg, R. Rajsbaum, M.T. Sánchez-Aparicio, J. Valdiviezo, M. Shi, K.S. Inn, J. J. and A. García-Sastre, USA IRF-1 phosphorylation by I-kappa-B kinase ep ...
... R. Piganis, N. de Weerd, J. Gould, B. Scott, S. Forster, S. Nicholson and P. Hertzog, USA TRIM proteins regulate the innate immune response G.A. Versteeg, R. Rajsbaum, M.T. Sánchez-Aparicio, J. Valdiviezo, M. Shi, K.S. Inn, J. J. and A. García-Sastre, USA IRF-1 phosphorylation by I-kappa-B kinase ep ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.