MM-BMSCs induce naïve CD4+ T lymphocytes
... T-cell apoptosis and increased Th17/Treg ratio have been observed during the co-culture of CD4+T-cells with MMBMSCs compared to the co-cultures with healthy donor (HD) BMSCs [9]. The fibroblast activation protein α (FAPα) is known to be associated with immunosuppression in the tumor. FAPα is a membe ...
... T-cell apoptosis and increased Th17/Treg ratio have been observed during the co-culture of CD4+T-cells with MMBMSCs compared to the co-cultures with healthy donor (HD) BMSCs [9]. The fibroblast activation protein α (FAPα) is known to be associated with immunosuppression in the tumor. FAPα is a membe ...
EIR 14
... the role of different surface molecules from salmonella in the reduction of voluntary physical activity associated with infection. They demonstrate that it is induced by flagella antigens, mediated through TLR5. Neubauer et al. then thoroughly review the role of DNA damage in the reaction of the org ...
... the role of different surface molecules from salmonella in the reduction of voluntary physical activity associated with infection. They demonstrate that it is induced by flagella antigens, mediated through TLR5. Neubauer et al. then thoroughly review the role of DNA damage in the reaction of the org ...
Enrichment of IFN-γ producing cells in different murine adipose
... Here we report that lean mice infected with the intracellular parasite Neospora caninum show a fast but sustained increase in the frequency of IFN-γ-producing cells noticeable in distinct adipose tissue depots. Moreover, IFN-γ-mediated immune memory could be evoked in vitro in parasite antigen-stimu ...
... Here we report that lean mice infected with the intracellular parasite Neospora caninum show a fast but sustained increase in the frequency of IFN-γ-producing cells noticeable in distinct adipose tissue depots. Moreover, IFN-γ-mediated immune memory could be evoked in vitro in parasite antigen-stimu ...
Suppression of adaptive immune responses during primary SIV
... transfer of broadly NAbs.13,14 Recently, a limited number of studies have evaluated the role of B cell–mediated immune responses in SIV containment in rhesus macaques.15-17 Humoral immune responses did not contribute to viral containment in primary infection,15 but an accelerated disease progression ...
... transfer of broadly NAbs.13,14 Recently, a limited number of studies have evaluated the role of B cell–mediated immune responses in SIV containment in rhesus macaques.15-17 Humoral immune responses did not contribute to viral containment in primary infection,15 but an accelerated disease progression ...
R E V I E W S
... Box 1 | Insights into the molecular basis of granule-mediated cell death The most important recent findings in terms of the physiological function of the granuleexocytosis pathway are listed below. • Perforin and granzymes induce target-cell apoptosis cooperatively. Granzymes are necessary for trigg ...
... Box 1 | Insights into the molecular basis of granule-mediated cell death The most important recent findings in terms of the physiological function of the granuleexocytosis pathway are listed below. • Perforin and granzymes induce target-cell apoptosis cooperatively. Granzymes are necessary for trigg ...
Bone transplantation and immune response
... cells are unlikely to survive and thus NK cells do not have a role in cryoallograft rejection.9,12 T cells express receptors on the surface that are able to recognise either the whole MHC molecules (direct recognition) or MHC molecules presenting non-self peptide on their peptide-binding group (indi ...
... cells are unlikely to survive and thus NK cells do not have a role in cryoallograft rejection.9,12 T cells express receptors on the surface that are able to recognise either the whole MHC molecules (direct recognition) or MHC molecules presenting non-self peptide on their peptide-binding group (indi ...
Focus Article
... make the individual patient uniquely susceptible to developing a particular pattern of chronic pain. ...
... make the individual patient uniquely susceptible to developing a particular pattern of chronic pain. ...
ABSTRACT Title of Document:
... required for WASP and N-WASP activation. Inhibition of Btk activity by a point mutation or a specific inhibitor prevents BCR-induced increases in PtdIns-4,5-P2 as well as in phosphorylated WASP, N-WASP and Vav. Furthermore, Btk deficiency or inhibition leads to a severe reduction in BCR-mediated an ...
... required for WASP and N-WASP activation. Inhibition of Btk activity by a point mutation or a specific inhibitor prevents BCR-induced increases in PtdIns-4,5-P2 as well as in phosphorylated WASP, N-WASP and Vav. Furthermore, Btk deficiency or inhibition leads to a severe reduction in BCR-mediated an ...
IMMUNOREACTIONS INVOLVING PLATELETS. VI. REACTIONS OF
... spontaneous delivery; all developed petechiae and ecchymoses within 1 to 6 hours after birth and had severe thrombocytopenia, but their hemoglobin and leukocyte counts were normal and they had no other congenital defects. The four mothers were in good health, had normal platelet levels shortly after ...
... spontaneous delivery; all developed petechiae and ecchymoses within 1 to 6 hours after birth and had severe thrombocytopenia, but their hemoglobin and leukocyte counts were normal and they had no other congenital defects. The four mothers were in good health, had normal platelet levels shortly after ...
Mainstream- Fringe- and Patho- Physiology of Voltage Dependent
... and explanation for the expression of these highly voltage sensitive channels in non-excitable cells that do not fire AP. Ion channel activity is an important factor in volume regulation and the associated motility of cells. A related mechanism is suggested for the ability to migrate, acquired by tr ...
... and explanation for the expression of these highly voltage sensitive channels in non-excitable cells that do not fire AP. Ion channel activity is an important factor in volume regulation and the associated motility of cells. A related mechanism is suggested for the ability to migrate, acquired by tr ...
P R M
... well conserved during evolution. A considerable number of genes encoding recognition molecules, as well as effector molecules, and components of signaling pathways, are conserved from organisms as divergent as humans and flies. These genes must thus have been present in the common ancestor to insect ...
... well conserved during evolution. A considerable number of genes encoding recognition molecules, as well as effector molecules, and components of signaling pathways, are conserved from organisms as divergent as humans and flies. These genes must thus have been present in the common ancestor to insect ...
dependent regulation of intestinal immunity and homeostasis
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
HIC1 links retinoic acid signalling to group 3 innate
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
... The intestinal immune system is held in a tightly regulated balance between immune activation in response to potential pathogens and the maintenance of tolerance to innocuous antigens, such as food and commensal flora. Disruption of this balance can lead to the development of serious inflammatory di ...
Plasma is the main regulator of Staphylococcus epidermidis biofilms
... a central role in biofilm development/maturation such as aap (Hussain et al. 1997; Rohde et al. 2005), bhp (Tormo et al. 2005), icaA (Mack et al. 1996) and lrgB (Bayles 2007) and in immune evasion such as icaA (Cerca et al. 2006; Kristian et al. 2008), capA (Kocianova et al. 2005), mprF/fmtC (Gill e ...
... a central role in biofilm development/maturation such as aap (Hussain et al. 1997; Rohde et al. 2005), bhp (Tormo et al. 2005), icaA (Mack et al. 1996) and lrgB (Bayles 2007) and in immune evasion such as icaA (Cerca et al. 2006; Kristian et al. 2008), capA (Kocianova et al. 2005), mprF/fmtC (Gill e ...
Immunoflourescence in dermatopathology
... histological section of human skin prepared for direct immunofluorescence using an anti-IgG antibody. The skin is from a patient with systemic lupus erthematosus and shows IgG deposit at two different places: The first is a band-like deposit along the epidermal basement membrane ("lupus band test" i ...
... histological section of human skin prepared for direct immunofluorescence using an anti-IgG antibody. The skin is from a patient with systemic lupus erthematosus and shows IgG deposit at two different places: The first is a band-like deposit along the epidermal basement membrane ("lupus band test" i ...
Autobio`s complete product list
... AFP CLIA for the quantitative determination of alpha feto-Protein in human serum. CEA CLIA for the quantitative determination of carcinoembryonic antigen in human serum. PSA CLIA for the quantitative determination of prostate specific antigen (PSA) in Human Serum. f-PSA CLIA for the quantitative det ...
... AFP CLIA for the quantitative determination of alpha feto-Protein in human serum. CEA CLIA for the quantitative determination of carcinoembryonic antigen in human serum. PSA CLIA for the quantitative determination of prostate specific antigen (PSA) in Human Serum. f-PSA CLIA for the quantitative det ...
Peroxisome Proliferator-Activated Receptors (PPARs)
... e.g., Nurr1 from ER to VDR from FXR to PPAR ...
... e.g., Nurr1 from ER to VDR from FXR to PPAR ...
a mathematical simulation of the inflammatory response to anthrax
... spores that are ingested by resting macrophages. Then, we consider the events after spore germination at t = 0. The growing bacteria release protective antigen, lethal factor, and edema factor (but no endotoxin), which combine, as previously described, to form lethal toxin and edema toxin. Lethal to ...
... spores that are ingested by resting macrophages. Then, we consider the events after spore germination at t = 0. The growing bacteria release protective antigen, lethal factor, and edema factor (but no endotoxin), which combine, as previously described, to form lethal toxin and edema toxin. Lethal to ...
Ginkgo biloba extract EGb 761 has anti
... concentrations of EGb 761. EGb 761 was washed off and then media containing IFN-c to stimulate cells were added. Following 6 h, cells were harvested for protein and examined for a response with iNOS being the inflammation marker. The negative control () is ANA-1 cells not exposed to IFN-c. (B) Usin ...
... concentrations of EGb 761. EGb 761 was washed off and then media containing IFN-c to stimulate cells were added. Following 6 h, cells were harvested for protein and examined for a response with iNOS being the inflammation marker. The negative control () is ANA-1 cells not exposed to IFN-c. (B) Usin ...
Passive or Active Immunization with Myelin Basic Protein Promotes
... adult rat spinal cord (Hauben et al., 2000). We have shown previously that the neuroprotective effect of the autoimmune T cells is mediated, at least in part, by neurotrophic factors, the secretion of which is antigen-dependent (G. Moalem, A. Gdalyahu, Y. Shani, U. Otten, P. Lazarovici, I. R. Cohen, ...
... adult rat spinal cord (Hauben et al., 2000). We have shown previously that the neuroprotective effect of the autoimmune T cells is mediated, at least in part, by neurotrophic factors, the secretion of which is antigen-dependent (G. Moalem, A. Gdalyahu, Y. Shani, U. Otten, P. Lazarovici, I. R. Cohen, ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.