Download Examples of Supervisors and Research Projects (Wellcome)

The Imperial Immunity, Inflammation, Infection and Informatics (4i) Clinician Scientist PhD
Programme
Examples of Potential Supervisors and PhD project titles
Please note that 1) this list is not exhaustive; and 2) is subject to change.
IMMUNITY
Potential Supervisor
Prof Martin Allday
Prof Danny Altmann
Dr Darius Armstrong-James
Dr Becca Asquith
Prof Charles Bangham
Prof Sebastian Johnston
Prof Beate Kampmann
Prof Anastasios Karadimitris
Dr George Kassiotis
Prof Ajit Lalvani
Dr James Leiper
Prof Matthias Merkenschlager
Dr Anne O’Garra
Prof Peter Openshaw
Prof Caetano Reis e Sousa
Prof Victor Tybulewicz
Prof Robert Wilkinson
INFLAMMATION
Potential Supervisor
Prof John Bassett
Dr Jacques Behmoaras
Prof Sir Stephen Bloom
Prof Marina Botto
Prof Andrew Bush
Prof Waljit Dhillo
Dr Nadia Guerra
Dr James Harker
Dr Mark Isalan
Prof Steve Ley
Prof Clare Lloyd
Example of PhD project
Re-programming of B cells by Epstein-Barr virus
Immune correlates of Zika virus exposure.
Modulation of macrophage cell death in pulmonary aspergillosis
Mathematical modelling of the impact of CD8+ T cell dynamics on
the control of persistent viral infection
The autologous anti-tumour T-cell response to HTLV-1-induced
leukaemia
Role of host dsDNA and NETs in rhinovirus-induced exacerbation
of allergic airway inflammation
Using the transcriptome of infant EPI vaccines to predict correlates
of protection
iNKT cell immunotherapy for haematopoietic stem cell
transplantation and B cell lymphomas
Tuning of immune reactivity by endogenous retroviruses:
mechanisms and consequences
Immunity to TB infection: correlates of resistance and clearance in
the human lung
The role of endogenous inhibitors of nitric oxide synthesis in
regulation of the innate immune response to sepsis.
Gene regulation in the immune system
Transcriptional regulation of IL-10 versus proinflammatory cytokine
production in myeloid cells via type I IFN dependent and
independent mechanisms in mouse models and human disease
including infection and allergy
Immune regulation of B cells in RSV infection of human volunteers
Immunity to cancer induced by dendritic cells
Signaling pathways controlling B cell survival
Role of Sirtuins, PARPS, Resolvins and Eicosanoids in
hyperinflammatory HIV-associated tuberculosis: the immune
reconstitution inflammatory syndrome (TB-IRIS)
Example of PhD project
The role of Daam2 and non-canonical wnt signalling in the
pathogenesis of osteoporosis
Macrophage plasticity in systemic sclerosis
Adipose and pancreatic inflammatory signals as a major cause of
insulin resistance
The role of complement C1q in angiogenesis - implications for
tissue regeneration
The role of lineage negative innate lymphoid cells in paediatric
asthma
Hypothalamic inflammation in the control of metabolic function
The role of natural killer cell receptors
The role of IL-17A in the formation of lung lymphoid structures in
chronic inflammation
A multi-systemic double targeted therapeutic strategy for
Huntington’s disease
Regulation of innate immunity by TPL-2 kinase
Molecular mechanisms underlying development of preschool
wheeze: the role of gene: environment interactions
The Imperial Immunity, Inflammation, Infection and Informatics (4i) Clinician Scientist PhD
Programme
Dr Cristina Lo Celso
Prof Miriam Moffatt
Prof Matthew Pickering
Prof Sarah Rankin
Prof Molly Stevens
Dr Joanthan Stoye
Dr Jessica Strid
Prof Sivaramesh Wigneshweraraj
Prof Martin Wilkins
Prof Graham Williams
INFECTION
Potential Supervisor
Prof Wendy Barclay
Dr Jake Baum
Dr Peter Cherepanov
Prof George Christophides
Dr Fiona Culley
Dr Christl Donnelly
Dr Marcus Dorner
Prof Gad Frankel
Prof Jonathan Friedland
Prof Neil Ferguson
Prof Azra Ghani
Prof Nicholas Grassly
Prof Angelika Grundling
Prof David Holden
Prof Alison Holmes
Prof Michael Levin
Dr Geodele Maertens
Dr Serge Mostowy
Prof Gloria Rudenko
Short- and long-term consequences of inflammation on
haematopoietic stem and progenitor cells, from in vivo murine
experimental models to clinical data
Omic Investigations of co-culture of bacterial isolates with human
bronchial epithelial cells differentiated at the air liquid interface
The role of complement deregulation in glomerulonephritis
Effects of lung inflammation on the activity of mesenchymal stem
cells
Designing Biomaterials for Cellular Applications
Natural variation in lentiviral accessory proteins
The role of type 2 immunity in tissue homeostasis and tumour
immune-surveillance in the skin
Phage-inspired solutions to combat antibacterial resistance
Application of Mendelian randomization to identify inflammation
targets for the treatment of pulmonary hypertension
Role of local thyroid hormone metabolism in chronic inflammation
and tissue repair
Example of PhD project
Identification and characterization of human host factors that affect
the outcome of influenza virus infection
The role of the erythrocyte cytoskeleton and membrane in malaria
parasite invasion of the red blood cell
Host factors involved in retroviral DNA integration
Characterisation of plasmodium vivax transmission in the Amazon
Age related changes to innate anti-viral immunity in the lung
Exploration of heterogeneity in the West African Ebola outbreak transmission, health-seeking behaviour and control
The role of nuclear import of hepatitis B virus capsids on viral
persistence and host restriction
The impact of antibiotic treatment and diet on pathogen host
interaction and the microbiota
Investigating host directed therapies to decrease tissue damage in
tuberculosis
Characterising the relationship between prior antibody titre and
disease severity in dengue infection and modelling the
consequences for vaccine impact
Estimating the impact and incremental cost-effectiveness of
regional co-operation strategies for moving towards malaria
elimination in sub-Saharan Africa.
Identifying the cause of poor oral rotavirus vaccine efficacy in lowincome settings
Investigate the mechanism by which the singalling nucleotide c-diAMP impacts the mecithillin resistance and biofilm formation
in Staphylococcus aureus.
How Salmonella virulence proteins interfere with innate and
adaptive immunity
Antimicrobial Resistance and Healthcare Associated Infections - a
global problem
Integrating genomic variation and RNA expression data from TB
and severe bacterial infection to understand immunopathogenesis
Identification and characterization of beta-retroviral integrase
binding proteins
Use of Shigella flexneri to discover new roles for the cytoskeleton in
cell-autonomous immunity
The role of the Variant Surface Glycoprotein coat in immune
evasion in the African trypanosome Trypanosoma brucei
The Imperial Immunity, Inflammation, Infection and Informatics (4i) Clinician Scientist PhD
Programme
Prof Shiranee Sriskandan
Dr Michael Way
Prof Dale Wigley
Prof Thomas Williams
Prof Xiaodong Zhang
INFORMATICS
Potential Supervisor
Prof Paul Aylin
Prof Mauricio Barahona
Dr Marc Chadeau-Hyam
Prof Stuart Cook
Prof William Cookson
Prof Adnan Custovic
Dr Timothy Ebbels
Prof Paul Elliott
Prof Majid Ezzati
Prof Jorge Ferrer
Prof Amanda Fisher
Prof Paul Freemont
Prof Yike Guo
Dr Petra Hajkova
Dr Oliver Howes
Prof Boris Lenhard
Prof Azeem Majeed
Dr Irene Miguel-Aliaga
Prof Jeremy Nicholson
Prof Elio Riboli
Prof David Rueda
Dr Ioanna Tzoulaki
Dr Tobias Warnecke
The Return of Scarlet Fever and Extreme Streptococcal
Phenotypes
The role of Arp2/3 isoforms in development and tissue homeostasis
Targeting bacterial DNA repair systems for antibiotic development
Mechanisms of malaria protection afforded by recently identified
Glycophorin mutations in the Kilifi population.
Structural basis of transcription regulation of bacteria stress
response and a new strategy for antibiotic development
Example of PhD project
The role of electronic patient records in averting failure to rescue
events in hospital patients
From ‘omics data to landscapes: dimensionality reduction and
clustering through geometric graphs in single cell data
Combining dynamic models and feature selection algorithms to
identify OMIC biomarkers involved in the natural history of chronic
disease progression: application to genetic, epigenetic and gene
expression data for lung cancer
Dissection of RNA-sequencing, ribo-sequencing and miRNA
signatures to understand cardiovascular disease mechanisms
Metagenomics of the lung microbiome in health and disease
Integrating complex data structures to identify subtypes of
childhood asthma: a probabilistic machine learning approach
New tools for analysis of short highly multivariate time series in
genomics and metabolomics
Multi-omic approaches to understanding the aetiology and
pathogenesis of cardiometabolic disorders
Bayesian ensemble models for population health forecasts
Role of non-coding genome variation in human diabetes
Integrating cell cycle control and pluripotency in stem cells
Developing novel synthetic biology biosensors for the detection of
disease biomarkers
Identifying biomarkers for respiratory diseases using deep learning
The role of DNA modification interplay in epigenetic reprogramming
Determining the effect of neuroinflammation on brain functional
networks
The Role of Long-Range Developmental Regulation in
Understanding Disease Variation and Mechanism
Using data from electronic primary care records for disease
surveillance
The transcriptional plasticity of the intestinal epithelium
Microbiome antimicrobial weaponisation approaches using quorum
sensing secondary metabolite signalling
Multifactorial pathways analysis of environmental, behavioural and
genetic risk factors of cancer
Exploring the molecular mechanisms of AID regulation in live cells
and with single molecule resolution
Investigate the shared role of inflammation in cardiovascular
disease and cancer aetiology
Insights into infection from dynamic analysis of bacterial
transcriptomes