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Chapter 13 - Dr. Jennifer Capers
Chapter 13 - Dr. Jennifer Capers

Immune-system-powerpoint
Immune-system-powerpoint

... • InTerferons – chemicals secreted by virus-infected cells that stimulate neighboring cells to produce defensive proteins • Complement – group of proteins that attract phagocytes to foreign cells and cause cell lysis • Histamines are secreted by basophils and lead to the INFLAMMATORY RESPONSE (redne ...
Fall 2004 - Antelope Valley College
Fall 2004 - Antelope Valley College

... The class of antibody first stimulated upon encounter with an antigen is ____________________________. ...
The objectives of this course
The objectives of this course

... Lymphocytes recognizing ubiquitous self-antigens are eliminated p byy a pprocess called "clonal deletion",, leadingg to duringg development "self-tolerance". A lymphocyte y p y needs to meet its antigen g before it can get g activated and start producing identical daughter cells, a process called "c ...
Immunity - CIE Alevel notes!
Immunity - CIE Alevel notes!

... o Neutralise toxins (poisonous chemicals) produced by pathogens; o Prevents bacteria from sticking to body tissues; o Bind to viruses and prevent them infecting cells. ...
The Immune System - Mercer Island School District
The Immune System - Mercer Island School District

... Types: Neutrophils, basophils, eosinophils, lymphocytes, monocytes, and macrophages. Neutrophils fight off bacterial or fungal infections, acting as the first responders. Basophils are responsible for allergic and antigen response by releasing a chemical histamine. Eosinophils are mainly responsible ...
Regents Biology Jonas Salk Developed first vaccine against polio
Regents Biology Jonas Salk Developed first vaccine against polio

The Immune System
The Immune System

... • I need for you to create a concept map using the following terminology and others that you may have learned: immune system, lymphatic vessels, lymph nodes, filter, lymph, B cells, lymphocytes, epitopes, Class II MHC receptor, phagocytes, spleen, ...
The Immune System and Disease
The Immune System and Disease

... vi. mucus, saliva, sweat, and tears contain ______________ that breaks down bacterial cell walls ...
(AIDS) is a disease of the human immune system caused by the
(AIDS) is a disease of the human immune system caused by the

... that sweep away airborne invaders, and tears, secretions, and saliva whose enzymes can destroy bacteria and other pathogens. When this first line of defense fails to prevent an invader from entering the human body, a more specific set of responses can be evoked. The adaptive immune system mounts a s ...
35-2 Defense Against Infection Worksheet
35-2 Defense Against Infection Worksheet

T-cell Recognition/Antigen presentation
T-cell Recognition/Antigen presentation

Typical violations of immunobiological supervision 1. The main
Typical violations of immunobiological supervision 1. The main

... 1. The main target of HIV are: a) lymphocytes; b) T-killer lymphocytes; + c) T-helper lymphocytes; d) NK-cells. 2. Specify the correct statement: a) receptor for the HIV virus infection is a molecule of CD4; b) when HIV infection population of T-helper lymphocytes is depleted; c) when HIV anti-infec ...
The Immune System - Ms. Lin`s Science Class
The Immune System - Ms. Lin`s Science Class

... scissors! Oh no! The scissors are loaded with germs! The germs have clearly gotten past your first line of defense. Describe your body’s second line of defense in a comic book style format. Include pictures and descriptions. ...
Lec.2 Dr.Maysem M.Alwash Hypersensitivity Reaction s (cont.)
Lec.2 Dr.Maysem M.Alwash Hypersensitivity Reaction s (cont.)

Transplantation immunity
Transplantation immunity

exam bullet points
exam bullet points

... Where lymphocytes destroy myelin sheaths of nerves Causing a progressive loss of nerve function Arthritis is an auto immune disease Where lymphocytes attack cartilage at joints Causing bone friction/joint swelling and loss of mobility Auto-immune diseases prevented usually because lymphocytes capabl ...
Immune System Overview
Immune System Overview

... In its four forms, provides the majority of antibody-based immunity against invading pathogens. The only antibody capable of crossing the placenta to give passive immunity to fetus. Expressed on the surface of B cells and in a secreted form with very high avidity. Eliminates pathogens in the early s ...
The humoral immune response defends against pathogens that are
The humoral immune response defends against pathogens that are

... antigen whenever it is encountered. The binding can fight infection in several ways. Antibodies can bind to viruses or bacteria, which interferes with the chemical interactions required for them to infect or bind to other cells. The antibodies may create bridges between different particles containin ...
doc 3.2.4 immunity notes Student notes for section 3.2.4
doc 3.2.4 immunity notes Student notes for section 3.2.4

Document
Document

... E. enchances immunologic cross-reactivity. 42. An antibody made against the antigen tetanus toxoid (TT) reacts with it even when the TT is denatured by disrupting all disulfide bonds. Another antibody against TT fails to react when the TT is similarly denatured. The most likely explanation can be st ...
1. dia
1. dia

... Normal tissue cells do not express MHC class II NO SIGNAL 1. for CD4+ Th activation Normal tissue cells do not express co-stimulatory molecules and do not produce T cell differentiating cytokines NO SIGNAL 2. for CD4+ Th activation Migration of naive T lymphocytes to normal tissues is limited Antige ...
Dental Microbiology #211 IMMUNOLOGY Lecture 1
Dental Microbiology #211 IMMUNOLOGY Lecture 1

... The notion of specificity can be explained in both chemical and geometric terms. Each antibody (Ab) molecule is specific for, and can interact only with one antigen (Ag) specificity. Eg: Ab produced in response to influenza virus type A will protect the host against the influenza A, but not against ...
infection and microbial pathogenecity (host microbe
infection and microbial pathogenecity (host microbe

... Complement mediated lyses ...
Immune Practice Test
Immune Practice Test

... kill infected cells. b) kill pathogen. c) stop the pathogen from spreading. d) create immune memory. e) create antibodies a) ...
< 1 ... 487 488 489 490 491 492 493 494 495 ... 523 >

Cancer immunotherapy



Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.
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