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The Human Immune System - Dakota Hills Middle School
The Human Immune System - Dakota Hills Middle School

File - Classes with Mrs. Sheetz
File - Classes with Mrs. Sheetz

... • Responds in a generic way • Inflammatory response occurs • Histamine: a chemical which initiates the inflammatory response; causes blood vessels to dilate, increases blood flow to area • Phagocytes (macrophages & neutrophils): engulf and remove pathogens ...
PowerPoint **
PowerPoint **

... Pyroptosis---a highly inflammatory form of cell death that lures more CD4 T cells to the area, thereby creating a vicious cycle that ultimately wreaks havoc on the immune system. IFI16, which is known to be part of the protein complex that initiates inflammatory immune responses. An existing caspas ...
Adaptive Immune System
Adaptive Immune System

... cytidine deaminase (AID) increases variableregion diversity on the antibody. ...
345.1 Salcedo - Advances in Neuroblastoma Research
345.1 Salcedo - Advances in Neuroblastoma Research

08 Human immune system
08 Human immune system

... • T-lymphocytes (grow up in thymus) • B-lymphocytes (grow up in bone marrow) • Each one has receptors for a specific antigen • Recognize millions of different antigens! • Diversity generated by: • rearrangement of antigen receptor genes • different joining of the gene segments • Gene rearrangement s ...
THE IMMUNE SYSTEM DEFENSES AGAINST INFECTION Pathogens
THE IMMUNE SYSTEM DEFENSES AGAINST INFECTION Pathogens

... For the immune system to work the body needs to the difference between itself (own cells and materials) and nonself (foreign cells and materials) This recognition is based on differences in certain large molecules (proteins) between one organism and another. When the body recognizes that a cell is a ...
The_Specific_Immune_Response
The_Specific_Immune_Response

... Your lymphocytes with the complementary antibody may come into contact with this antigen in one of three ways: - By encountering the pathogen itself - By your macrophages engulfing the pathogen, then presenting the antigen on their surface - By the pathogen infecting your body cells, and your body c ...
Hadassah University Hospital
Hadassah University Hospital

... COMPOSED OF TWO COMPONENTS ...
9.2 Types of Antibodies and Vaccines ppt
9.2 Types of Antibodies and Vaccines ppt

... 1. IgG: Helps fight bacteria, viruses and toxins. Activates complement. 2. IgA: Found in exocrine excretions to fight particles in tears, stomach juices, bile and urine. 3. IgM: Recognize food and bacteria antigens in the blood. Activates complement. Helps agglutinate or clump antigens. 4. IgD: Foun ...
TUTORIAL 4 Multiple Choices For each of the questions below
TUTORIAL 4 Multiple Choices For each of the questions below

File
File

... The 1918 Spanish flu pandemic that killed lots of people (50 -100 million) worldwide was also caused by a vary similar strain of the H1N1 flu virusthus the “ OH CRAP” response by the WHO in 2009 ...
Antibodies
Antibodies

... match the bacterial antigens. The Ags and Abs join. Once the B-cell is linked to an antigen, the B-cell becomes activated and begins to enlarge. This large B-cell divides to form a clone of cells called plasma cells which produces only one type of antibody. These antibodies are poured into the blood ...
Nrsg 407 Disorders of the Immune System
Nrsg 407 Disorders of the Immune System

... • The initial exposure produces no symptoms but sets the stage for exposure, the antigen combines with IGE antibody already present on the surface of mast cells ...
03-Chapter-8-supplement
03-Chapter-8-supplement

... Finlay and McFadden. 2006. Cell. 124:767-782 ...
11.2 Body`s Lines of Defense
11.2 Body`s Lines of Defense

... viruses from entering your body. Includes your skin, cilia and mucus, stomach acids, and secretions like tears, saliva and sweat. ...
autoimmunity
autoimmunity

... •Skin disease •Proteinuria (leakage of protein into urine) •Massive T cell accumulation ...
Hygiene III The Hugiene Hypothesis
Hygiene III The Hugiene Hypothesis

... – Each produces a different receptor in the cell membrane – Each receptor is composed of 1 molecule each of two different proteins – Each receptor binds a specific antigen but has only one binding site – Receptor only recognizes antigens which are "presented" to it within another membrane protein of ...
The Immune Response - hrsbstaff.ednet.ns.ca
The Immune Response - hrsbstaff.ednet.ns.ca

...  Step 8: During the immune response, memory B cells and memory T cells are created. These cells contain a blueprint of the invader’s antigen. ...
The Immune Response - hrsbstaff.ednet.ns.ca
The Immune Response - hrsbstaff.ednet.ns.ca

...  Step 8: During the immune response, memory B cells and memory T cells are created. These cells contain a blueprint of the invader’s antigen. ...
Cancer Immunology - Roswell Park Cancer Institute
Cancer Immunology - Roswell Park Cancer Institute

Ovplyvnenie imunitnej odpovede
Ovplyvnenie imunitnej odpovede

... application of water extractes of alergen during weaks and months in increasing quantities. Aim – reduction of alergic reaction, increase of inflamation reaction, inhibition of chronical process repeated application with alternative application – production of IgG that will bind antigen before it is ...
Document
Document

... 1. Structure and function of the immune system. Immune system’s cells morphology. 2. Adoptive and aquired immunity. Acquired or congenital defects of phagocytosis. Deficiencies of opsonins, chemotactic abilities, myeloperoxidase, and lysosomal enzyme activation. 3. Complement system. Classical pathw ...
this PDF file
this PDF file

... HIV/AIDS and cancer co-existence both in vivo and in vitro in a cancerimmune environment leads to specific cytokines being produced by various immune cells and the cancer cells. Most of the studies have suggested that specific cytokines produced by the immune system cells and the tumor play an impor ...
File - Mr. Shanks` Class
File - Mr. Shanks` Class

... 1a. several types of leukocytes (white blood cells) that attack and eliminate anything they recognize asforeign. b. macrophages will engulf or eat the invading cells ...
< 1 ... 491 492 493 494 495 496 497 498 499 ... 523 >

Cancer immunotherapy



Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.
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