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AP Biology
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Chapter 11 DNA STRUCTURE Guided Reading Assignment
1. What scientist explained the concept of transformation in detail. Summarize how he did this.
2. Why was the work of Avery, MacLeod and McCarty practically ignored in 1944? p. 235
3. What is a bacteriophage? How was is used in the experiment below?
4.
Label the diagram below and explain the Hershey Chase experiment.
5. How did Chargraff’s work contribute to understanding the structure of DNA?
6. Why was Rosalind’s Franklin’s work essential to the understanding of the structure of DNA?
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7. Label the structures below: include Nucleotide, phosphate, nitrogen base, deoxyribose, double
helix, sugar-phosphate backbone, complimentary bases, purine, and pyrimidine, adenine,
thymine, cytosine and guanine.
8. Why does adenine always pair with thymine and guanine with cytosine in DNA?
9. What is meant by the term that DNA replication is semiconservative?
10. How is bacterial DNA replication accomplished? (small circular chromosomes)
11. What are DNA polymerases?
12. In your own words, what is meant by the phrase – DNA is antiparallel in arrangement”?
13. Describe the following terms:
a. Leading strand
b. Lagging strand
c. Okazaki fragments
d. Primer
e. DNA ligase
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14.
Identify and Label the diagram below: leading strand, lagging strand, DNA Polymerase I, II and
III, helicase, Okazaki fragments, RNA primer, RNA primase, ligase. You may need to add
structures.
15. List the functions of the following enzymes:
a. Helicase
b. Single stranded binding protein
c. Topoisomerase
d. Primase
e. DNA Polymerase III
f. DNA Polymerase II
g. DNA Polymerase I
h. DNA Ligase
16. What is mismatch repair?
17. Why is there a short section of a cell’s DNA that cannot be repaired or replaced? Draw your own
diagram explaining the problem.
18. What are telomeres and why are they important? How does telomerase play a role?
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