Download Faculty of Science Department of science Chemistry of

Faculty of Science
Department of
science
Time of lectures:
Instructor:
Office hours:
2015/2016
Semester:
Chemistry of
Biomolecules
‫كيمياء الجزيئات الحيوية‬
111111
Prerequisite (s):111212
Lecture room (s) :
1st
Text books & References:
Text Book
1. Organic Chemistry, Solomons
Other
2. Organic Chemistry, Morrison and Boyd
References
3. Biochemistry, Streyer
Course Description:
Course outline:
Week Topic detailes
1.
Stereochemistry (3)
Stereoselective and stereospecific reactions, pro-chiral centers and faces,
enantioselectivity and diastereoselectivity.
2.
■ Carbohydrates (1)
Definition and chemical composition. Importance and occurance.
3.
Monosaccharides (4)
Monosaccharide structures and stereochemistry. Aldoses and ketoses.
Nomenclature. Fischer projection formula. Cyclic hemiacetal formation.
Hawarth formula. Furanoses and pyranoses. The anomeric effect. Reactions
and methods of synthesis.
4.
■Di- and Polysaccharides (4)
The Glycosidic linkage. Reducing and nonreducing sugars. Synthesis of
glycosides. Identification and structure determination (sequencing) of
polysaccharides by enzymetic and by chemical methods. Examples of some
common disaccharides and polysaccharides. Chemically modified cellulose.
5.
■Amino acids (4)
physical Properties. Isoelectric point and effect of pH. Chemical properties
and reactions. Synthesis of α-amino acids.
6.
■Proteins (6)
The peptide bond. Examples of biologically important oligopeptides. Types,
structure, and biological function of proteins. Synthetic methods for peptides
and polypeptides. Methods of Sequencing of polypeptides and proteins.
■Lipids- Fats and Oils (4)
Classification of fats. Types of fatty acids. Saturated and unsaturated fats.
Effect of unsaturation on physical and chemical properties and the biological
consequences. Industrial uses of fatty acids. Phospholipids, sphingolipids,
waxes.
■Lipids- Steroids, Prostaglandins, and Terpenes (4)
Types and structural differences of prostaglandins. Biological function. Types
of steroids. Biological functions. Structure and stereochemical aspects related
to the steroid ring system. Examples of some chemical transformations with
emphasis on Regio- and stereoselectivity.
■Nucleic acids (6)
Structure of nucleic acids DNA and RNA. Biological function in relation to
structure. Nucleosides and nucleotides. Transcription and protein synthesis.
Synthesis of nucleosides and nucleotides. Sequencing with chemical and
enzymetic methods. Genetic engineering.
Attendance Policies:
 Be Punctual.
 Attendance is mandatory. Students are not allowed to miss more than 15% of the
lectures, without acceptable real cause.

If a student misses more that 15 % of the course lectures, she/he will forfeit the course
credits. After this, medical reports may be submitted for evaluation, for a total absence
of no more than 20%. If student misses more than 20% of lectures, regardless of the
cause, the course will be failed.
Grading system:
Assessment
First Exam
Second Exam
Activities and Evaluation
Final Examination
Total
Grade
25%
25%
10%
40%
100%