Download CHARLES E. ROGLER, Ph.D. Positions: Research interests:

CHARLES E. ROGLER, Ph.D.
Positions:
Professor, Departments of Medicines (Gastroenterology & Liver Diseases), of Microbiology &
Immunology and of Genetics, Albert Einstein College of Medicine
Research interests:
Dr. Rogler’s laboratory currently focuses on the role of miRNAs and long noncoding RNAs in hepatocarcinogenesis and liver stem cell differentiation. He has been interested in liver stem cells since the 1980s,
when he was one of the first to appreciate the role of liver stem cells called “oval cells“ in hepatocarcinogenesis. The laboratory has used an elegant triple staining protocol to identify hepatocytic and bile
ductular lineages extending from a common stem cell precursor in cirrhotic human liver. In collaboration
with the Leslie E. Rogler laboratory, they have generated chimeric mice with the marked liver stem cell
line and traced the fate of the cells in chimeric mice. These studies clearly demonstrated that the liver
stem cells maintained their liver specification in the chimeric mice. Recent studies have investigated the
role of miRNAs in hepatocarcinogenesis and liver stem cell differentiation. His laboratory has identified
miR-21 and the miR 17-92 polycistron as important in hepatocarcinogenesis. miR-21 is highly upregulated in HCC and promotes a metastatic phenotype of HCC by directly targeting the tumor-suppressor
gene, RHOB. Further studies in fetal liver development showed that the miR-23b polycistron was upregulated during fetal liver development and regulated the differentiation of liver stem cells through Smads
3, 4 and 5 and by blocking the TGFb pathway.
Current grant funding:
5 RO1 CA 37232-29 (Rogler)
NIH, NCI
04/01/2007–3/31/2012; No-cost extension until 3/31/13
Hepadnavirus associated hepatocellular carcinoma
NYSTEM NO8G-374 (Rogler)
01/01/2009–12/ 31/2012
Roles of miRNAs in hepatic stem cell differentiation
5 P30 DK 41296-23 (Rogler)
NIH, NIDDK
06/01/2009–05/31/2014
Liver Pathobiology and Gene Therapy Research Core Center
Five recent publications:
1. Zhou HC, Rogler LE, Tepperman L, Morgan G, Rogler CE. Identification of
hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions
in cirrhotic human liver. Hepatology 2007, 45:716–24, PubMed PMID: 1732614.
2. Rogler CE, Zhou HC, LeVoci L, Rogler CE. Clonal, cultured, murine fetal liver
hepatoblasts maintain their liver specification in chimeric mice. Hepatology 2007, 46:1971–8,
PubMed PMID: 17935221.
3.
Connolly E, Melegari M, Landgraf P, Tchaikovskaya T, Tennant BC, Slagle BL, Rogler L,
Zavolan M, Tuschl T, Rogler CE. Elevated expression of the miR-17-92 polycistron and
miR-21 in hepatocellular carcinoma contributes to the malignant phenotype. Am. J. Pathol. 2008,
173:856–64: DOI: 10.2353/ajpath.2008.080096. PubMed Central PMCID: PMC2527078.
4. Rogler CE, Levoci L, Tchaikovskaya T, Rogler LE. MiR-23b cluster miRNAs regulate
TGFb/BMP signaling and differentiation of liver stem cells by targeting Smads. Hepatology 2009,
50:575–84, PubMed PMID: 19582816.
5. Connolly EC, Van Doorslaer K, Rogler L, Rogler CE. Over-expression of micoRNA-21 promotes a
metastatic phenotype by targeting the tumor suppressor RHOB. Molecular Cancer Res. 2010,
8:691–700. PubMed PMID: 20460403.