Download PDF File - UK Biobank

Applicant PI: Dr Andrew McQuillin
Applicant Institution: University College London, Division of Psychiatry, Rockefeller
Building, 21 University Street, London, WC1E 6BT, United Kingdom
Application Number / Title: 20737 - The influence of genetics and alcohol
consumption on health and social outcomes
Lead Collaborators: 1) Dr Stephen Atkinson
Collaborating Institutions and Addresses: 1) Imperial College London, Hepatology,
Liver Unit, 10th Floor QEQM, St Marys Hospital, Praed Street, London, W2 1NY
Keywords provided by the Applicant PI to describe the research project: Alcohol,
liver, cognition
Application Lay Summary:
1a: Environmental risk factors including unsafe alcohol consumption and other drug
use are risk factors for a variety of poor physical and mental health outcomes such as
psychosis, alcoholic liver disease and Wernicke-Korsakoff syndrome. The purpose of
the proposal is to investigate how these factors combined with measures of genetic
risk affect these important health outcomes in the UK Biobank data.
1b: The purpose is to understand how the effects of environmental factors such as
alcohol consumption impact a variety of physical and mental health outcomes.
Improved understanding of these outcomes will provide important new data for
potential use in public health interventions.
1c: The research will use environmental measures such as alcohol consumption
combined with genetic, social and health outcome data to study the interaction of
these risk factors in determining their impact on physical and mental health. One of
our aims is to examine whether certain risk factors have a disproportionate effect on
health outcome measures in different groups of individuals.
1d: The full cohort will be required because we will wish to study the impact of
alcohol use and other environmental risk factors on disease outcome in both a
categorical and quantitative manner.