DNA: THE SECRET OF By: James Watson LIFE Reading Reflections: Chapter 1 and 2 Introduction to Molecular Genetics Chapter 1: Beginnings of Genetics: From Mendel to Hitler • DNA is the molecule of Inheritance, but we did not always know this fact. • Inheritance is easy to observe Charles II - Hapsberg lip Mendel studied inheritance but had no idea that DNA was responsible. Some Review •Genome - full set of an organisms DNA • About 3 billion for humans • We have two sets – Why? How? •Genes - sections of DNA that code for proteins • About 20,000 genes for humans •Chromosomes - Subsections of the genome • 23 pairs for humans Some Review: Central Dogma of Biology genotype phenotype Role of Environment! Nature vs. Nurture • Above spectrum attempts to explain approaches to understand human behavior/thinking (Psychology). Schizophrenia – some data What do these data imply about the nature v. nurture relationship for schizophrenia? (Source: Gottesman, 1991) Back to Review: Evolutionary by Natural Selection Darwin did not know about DNA either!! Artificial Selection • “..in fact the single greatest application of genetics to human well-being was carried out eons ago by anonymous ancient farmers.” (Watson) ~12,000 years ago in the fertile crescent What are the connections to the Eugenics Movement here? Some crazy and scary eugenics pedigrees Some crazy and scary eugenics pedigrees Some crazy and scary eugenics pedigrees Some crazy and scary eugenics pedigrees Chapter 2: The Double Helix • Biology before the discovery of DNA • Naturalists • Anatomists • Chemists DNA Reading Reflection • Chapter 1 • Pick one event or person from this chapter that surprised you. • Write about the historical and scientific entanglements of this person or event. • In your opinion. What was good or bad about the person/event? • Chapter 2 • Pick one person (or group of people) from this chapter and describe their contribution to our understanding of DNA. • Include how this person was influenced by other researchers.