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APh161 - Lecture 11: The Cytoskeleton is Always Under Construction Mullins et al. Rob Phillips California Institute of Technology The Hierarchy of Time Scales Time Dependence of Gene Expression Collins et al. Elowitz et al. Rate Equations and Genetic Circuits The Rate Equation World View Wong, Gladney, and Keasling ‘03 Vilar and Leibler ‘03 Putting the Stopwatch on Cell Motility http://cmgm.stanford.edu/theriot/movies.htm - the place to be! Courtesy of Julie Theriot et al., Stanford The Eukaryotic Cell Cycle Adapted from Pollard and Earnshaw Cytoskeletal Action During Cell Division Cytoskeleton Mediated Mitosis Show the movies in the Lecture 11 directory – see http://www.bio.unc.edu/faculty/salmon/lab/mitosis/mitosismovies.html Cell Division in Bacteria Petra Levin FtsZ rings during division Polymerization Processes 1: Tobacco Mosaic Virus Caspar Dynamics of Molecular Motors Science, Vol 300, Issue 5628, 2061-2065, 27 June 2003 - Yildiz et al. Rate Equations: Decay Processes Rate Equations: Sum Over Trajectories Rate Equations: Birthing Reactions A reminder on the cytoskeleton Actin, Microtubules, Intermediate Filaments Actin Polymerization Rate in vitro ParM Length Distribution Mullins et al., Science 2004 Actin and its Partners Microtubule Dynamics: Part of the Polymerization Puzzle Microtubule Dynamics In Vitro Show Borisy movies, http://www.borisylab.nwu.edu/pages/supplemental/treadmill.html Life at the Leading Edge The Story of ParM (Dyche Mullins et al.)