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Welcome to Molecular Biology Through Discovery Tuesday, 4 September 2012 Wrinch: Structure of Chromosomes / Protein Welcome to Molecular Biology Through Discovery Tuesday, 4 September 2012 Wrinch: Structure of Chromosomes / Protein What do we talk about? Determined by Questionnaires Your Questions Just to make sure I'm clear we're not submitting the SQ questions that we answered for review correct? we don't have to send in all the answers to the question on each reading right? Just the questions set on the problem sets? Remind me about what we were suppose to do with the group assignment. Wrinch (1936) – What is a Gene? Explaining what did they think back in 1936 compared to now day's thoughts Wrinch (1936) – What is a Gene? What are genes?... There is no consensus of opinion amongst geneticists as to what the genes are – whether they are real or purely fictitious – because at the level at which the genetic experiments lie, it does not make the slightest difference… Thomas Morgan Nobel Lecture (1934) Wrinch (1936) – What is a Gene? Drosophila chromosome The constancy of position of genes with respect to other genes in linear order in the chromosomes is deducible, both from genetic evidence and from cytological observations. Morgan T (1934) Nobel Lecture Wrinch (1936) – What is a Gene? Wrinch (1936) – What is a Gene? Dorothy Wrinch Wrinch (1936) – What is a Gene? Could we perhaps go over a little more of how she visualized genes in her chromosome micelle model? Dorothy Wrinch Wrinch (1936) – What is a Gene? Dorothy Wrinch Wrinch (1936) – What is a Gene? Dorothy Wrinch Wrinch (1936) – What is a Gene? Dorothy Wrinch Wrinch (1936) – What is a Gene? Dorothy Wrinch Wrinch (1936) – What is a Gene? Dorothy Wrinch Wrinch (1936) – What is a Gene? Dorothy Wrinch Wrinch (1936) – What is a Gene? Dorothy Wrinch Protein …structural levels of proteins, for some reason I was under the impression that every protein consisted of all of the structures Protein Different levels of protein structure 1. Enumeration 2. Local interaction 3. Distant interaction 4. Interaction between subunits Primary Structure Protein Different levels of protein structure 1. Enumeration Primary Structure 2. Local interaction Secondary Structure 3. Distant interaction 4. Interaction between subunits Protein Different levels of protein structure 1. Enumeration Primary Structure 2. Local interaction Secondary Structure 3. Distant interaction Tertiary Structure 4. Interaction between subunits Protein Different levels of protein structure 1. Enumeration Primary Structure 2. Local interaction Secondary Structure 3. Distant interaction Tertiary Structure 4. Interaction between Quaternary Structure subunits Protein Different levels of protein structure Compare hemoglobin myoglobin Protein …structural levels of proteins, for some reason I was under the impression that every protein consisted of all of the structures Primary per definition Secondary optional Tertiary per definition Quaternary optional Annotation Critique annotation T4p018 T4p039 T4p042 T4p120 How to Annotate Genes Coming Attractions Coming Attractions Coming Attractions Coming Attractions Coming Attractions I think the most challenging part of this process is finding evidence the most helpful thing to go over in class would be how to find evidence to justify an annotation. How to Annotate Genes Study Question 13 How did glycophorin A gain its proper position in the red blood cell membrane. Study Question 13 How did glycophorin A gain its proper position in the red blood cell membrane. How does protein get inside? Study Question 13 How did glycophorin A gain its proper position in the red blood cell membrane. Study Question 13 How did glycophorin A gain its proper position in the red blood cell membrane. Study Question 13 How did glycophorin A gain its proper position in the red blood cell membrane. Goodbye from Molecular Biology Through Discovery Tuesday, 4 September 2012