* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Lupus Erythematosis - University of California, Irvine
Infection control wikipedia , lookup
Cancer immunotherapy wikipedia , lookup
Periodontal disease wikipedia , lookup
Kawasaki disease wikipedia , lookup
Globalization and disease wikipedia , lookup
Polyclonal B cell response wikipedia , lookup
Hospital-acquired infection wikipedia , lookup
Rheumatic fever wikipedia , lookup
Multiple sclerosis research wikipedia , lookup
Guillain–Barré syndrome wikipedia , lookup
Azathioprine wikipedia , lookup
Hygiene hypothesis wikipedia , lookup
Psychoneuroimmunology wikipedia , lookup
Inflammation wikipedia , lookup
African trypanosomiasis wikipedia , lookup
Plasmodium falciparum wikipedia , lookup
Neonatal infection wikipedia , lookup
Systemic scleroderma wikipedia , lookup
Neuromyelitis optica wikipedia , lookup
Schistosomiasis wikipedia , lookup
Ankylosing spondylitis wikipedia , lookup
Monoclonal antibody wikipedia , lookup
Autoimmunity wikipedia , lookup
Anti-nuclear antibody wikipedia , lookup
Sjögren syndrome wikipedia , lookup
Immunosuppressive drug wikipedia , lookup
Autoimmune disease › “The great imitator” › Inflammation › Episodic flares Forms › › › › Systemic Cutaneous/Discoid Drug-induced Neonatal Mother-fetus Ab transfer “The wolf” ca. 14th century SOAP BRAIN MD › › › › › › › › › › › Serositis: inflammation of pleura, pericardium and peritoneum Oral ulcers Arthritis Photosensitivity Blood: Blood disorders like anemia, leukopenia, lymphopenia and thrombocytopenia, cardiovascular disease Renal disorder: Leading cause of death in SLE Antinuclear antibodies: Anti-DNA, etc. Immunologic disorder: Syphilis false positive, antiphospholipid syndrome, susceptibility to infection Neurologic Disorder: Can attack nervous system Malar Rash: Butterfly rash on cheeks Discoid Rash: Red, disc-shaped rashes. Discoid Rash Malar or “Butterfly” Rash From RadioGraphics Journal Malar rash Pericarditis Estimated 5 million afflicted globally › 1.5 million in the U.S. › 16,000 new cases each year in the U.S. Risk factors › Genetics ITGAM, BANK1, TLR-7, STAT4, etc. FcγR Iib: Suspected Plasmodium resistance › Ethnicity More prevalent in non-caucasians › Sex More than 90% are female No Cure › Except drug-induced LE Reduce inflammation › Corticosteroids › NSAIDS Antimalarial drugs › Hydroxychloroquine Immunosuppressants › Methotrexate › Azathioprine › Opportunistic Infections? Monoclonal Antibodies › Benlysta®: Inhibit B-lymphocyte Stimulator › Rituxan®: Tag and destroy B-cells › These and others reduce B-cell activity and thus auto- antibodies. Mesenchymal Stem Cell Transplant › Trials to for most severe cases › Reset the immune system The Lupus Foundation of America › www.lupus.org Mayo Clinic: Lupus › http://www.mayoclinic.com/health/lupus/DS00115 Clatworthy et al. Systemic lupus erythematosus-associated defects in the inhibitory receptor FcγRIIb reduce susceptibility to malaria. PNAS. (2007) 104:7169-7174. Yuan YJ, Luo XB, Shen N. Current advances in lupus genetic and genomic studies in Asia. (2010) 19:1374-1383. Liang et al. Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis (2010) 69:1423-1429