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An update on pityriasis rosea and other similar childhood exanthems
An update on pityriasis rosea and other similar childhood exanthems

... obtained with treatment using topical or oral antifungal agents, although recurrence is common. Besides its response to treatment, pityriasis versicolor can be distinguished from pityriasis rosea by its distribution (upper trunk, neck, and face), color (hyperpigmented or hypopigmented rather than er ...
Sarcoidosis - Derm.TheClinics.com
Sarcoidosis - Derm.TheClinics.com

... Japan to have cardiac muscle granulomas [55]. Clinically, however, only 5% of cases have cardiac manifestations [56]. Roberts et al found conduction defects and ventricular arrhythmias to be the most common manifestations in symptomatic patients [2]. Cardiac findings include electrocardiographic abn ...
Pemphigoid diseases: Pathogenesis, diagnosis, and treatment
Pemphigoid diseases: Pathogenesis, diagnosis, and treatment

... recently been reported in Great Britain based on a data registry established on the general practitioner level [6]. Interestingly, in Germany and Great Britain, it has been shown that the incidence of BP has considerably increased within the last 10 years (2-fold and 4.8-fold, respectively) [1,6]. T ...
Potential role of Demodex mites and bacteria in the induction of
Potential role of Demodex mites and bacteria in the induction of

... clinical improvement was noted in patients with rosacea who were administered tetracycline antibiotics, although these antibiotics neither demonstrate activity against D. folliculorum nor reduce their numbers on the skin. It has been suggested that the beneficial activity of antibiotics was due to t ...
Panniculitis Made Simple
Panniculitis Made Simple

... fats in adipose tissue that solidify more rapidly at low temperatures • High mortality rate --> sepsis ...
Psoriasis - UCSF Dermatology
Psoriasis - UCSF Dermatology

...  Remember to address both the physical and psychosocial aspects of psoriasis  Many patients with psoriasis: ...
Facts About Psoriasis - Boehringer Ingelheim
Facts About Psoriasis - Boehringer Ingelheim

... Mild disease can often be managed with topical treatments, whereas people with moderate-to-severe plaque psoriasis may need biologic treatment.11 Biologics are different from traditional systemic drugs that impact the entire immune system. Biologics, instead, target specific parts of the immune syst ...
Autoimmunity to glomerular antigens in
Autoimmunity to glomerular antigens in

... of both conditions [3], transition between syndromes occurs [4] and case reports of simultaneous development of IgA nephropathy or HenochSchoenlein purpura (HSP) within sibships have been documented [5]. This, coupled with the strikingly similar glomerular changes of mesangial proliferation with dif ...
Print - Circulation Research
Print - Circulation Research

... the NADPH oxidase subunit p22phox in the subfornical organ reduces hypertension and T cell activation, while activation of sympathetic outflow by deletion of the extracellular superoxide dismutase in the subfornical organ enhances T cell activation.2, 8, 9 The mechanisms underlying this link between ...
Lee Clinic Dermatology | Dermatologist Cork | Psoriasis
Lee Clinic Dermatology | Dermatologist Cork | Psoriasis

... as they go, finally dying before they are shed from the surface. This process normally takes between 3 and 4 weeks. In psoriasis, the rate of turnover is dramatically increased within the affected skin, so that cells are formed and shed in as little as 3 or 4 days. There is also inflammation and blo ...
The Skin and Hair
The Skin and Hair

... vary from person to person. The ‘classical’ skin problem in lupus is the butterfly rash. This is a red rash, sometimes no more than a mild blush that occurs across the bridge of the nose and on the cheeks resulting in a distinctive butterfly like appearance. This type of rash tends to occur in the s ...
Immune Complex Deposits as a Characteristic Feature of
Immune Complex Deposits as a Characteristic Feature of

... Systemic autoimmune diseases, such as systemic lupus erythematosus (lupus, SLE), rheumatoid arthritis and systemic sclerosis (scleroderma), occur in up to 5-8% of the human population. Based on frequency of occurrence, they are the third most common diseases after cardiovascular pathologies and canc ...
Immunoflourescence in dermatopathology
Immunoflourescence in dermatopathology

... Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). Immunoglobulin deposits, especial ...
Lejupielādēt - Dermatologs
Lejupielādēt - Dermatologs

... resistance, obesity and atherosclerotic diseases. Psoriasis is an inflammatory skin disease related to metabolic syndrome. The aim of this study was to examine the relationship between serum LCN2 levels and indicators for metabolic syndrome and inflammatory cytokine levels in patients with psoriasis ...
Pathophysiology and Clinical Spectrum of Infections in Systemic
Pathophysiology and Clinical Spectrum of Infections in Systemic

... including generation of autoantibodies in low titers with a transient course, but the progression into an established autoimmune disease is rare.64,65 The most common viral infections in patients who have SLE are parvovirus B19 (there are more than 30 reports of primary B19 infection reported as lup ...
misdiagnosed and treated as non-Hodgkin lymphoma
misdiagnosed and treated as non-Hodgkin lymphoma

... and 4). The lymphadenopathy also responded, and after 3 months there were no palpable lymph nodes. At that time, tab methotrexate was stopped due to raised transaminase levels, but the steroids were continued and gradually tapered off in 6 months. After 6 months the oral treatment was stopped and on ...
immunochemical mechanisms involved in penicillin hypersensitivity
immunochemical mechanisms involved in penicillin hypersensitivity

... Carrier specificity toward human serum albumin was indicated in one patient (Levine and Price, 1964), towards human gamma globulin in another (Levine and Ovary, 1961), and to as yet unidentified proteins in others (Levine and Price, 1964). Since skin sensitizing antibodies may mediate some kinds of ...
Cutaneous Lupus Erythematosus
Cutaneous Lupus Erythematosus

... which are directly pathogenic, including dsDNA, and Ro/SSA antibodies.  Lupus patients have reduced clearance of immune complexes by the reticuloendothelial system  Most of the tissue injury is due to B-cells due to immune complex and complement mediated damage through  1. Direct cell death  2. ...
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... Persistent proteinuria is a strong independent risk factor for progression to end-stage chronic kidney disease (CKD) Hypertension and diabetes are the two biggest risk factors for proteinuria Early intervention after detection can prevent/ prolong progression to renal failure ...
Looking Your Best Without Surgery A Skin Rejuvenation Handbook
Looking Your Best Without Surgery A Skin Rejuvenation Handbook

... Treatment of the Eyelids with Thermage, Fraxel, and Fraxel Repair Laser During the past four years, there have been dramatic and revolutionary advances in laser technology. By applying these new technologies to the eyelids, it has become possible to rejuvenate and tighten the eyelid skin in nearly a ...
Prevalence of pruritus in psoriatic skin lesions and its relations to
Prevalence of pruritus in psoriatic skin lesions and its relations to

... among females may be due to iron deficiency. Iron deficiency is very common in our country due to worm infestations, multiple subsequent pregnancies and some other reasons. Although the patients with less than 10g% of Hb were excluded from the study but the Hb percentage in majority of females was l ...
What`s New in Eosinophilic Esophagitis and Proton Pump Inhibitor
What`s New in Eosinophilic Esophagitis and Proton Pump Inhibitor

... Modified from Aceves, Furuta, Spechler. Gastrointest Endosc Clin N Am 2008;18:195 ...
Vitiligo, Depigmentation And Monobenzone
Vitiligo, Depigmentation And Monobenzone

... metabolic acidosis with in 6 hours of skin peeling procedures with phenol.  Different type of lasers are selectively destructive to melanocytes but technique is painful and expensive. Moreover these are more efficient in patients with Koebner Phenomenon (skin lesions which appear at the site of inj ...
- The Journal of Thoracic and Cardiovascular Surgery
- The Journal of Thoracic and Cardiovascular Surgery

... liative operations for congenital heart disease.1-3 All of these palliative procedures share in common the provision of pulmonary arterial blood flow derived from systemic venous blood devoid of hepatic drainage. Further evidence for the role of the liver in the formation of these lesions comes from ...
Z-DNA-specific Antibodies in Human Systemic
Z-DNA-specific Antibodies in Human Systemic

... Medical School, Boston, Massachusetts 02115 A B S T R A C T Naturally occurring antibodies to lefthanded Z-DNA have been shown to be present in the sera of human patients with systemic lupus erythematosus (SLE). These antibodies are of two types. One type reacts with both denatured DNA and Z-DNA. Th ...
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Systemic scleroderma



Systemic sclerosis or systemic scleroderma is an autoimmune or connective tissue disease. It is characterized by thickening of the skin caused by accumulation of collagen, and by injuries to the smallest arteries. There are two overlapping forms. Limited cutaneous scleroderma is limited to the skin on the face, hands and feet. Diffuse cutaneous scleroderma covers more of the skin, and is at risk of progressing to the visceral organs, including the kidneys, heart, lungs and gastrointestinal tract.Survival is determined by the severity of visceral disease. Prognosis is difficult to predict until the disease differentiates into recognizable subsets. Patients with limited cutaneous scleroderma have a good prognosis, with 10-year survival of 75%, although <10% develop pulmonary arterial hypertension after 10 to 20 years. Patients with diffuse cutaneous scleroderma have a 10-year survival of 55%. Death is most often from pulmonary, heart and kidney involvement, although survival has greatly improved with effective treatment for kidney failure. Immunosuppressive drugs are used, although glucocorticoids have limited application.Annual incidence is 19 per million, and prevalence is 19-75 per 100,000, with a female:male ratio of 3:1, and 8:1 in mid to late childbearing years. Incidence is twice as high among African Americans, and the Choctaw Native Americans in Oklahoma have the highest prevalence in the world (469/100,000). There is some hereditary association, some suggestion of immune reaction (molecular mimicry) to a virus, and some cases caused by toxins.
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