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Autoimmune Diseases
Autoimmune Diseases

... » Antibodies to DNA (Classic SLE) » Antibodies to histones (Drug induced SLE) » Antibodies to non- histone proteins bound to RNA » Antibodies to nucleolar antigens ...
Atypical Wound Care
Atypical Wound Care

... • Blueness or redness of fingers and toes in response to heat and cold • Ulcerations on fingertips or toes • Skin hardness / thickening • Skin is abnormally dark or light • Shiny hands and forearm • Small white lumps beneath the skin • Tight and mask-like facial skin ...
Anthrax
Anthrax

... Skin contact – cutaneous, ingestion-gastrointestinal, inhalation-pumonary ...
CASE REPORT CREST SYNDROME AND RENAL INVOLVEMENT
CASE REPORT CREST SYNDROME AND RENAL INVOLVEMENT

... A 66 year-old woman with a history of Raynaud’s phenomenon for 30 years, presented with fingertip calcification and ulceration. She complained of discharge of small stones from these ulcerated lesions for several years and dysphagia in the past year. On physical examination, we noticed mild telangie ...
Autoimmune Disorders
Autoimmune Disorders

... 1. Severe fibroproliferative vascular lesions of small arteries and arterioles, 2. Excessive and often progressive deposition of collagen and other extracellular matrix (ECM) macromolecules in skin and various internal organs ...
Differential diagnosis of scleroderma and pseudoscleroderma
Differential diagnosis of scleroderma and pseudoscleroderma

... consecutive patients with SSc without diffuse skin involvement [4]. In 507 cases, ISSc was diagnosed. In 48 patients typical organ manifestations of SSc were found without skin sclerosis. Of these, 98 % had RP and 93 % a positive ANA titer. These rates do not differ significantly from those of ISSc ...
Connective Tissue Diseases
Connective Tissue Diseases

... sclerosis but usually no vascular or internal organ involvement, juvenile systemic sclerosis: there is diffuse skin sclerosis along with internal organ involvement. ...
Scleroderma and the Kidney
Scleroderma and the Kidney

... precursors ie CD34+, CD133+ and VEGF type 2 – Pts with SSc have incr in endothelial cell surface expression of adhesion molecules and elevation in circulating levels of their soluble forms. Cytokine induced upregulation of adhesion molecules ie ICAM-1, VCAM-1, ELAM-1 ...
Immunology Stack - U
Immunology Stack - U

... lacrimal glands. Formation of germinal centers is possible. ...
Systemic Sclerosis
Systemic Sclerosis

... disease characterized by fibrosis and vasculopathy of skin and visceral organs ...
< 1 ... 5 6 7 8 9

Systemic scleroderma



Systemic sclerosis or systemic scleroderma is an autoimmune or connective tissue disease. It is characterized by thickening of the skin caused by accumulation of collagen, and by injuries to the smallest arteries. There are two overlapping forms. Limited cutaneous scleroderma is limited to the skin on the face, hands and feet. Diffuse cutaneous scleroderma covers more of the skin, and is at risk of progressing to the visceral organs, including the kidneys, heart, lungs and gastrointestinal tract.Survival is determined by the severity of visceral disease. Prognosis is difficult to predict until the disease differentiates into recognizable subsets. Patients with limited cutaneous scleroderma have a good prognosis, with 10-year survival of 75%, although <10% develop pulmonary arterial hypertension after 10 to 20 years. Patients with diffuse cutaneous scleroderma have a 10-year survival of 55%. Death is most often from pulmonary, heart and kidney involvement, although survival has greatly improved with effective treatment for kidney failure. Immunosuppressive drugs are used, although glucocorticoids have limited application.Annual incidence is 19 per million, and prevalence is 19-75 per 100,000, with a female:male ratio of 3:1, and 8:1 in mid to late childbearing years. Incidence is twice as high among African Americans, and the Choctaw Native Americans in Oklahoma have the highest prevalence in the world (469/100,000). There is some hereditary association, some suggestion of immune reaction (molecular mimicry) to a virus, and some cases caused by toxins.
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