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1. Scleredema
1. Scleredema

... Stiffness occurs in the skin, especially of the face, neck, shoulders, upper back, and in some cases the upper extremities and trunk (Fig. 17.5). The distal portions of the extremities are not involved. The induration is non-pitting and hard. It is asymptomatic at the early stages; however, mild mob ...
Multiple cutaneous reticulohistiocytomas in a patient with
Multiple cutaneous reticulohistiocytomas in a patient with

... Multicentric reticulohistiocytosis (MR) and multiple cutaneous reticulohistiocytomas (MCR) are rare granulomatous idiopathic disorders included in the reticulohistiocytosis spectrum [1, 2]. The reticulohistiocytoma is the primary skin lesion for both these diseases, and it usually presents as a firm ...
Scalp Erosion Taking AEC and EEC Research to the Next Level
Scalp Erosion Taking AEC and EEC Research to the Next Level

... In addition, we plan to use the iPSC-derived skin cells (either with or without p63 mutation) to answer mechanistic questions about p63. Examples of questions we aim to answer are: Why do certain mutations in p63 cause AEC whereas others cause EEC? Why do some EEC mutations cause skin erosions and o ...
Ultra Skin Needling Information Ultra Skin Needling is a
Ultra Skin Needling Information Ultra Skin Needling is a

... Vitamin A and C are essential for collagen production and sun damage reversal. It is impossible to achieve high concentrations of vitamin C or A in the skin by taking tablets orally. Therefore you will be recommended to use skin care products at home that contain high concentrations of these vitamin ...
Complications of Atopic Dermatitis
Complications of Atopic Dermatitis

... Generally begins in the first year of life, with 60% of patients developing symptoms in the first year with 85% of patients developing symptoms by age 5. Earlier onset is associated with a more severe course, as is atopic dermatitis in an infant affecting the flexural areas of elbows and knees. Many ...
Treatment of Schamberg`s disease with pentoxifylline
Treatment of Schamberg`s disease with pentoxifylline

... (>50%). Marked improvement was observed in 15/30 (50%) patients. We conclude that pentoxifylline should be considered as first line therapy in all patients with Schamberg's disease. Keywords Schamberg’s disease, pentoxifylline ...
L1 Nephritis 2013
L1 Nephritis 2013

... - RPGN is a clinical syndrome and not a specific form of GN - 50% decline in the glomerular filtration rate (GFR) with in 3 months if left untreated death may occur in months due to acute renal failure - In most cases the glomerular injury is immunologically mediated - A practical classification di ...
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus

... Most patients (85-90% never develop systemic lupus) ...
A recalcitrant case of cicatricial pemphigoid
A recalcitrant case of cicatricial pemphigoid

... cyclophosphamide, and IVIg, she developed further surfaces and the skin. Therefore, it is crucial that a conjunctival adhesions and severe oral and pharyngeal multidisciplinary team including a dermatologist, mucosal ulcerations causing pain, dysphagia, and ophthalmologist, otolaryngologist, and gas ...
AUTOIMMUNE DISEASES Systemic VS Organ
AUTOIMMUNE DISEASES Systemic VS Organ

... autoimmune diseases. What are Autoimmune Diseases? Autoimmune disease is a term that encompasses more than one hundred distinct disorders that originate in the immune system. The immune system is a network of organs and cells, including the bone marrow, white blood cells, tonsils, and spleen, which ...
Glomerulonephritis
Glomerulonephritis

... – Other glomerular disease (IgA) – Other renal disease (chronic reflux / pyelonephritis / interstitial nephritis) – Systemic disorder (HIV) – Drugs (Heroin) ...
here - UK TREND
here - UK TREND

... primary melanoma to metastatic melanoma in the same individual? What biomarkers or patient or tumour characteristics predict which actinic keratosis will progress to SCC? What factors drive the survival of melanoma cells that are apparently dormant and that lead to metastases, in some cases, decades ...
HERE - Conners Clinic
HERE - Conners Clinic

... which is associated with asthma or hay fever and a familial occurrence of these conditions. The disease comes in attacks that seem to get better then worse in cycles. There are a number of different eczemas – rashes which cause the skin to become inflamed and itchy. AD is also called 'atopic eczema' ...
Autoimmunity and pulmonary hypertension: a perspective REVIEW
Autoimmunity and pulmonary hypertension: a perspective REVIEW

... The answer to this question may come from the increasing body of evidence concerned with the central importance of regulatory T-cells in preventing inappropriate B-cell activity. Two striking similarities between conditions associated with severe angioproliferative pulmonary hypertension are a defec ...
SAQ of Dermatology for MBBS Students
SAQ of Dermatology for MBBS Students

... Systemic Ivermactin ...
VIEW PDF - Practical Dermatology
VIEW PDF - Practical Dermatology

... According to Dr. Weiss, the process is relatively straightforward. The area behind the ear is anesthetized with lidocaine before 23mm punch biopsies are taken. The biopsy materials are placed in a transport medium and then shipped out for processing. The roughly six-week processing technique purifie ...
Module 3 - 11.32 MB
Module 3 - 11.32 MB

... • Mild topical corticosteroids useful for acute forms (1% to 2% hydrocortisone) • Once controlled, maintenance with medicated shampoos that act against yeast, eg, selenium sulfide, ketoconazole, tar shampoos ...
University of Groningen Systemic inflammation and monocyte
University of Groningen Systemic inflammation and monocyte

... perform when epidural cocaine was available for the blocking of nerve trunks (5). Although surgery could now be practised without pain, surgery related mortality was still high due to blood loss and postoperative infection. In 1848, Semmelweis reported that fever and septicaemia in pregnant women co ...
The Current Role of Hematopoietic Stem Cell Transplant
The Current Role of Hematopoietic Stem Cell Transplant

... most common form of PI. Typically, CVID patients are treated with IG therapy for life because, in most cases, it is effective in maintaining sufficient antibody levels to protect from infection and any complications. However, those with CVID have a 20 percent to 30 percent chance of developing autoi ...
Tinea Versicolor - Rutland Skin Center
Tinea Versicolor - Rutland Skin Center

... Perlèche, also known as angular cheilitis, is a mild rash at the corners of the mouth, usually caused by moisture that often becomes infected by yeast, and or bacteria. Patients with diabetes, dentures, or who drool may be at increased risk for developing this condition. Rarely it may be caused by n ...
The role of immunosuppression in the pathogenesis of basal cell
The role of immunosuppression in the pathogenesis of basal cell

... aetiology and pathogenesis of basal cell carcinoma (BCC) questioned the impact of a depressed immune system in the development of BCC.1 They alluded to the lack of evidence to support an increase in BCC incidence rates following organ transplantation and stated that ‘immunosuppression as practised a ...
Fungating wounds
Fungating wounds

... Fungating malignant wounds are caused by tumour infiltration of the skin and its supporting blood and lymph vessels.The tumours may be locally advanced, metastatic or recurrent. The tumours are treated by single or combination anti-cancer treatments to prevent the fungation extending. Anaerobic bact ...
Skin Disorders
Skin Disorders

... contaminants, resulting in serious risk of fatal infection. ...
Media Release
Media Release

... efficacy and safety data with ponesimod in patients with multiple sclerosis, including some who have been treated for more than 5 years. In addition, we have identified a gradual uptitration dosing regimen that could mitigate the known first-dose effects of this class of drug. This regimen has been ...
Vasculitis
Vasculitis

... Once remission has been induced (3-6 months) the dose of oral prednisolone is rapidly reduced and cyclophosphamide is usually replaced with azathioprine. Co-trimoxazole is usually given at a prophylactic dose (960 mg thrice weekly) in conjunction with cyclophosphamide to prevent Pneumocystis pneumon ...
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Systemic scleroderma



Systemic sclerosis or systemic scleroderma is an autoimmune or connective tissue disease. It is characterized by thickening of the skin caused by accumulation of collagen, and by injuries to the smallest arteries. There are two overlapping forms. Limited cutaneous scleroderma is limited to the skin on the face, hands and feet. Diffuse cutaneous scleroderma covers more of the skin, and is at risk of progressing to the visceral organs, including the kidneys, heart, lungs and gastrointestinal tract.Survival is determined by the severity of visceral disease. Prognosis is difficult to predict until the disease differentiates into recognizable subsets. Patients with limited cutaneous scleroderma have a good prognosis, with 10-year survival of 75%, although <10% develop pulmonary arterial hypertension after 10 to 20 years. Patients with diffuse cutaneous scleroderma have a 10-year survival of 55%. Death is most often from pulmonary, heart and kidney involvement, although survival has greatly improved with effective treatment for kidney failure. Immunosuppressive drugs are used, although glucocorticoids have limited application.Annual incidence is 19 per million, and prevalence is 19-75 per 100,000, with a female:male ratio of 3:1, and 8:1 in mid to late childbearing years. Incidence is twice as high among African Americans, and the Choctaw Native Americans in Oklahoma have the highest prevalence in the world (469/100,000). There is some hereditary association, some suggestion of immune reaction (molecular mimicry) to a virus, and some cases caused by toxins.
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