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autoimmune diseases
autoimmune diseases

...  characterized by muscle weakness and fatigue  the muscle weakness and neuromuscular dysfunction result from blockage and depletion of acetylcholine receptors at the myoneural ...
autoimmune diseases
autoimmune diseases

...  characterized by muscle weakness and fatigue  the muscle weakness and neuromuscular dysfunction result from blockage and depletion of acetylcholine receptors at the myoneural ...
A Short Review of Pigmentation Disorders in Systemic Diseases
A Short Review of Pigmentation Disorders in Systemic Diseases

Canine Renal Transplantation - PetCare Veterinary Hospital
Canine Renal Transplantation - PetCare Veterinary Hospital

... canine patient with renal failure has stemmed from two major problems. The genetic diversity of the dog along with a marked immune response to a kidney from an unrelated donor makes rejection a serious problem. We have attempted to overcome this rejection response with potent immunosuppressive drugs ...
Renal Failure
Renal Failure

... Anemia, bleeding tendencies, infection Increased incidence of cancer Hypertension, CHF, arrhythmias Uremic lung, dyspnea, pleural effusion Stomatitis, uremic fetor Neuro changes Renal osteodystrophy, osteomalacia, osteitis fibrosa, soft tissue calcification ...
skin and its dysfunction
skin and its dysfunction

... including hair and nails • To learn dermatologic conditions and their systemic associations • To identify these same conditions and associations from photographs ...
Externconference03-05
Externconference03-05

...  Active hair loss for 4 months  Abnormal skin manifestation on scalp, ...
Lupus Erythematosus Tumidus
Lupus Erythematosus Tumidus

... systemic LE.3 A slight male predominance (22 males and 18 females) was reported in one study2 but other papers showed a female predominance. The mean age at onset was 36.4 years (range 9 months to 54 years). ...
Lecture 2 - Autoimmune diseases
Lecture 2 - Autoimmune diseases

... Treatment NSAIDs (Non-steroidal anti-inflammatory drugs) Antimalarials (Hydroxychloroquine) ...
ICLS February 2011 Newsletter
ICLS February 2011 Newsletter

... Melasma is the development of a dark discolouration on the skin. Individual genetics and hormone levels, in combination with unprotected sun exposure can lead to an increased chance of developing Melasma. Although this condition can affect anyone, women are most often affected by Melasma. Pregnant w ...
Lipodermatosclerosis - Buffalo Medical Group
Lipodermatosclerosis - Buffalo Medical Group

... day and then taken off while lying in bed before going to sleep. Compression stockings can improve some of the changes in the skin and reduce the risk for further infections or ulcers. These usually can be obtained in surgical supply stores such as Bensons. There are different sizes and strengths an ...
Wegener`s Granulomatosis
Wegener`s Granulomatosis

... Epidemiology of WG y Incidence in US: appx. 10 per million y Prevalence in US: appx. 3 per 100.000 persons. y Much higher prevalence as 80% of 5year survival ...
Lupus Erythematosis - University of California, Irvine
Lupus Erythematosis - University of California, Irvine

... › Benlysta®: Inhibit B-lymphocyte Stimulator › Rituxan®: Tag and destroy B-cells › These and others reduce B-cell activity and thus auto- ...
GAMUNEX-C Infusion Rate Chart
GAMUNEX-C Infusion Rate Chart

... Renal dysfunction, acute renal failure, osmotic nephrosis, and death may occur with immune globulin intravenous (IVIG) products in predisposed patients. Patients predisposed to renal dysfunction include those with any degree of preexisting renal insufficiency, diabetes mellitus, age greater than 65, ...
GAMUNEX-C Infusion Rate Chart
GAMUNEX-C Infusion Rate Chart

... Renal dysfunction, acute renal failure, osmotic nephrosis, and death may occur with immune globulin intravenous (IVIG) products in predisposed patients. Patients predisposed to renal dysfunction include those with any degree of preexisting renal insufficiency, diabetes mellitus, age greater than 65, ...
Product Information - Aspen Pharmacare Australia
Product Information - Aspen Pharmacare Australia

... especially in patients with renal insufficiency. Quinolones: Citrates may reduce the solubility of ciprofloxacin, norfloxacin or ofloxacin in the urine. Patients should be observed for signs of crystalluria and nephrotoxicity. Laxatives: Concurrent administration of citrates with laxatives may have ...
PPT - Med Study Group
PPT - Med Study Group

... crescentic glomerulonephritis of the pauciimmune type are manifestations of smallvessel vasculitis or polyangiitis, which is limited to glomerular and perhaps peritubular capillaries in cases of idiopathic crescentic glomerulonephritis. ...
RENAL DISEASE
RENAL DISEASE

... Tumor/Cancer of renal and neighboring structures ...
Tolerance - BHS116.3 Physiology III
Tolerance - BHS116.3 Physiology III

... lack C1, C4, or C2 will get SLE.  Resulting in a lack of C3b and poor removal of immune complexes. Robbins’ Basic Pathology 5-21 ...
Chronic Renal Failure
Chronic Renal Failure

... Decreased appetite, metallic taste, nausea, vomiting 6. Hematologic: Normocytic anemia(decreased erythropoietin), bleeding (uremic platelet dysfunction) 7. Endocrine: Decrease 1,25-OH-VitD, hyperphosphatemia → hypocalcemia→ secondary hyperparathyroidism→ osteitis fibrosa cystica, osteomalacia, frac ...
Dermatology conditions should be treated in primary care where
Dermatology conditions should be treated in primary care where

...  Alopecia areata (always refer if there is diagnostic doubt or if scarring is present)  Androgenic alopecia  Hirsutism  Leg ulcers – patients can only been seen in the community service to exclude basal cell carcinoma or Bowen’s Disease. ...
KIDNEY DAMAGE IN AUTOIMMUNE DISEASES
KIDNEY DAMAGE IN AUTOIMMUNE DISEASES

... systemic lupus erythematosus (SLE). Nephritis is a major cause of morbidity and mortality and accounts for a large proportion of all hospital admissions in the lupus population. Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease with widespread clinical manifestations. ...
Skin disease: a cardinal feature of systemic
Skin disease: a cardinal feature of systemic

... stress)—and arthralgias of the fingers are common, early signs of SSc, and therefore helpful for establishing a diagnosis. Although there has been much debate about how best to classify SSc given its heterogeneity, the separation of SSc patients into one of two principal clinical subsets, dcSSc and ...
Genetics of scleroderma: implications for personalized medicine? Open Access
Genetics of scleroderma: implications for personalized medicine? Open Access

... B and T-cells are a normal component of the immune system. However, they are usually kept in check by regulatory mechanisms in the thymus/bone marrow or peripheral blood. In the concept of quantitative threshold, the implicated genetic variations lead cumulatively to an impairment of necessary biolo ...
The Itchy Patient - North Derbyshire CCG
The Itchy Patient - North Derbyshire CCG

... – No identifiable cause found in up to 50% pts – Can cause persistent and widespread itching and often extensive excoriation – Common in 7th decade and beyond ...
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Systemic scleroderma



Systemic sclerosis or systemic scleroderma is an autoimmune or connective tissue disease. It is characterized by thickening of the skin caused by accumulation of collagen, and by injuries to the smallest arteries. There are two overlapping forms. Limited cutaneous scleroderma is limited to the skin on the face, hands and feet. Diffuse cutaneous scleroderma covers more of the skin, and is at risk of progressing to the visceral organs, including the kidneys, heart, lungs and gastrointestinal tract.Survival is determined by the severity of visceral disease. Prognosis is difficult to predict until the disease differentiates into recognizable subsets. Patients with limited cutaneous scleroderma have a good prognosis, with 10-year survival of 75%, although <10% develop pulmonary arterial hypertension after 10 to 20 years. Patients with diffuse cutaneous scleroderma have a 10-year survival of 55%. Death is most often from pulmonary, heart and kidney involvement, although survival has greatly improved with effective treatment for kidney failure. Immunosuppressive drugs are used, although glucocorticoids have limited application.Annual incidence is 19 per million, and prevalence is 19-75 per 100,000, with a female:male ratio of 3:1, and 8:1 in mid to late childbearing years. Incidence is twice as high among African Americans, and the Choctaw Native Americans in Oklahoma have the highest prevalence in the world (469/100,000). There is some hereditary association, some suggestion of immune reaction (molecular mimicry) to a virus, and some cases caused by toxins.
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