Download Lupus Erythematosis - University of California, Irvine

yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project

Document related concepts

Antibody wikipedia , lookup

Syphilis wikipedia , lookup

Infection control wikipedia , lookup

Infection wikipedia , lookup

Cancer immunotherapy wikipedia , lookup

Blood type wikipedia , lookup

Periodontal disease wikipedia , lookup

Kawasaki disease wikipedia , lookup

Globalization and disease wikipedia , lookup

Polyclonal B cell response wikipedia , lookup

Hospital-acquired infection wikipedia , lookup

Rheumatic fever wikipedia , lookup

Multiple sclerosis research wikipedia , lookup

Guillain–Barré syndrome wikipedia , lookup

Azathioprine wikipedia , lookup

Hygiene hypothesis wikipedia , lookup

Psychoneuroimmunology wikipedia , lookup

Inflammation wikipedia , lookup

African trypanosomiasis wikipedia , lookup

Plasmodium falciparum wikipedia , lookup

Neonatal infection wikipedia , lookup

Systemic scleroderma wikipedia , lookup

Arthritis wikipedia , lookup

Neuromyelitis optica wikipedia , lookup

Schistosomiasis wikipedia , lookup

Ankylosing spondylitis wikipedia , lookup

Monoclonal antibody wikipedia , lookup

Autoimmunity wikipedia , lookup

Chickenpox wikipedia , lookup

Anti-nuclear antibody wikipedia , lookup

Sjögren syndrome wikipedia , lookup

Immunosuppressive drug wikipedia , lookup

Rheumatoid arthritis wikipedia , lookup

Systemic lupus erythematosus wikipedia , lookup

Autoimmune disease
› “The great imitator”
› Inflammation
› Episodic flares
 Mother-fetus Ab transfer
“The wolf” ca. 14th century
Serositis: inflammation of pleura, pericardium and peritoneum
Oral ulcers
Blood: Blood disorders like anemia, leukopenia, lymphopenia
and thrombocytopenia, cardiovascular disease
Renal disorder: Leading cause of death in SLE
Antinuclear antibodies: Anti-DNA, etc.
Immunologic disorder: Syphilis false positive, antiphospholipid
syndrome, susceptibility to infection
Neurologic Disorder: Can attack nervous system
Malar Rash: Butterfly rash on cheeks
Discoid Rash: Red, disc-shaped rashes.
Discoid Rash
Malar or “Butterfly” Rash
From RadioGraphics Journal
Malar rash
Estimated 5 million afflicted globally
› 1.5 million in the U.S.
› 16,000 new cases each year in the U.S.
Risk factors
› Genetics
 ITGAM, BANK1, TLR-7, STAT4, etc.
 FcγR Iib: Suspected Plasmodium resistance
› Ethnicity
 More prevalent in non-caucasians
› Sex
 More than 90% are female
No Cure
› Except drug-induced LE
Reduce inflammation
› Corticosteroids
Antimalarial drugs
› Hydroxychloroquine
› Methotrexate
› Azathioprine
› Opportunistic Infections?
Monoclonal Antibodies
› Benlysta®: Inhibit B-lymphocyte Stimulator
› Rituxan®: Tag and destroy B-cells
› These and others reduce B-cell activity and thus auto-
Mesenchymal Stem Cell Transplant
› Trials to for most severe cases
› Reset the immune system
The Lupus Foundation of America
Mayo Clinic: Lupus
Clatworthy et al. Systemic lupus erythematosus-associated
defects in the inhibitory receptor FcγRIIb reduce
susceptibility to malaria. PNAS. (2007) 104:7169-7174.
Yuan YJ, Luo XB, Shen N. Current advances in lupus genetic
and genomic studies in Asia. (2010) 19:1374-1383.
Liang et al. Allogenic mesenchymal stem cells
transplantation in refractory systemic lupus
erythematosus: a pilot clinical study. Ann Rheum Dis
(2010) 69:1423-1429