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Immunology
Immunology

... immune cells attack and inflame the membrane around joints. It also can affect the heart, lungs, and eyes.  Scleroderma – activation of immune cells that produces scar tissue in the skin, internal organs, and small blood vessels.  Sjögren's syndrome – aka Sjögren's disease, is a chronic, slowly pr ...
skin in systemic
skin in systemic

... Renal disorders Gastro-intestinal and Liver disorders ...
RESIDENT REPORT - oliveviewim.org
RESIDENT REPORT - oliveviewim.org

...  Systemic corticosteroids are of unproven benefit  May require liver transplantation Lung or kidney:  Systemic corticosteroids (minimum of 0.1mg/kg prednisone) until clinical improvement and normalization of labs; tapered over 8-12 weeks  Has not been evaluated in RCTs No studies evaluating the ...
1. Systemic autoimmune disease
1. Systemic autoimmune disease

... Rheumatoid Arthritis (RA) is characterised by persistent inflammation of the synovium leading to varying degrees of joint destruction. The disease is associated with HLA-DR4 and HLA-DR1 and occurs more frequently in women. The target autoantigen is unknown, although type II collagen is a candidate. ...
Preview of the Medifocus Guidebook on: Scleroderma Updated
Preview of the Medifocus Guidebook on: Scleroderma Updated

... internal organs. The term scleroderma literally means hardening (also called fibrosis) of the skin. The cause of scleroderma is unknown, but the disease process is related to a malfunction of the vascular and immune systems. Researchers believe that the immune system, which protects us against infec ...
Connective Tissue Diseases
Connective Tissue Diseases

... Discoid lupus erythematosus (localized) Discoid lupus erythematosus (generalized) Verrucous lupus erythematosus Subacute cutaneous lupus erythematosus Systemic lupus erythematosus Lupus erythematosus profundus Lupus erythematosus–erythema multiforme syndrome Drug-induced lupus erythematosus Chilblai ...
Document
Document

... group of disorders with low Igs. • They have normal B cell, but they do not differentiated to plasma cells. ...
DEFINITION: Progressive and irreversible deterioration of
DEFINITION: Progressive and irreversible deterioration of

... HTN, glomerulonephritis, cystic kidney disease, urologic diseases, and idiopathic means. Direct viral or bacterial infection (septic, UTI) can also cause nephritis. ...
IMMUNOLOGIC DEFICIENCY SYNDROMES
IMMUNOLOGIC DEFICIENCY SYNDROMES

... Anticentromere antibodies (20-30%)—indicates increased risk for pulmonary hypertension & CREST CREST syndrome common: Calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangietasia ...
Medical-Surgical Nursing: An Integrated Approach, 2E Chapter 22
Medical-Surgical Nursing: An Integrated Approach, 2E Chapter 22

... Any client receiving blood products that are homologous or from a donor may develop a transfusion reaction.  Five types: febrile nonhemolytic; allergic urticarial; delayed hemolytic; acute hemolytic; and anaphylactic. ...
laboratory tests in rheumatology
laboratory tests in rheumatology

...  Each rheumatic disease has a set of criteria used to make the diagnosis of that particular disease process. A lab test is just a small portion of that.  Normal individuals may have positive autoantibody tests without any disease process.  None of these tests is perfect. ...
Autoimmunity and Autoimmune Diseases
Autoimmunity and Autoimmune Diseases

... Anti-topoisomerase I (anti-Scl70) ...
PDF - Journal of Nephropathology
PDF - Journal of Nephropathology

... a patient with any gadolinium agent exposure has been reported to range 1.13-3.4%, making it a rare entity (4). To diagnose NSF, a scoring system of clinical and histopathological criteria has been used. Several pathophysiological mechanisms have been proposed, and it appears to be related to increa ...


... a patient with any gadolinium agent exposure has been reported to range 1.13-3.4%, making it a rare entity (4). To diagnose NSF, a scoring system of clinical and histopathological criteria has been used. Several pathophysiological mechanisms have been proposed, and it appears to be related to increa ...
Ocular Autoimmune Disease: An Introduction
Ocular Autoimmune Disease: An Introduction

... the body to eventually re-regulate itself, with the result often being that after the patient has been kept on systemic medications to suppress the inappropriate immune response for a finite length of time (for example, one year), medication can then be tapered and stopped without recurrence of the ...
Notalgia Paresthetica - Buffalo Medical Group
Notalgia Paresthetica - Buffalo Medical Group

... patients to any other skin problems. A small number of patients with N.P. may develop a darker patch of skin on their back, but this is not dangerous and is not present in most forms of the condition. Because the dark patch of skin is thought to develop after frequent scratching, early treatment of ...
Tolerance, Immune Regulation, and Autoimmunity
Tolerance, Immune Regulation, and Autoimmunity

... • RF may be a marker but may not be a mechanism. ...
Pathophys - Renal - Systemic_vascular_hereditary
Pathophys - Renal - Systemic_vascular_hereditary

... ~Early clinical manifestation: proteinuria ~Only biopsy if: early onset renal disease, lack of retinal changes, unexplained hematuria or unusually accelerated renal impairment ~Excess ECM components ~May be related to TGF-β ...
Allergy and Immune Disorders
Allergy and Immune Disorders

... Not directly inherited, possibly a family hx of rheumatic diseases S/S: chronic hardening and thickening of the skin caused by new collagen formation, skin changes include edema and pallor, then firmness of the skin; systemic scleroderma is due to injury to blood vessels and to fibrosis or scarring ...
PAS 1820 - Miami Dade College
PAS 1820 - Miami Dade College

... Allergic, Drug and Sun Reactions of the Skin ...
Sub acute Bacterial Endocarditis Endocarditis
Sub acute Bacterial Endocarditis Endocarditis

... commonly of PR3-ANCA (cANCA) specificity In renal limited forms. ...
Rheumatology
Rheumatology

... – Patients still mildly symptomatic following NSAID use may be started on sulfasalazine or hydroxychloroquine and analgesics, as needed – Moderate disease can be treated with methotrexate; anti-tumor necrosis factor (TNF) drugs (e.g., infliximab) or corticosteroids may be considered – Anti-TNF drugs ...
transplantation
transplantation

... in kidney and alveoli in lungs ...
Self tolerance
Self tolerance

... neurologic deficits and/or neuropsychiatric symptoms ...
Latent TB In Patients With Chronic Renal Failure
Latent TB In Patients With Chronic Renal Failure

... Latent TB in Patients with Chronic renal failure- results from a national survey. Background: Patients with chronic renal failure are especially prone to infections due to dampened adaptive immunity. Tuberculosis in particular poses a significant risk including the potential for antiTB drugs to furt ...
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Systemic scleroderma



Systemic sclerosis or systemic scleroderma is an autoimmune or connective tissue disease. It is characterized by thickening of the skin caused by accumulation of collagen, and by injuries to the smallest arteries. There are two overlapping forms. Limited cutaneous scleroderma is limited to the skin on the face, hands and feet. Diffuse cutaneous scleroderma covers more of the skin, and is at risk of progressing to the visceral organs, including the kidneys, heart, lungs and gastrointestinal tract.Survival is determined by the severity of visceral disease. Prognosis is difficult to predict until the disease differentiates into recognizable subsets. Patients with limited cutaneous scleroderma have a good prognosis, with 10-year survival of 75%, although <10% develop pulmonary arterial hypertension after 10 to 20 years. Patients with diffuse cutaneous scleroderma have a 10-year survival of 55%. Death is most often from pulmonary, heart and kidney involvement, although survival has greatly improved with effective treatment for kidney failure. Immunosuppressive drugs are used, although glucocorticoids have limited application.Annual incidence is 19 per million, and prevalence is 19-75 per 100,000, with a female:male ratio of 3:1, and 8:1 in mid to late childbearing years. Incidence is twice as high among African Americans, and the Choctaw Native Americans in Oklahoma have the highest prevalence in the world (469/100,000). There is some hereditary association, some suggestion of immune reaction (molecular mimicry) to a virus, and some cases caused by toxins.
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