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Therapeutics Update
Product News
FDAACTIONS
New Wrinkle Therapy Approved. A first-of-its kind wrinkle therapy
is available to patients, following FDA’s approval last month of the
BLA for LaViv (azficel-T, Fibrocell Science) personalized aesthetic
cell therapy.
LaViv was approved for treatment of nasolabial folds, based on two
identical Phase III multi-center, randomized, double-blind, placebo-controlled studies involving 421 patients. Treatment was
administered in three sessions approximately five weeks apart.
Based on investigators’ and patients’ assessments, a significantly
greater proportion of patients demonstrated a positive response
to treatment with LaViv than with placebo. Treatment was shown to
improve the appearance of nasolabial fold wrinkles for six months
after the third and final treatment.
The approval of LaViv offers an attractive new option for wrinkle
treatment, suggests study investigator Robert A. Weiss, MD,
Clinical Associate Professor, Johns Hopkins School of Medicine and
Director, Maryland Laser Skin and Vein Institute. He stresses that
LaViv is not a volume filler like Juvéderm or Restylane, rather it is
intended for finer wrinkles closer to the surface of the skin. The
injection contains no collagen but consists of fibroblasts to
encourage endogenous collagen production.
According to Dr. Weiss, the process is relatively straightforward.
The area behind the ear is anesthetized with lidocaine before 23mm punch biopsies are taken. The biopsy materials are placed in
a transport medium and then shipped out for processing. The
roughly six-week processing technique purifies and multiplies
fibroblasts, which are then harvested and shipped back to the clinic for arrival one day before the patient’s scheduled treatment.
Materials need only be refrigerated, not frozen. When the patient
presents, fibroblasts are injected superficially in the dermis. Dr.
Weiss explains to patients that the “collagen producing cells rev
up in that laboratory environment. They are revved up and ready
to produce collagen when re-injected.”
Dr. Weiss predicts strong acceptance of the process, as patients
“really do embrace the concept of using their own cells.” He says
that the procedure won’t be intimidating for patients or physicians
and that physicians will receive training on harvesting samples
and injecting firboblasts. He also indicates that use of a standard
anti-aging regimen, including topical retinoids that also stimulate
fibroblasts, should be used in conjunction with the technique.
56 | Practical Dermatology
| July 2011
Fight Acne and Age
There’s a new option for treating acne and signs of
skin aging. Age Intervention Duality MD from Jan
Marini Skin Research is designed for all skin types. It
features micronized benzoyl peroxide 10% along with
the peptide Myristoyl Tripeptide-4, and all-TransRetinol to target acne. For anti-aging benefits, the formulation contains peptides palmitoyl Oligopeptide
and Palmitoyl Tetrapeptide-7, green tea extract,
chrysin, bisabolol, NHS, and hyaluronic acid. The formulations are available in a 1oz. dual chamber pump
for office dispensing. Janmarini.com
Connecting Collagen
Advanced Connective Tissue Formula is
described by Collagen MD as a premium
collagen nutricosmetic supplement that
provides specialized nutritional support
for health skin and connective tissue
throughout the body. A proprietary blend
of pharmaceutical-grade Collagen Type I
& III peptides, hyaluronic acid, and vitamins, Advanced Connective Tissue Formula comes in
an easy-to-take powdered form and has a neutral
taste. Collagenmdprofessional.com
Lock Moisture, Block Sun
A new broad-spectrum UVA and UVB
protection sunscreen from Envy Medical,
Lumixyl Moisturelock Sunscreen SPF 30
is a physical sunscreen with micronized
titanium dioxide. Lumixyl MoistureLock
Sunscreen uses a proprietary method to
allow for an even application that goes on
smoothly and invisibly rubs on the skin.
It also contains Symhelios 1031, which
blocks toxic interactions that otherwise
take place between UVB rays and the
proteins in the skin cells that may otherwise damage
skin structure. Envymedical.com
Fight Acne Without Irritation
Avene’s new TriAcneal combats acne breakouts and
Therapeutics Update
Product News
minimizes the appearance of lines and
wrinkles with little or no irritation, the
company says. TriAcneal is formulated
with Efectiose, a bio-available ingredient
to treat inflammation, scarring, and
excessive cell build-up associated with
acne. It also contains retinaldehyde,
which helps to stimulate elastin and collagen synthesis, and glycolic acid, which
exfoliates and cleanses the skin. In a sixweek trial, 27 percent of participants
reported a rapid decrease of retentional
acne lesions after 15 days of use, and 42 percent of
participants reported a long-lasting reduction of
inflammatory acne lesions after six weeks of use,
according to Avene. TriAcneal will be available in
September 2011. Aveneusa.com
New Barrier Ointment Available
Replenix ResurFIX Skin Barrier Healing Ointment, an
all-in-one recovery formula that cools, soothes and
restores skin post-procedure is now available from
Topix Pharmaceuticals. Containing Ceramides 2 and
3, green tea extract, vitamin E, allantoin, and other
ingredients, ResurFIX cosmetically improves the
appearance of scar tissue and creates an effective skin
barrier that allows for the texture renewal of stressed
skin, the company says. TopixPharm.com
iPixel Expands
Two new modules-the iPixel CO2, and the iPixelEr-are
available from Alma Lasers. Each features Alma's
roller-style technology for fast, safe treatments with
maneuverability and versatility. The new iPixel series
modules can be used with existing Alma systems. The
iPixelEr, for use with the HarmonyXL, offers rapid
treatment and is available with three applicator tips.
The iPixelCO2, for use with the Pixel CO2 system,
channels 70 Watts of energy into only seven pixels;
pulses are released as the roller wheels turn, regardless of the speed at which the handpiece is moving. It
is intended for removal of fine lines, wrinkles, postacne scars and skin rejuvenation. Almalasers.com
Back For Less
For patients with back acne, consider
Glytone’s new Back Acne Spray, a quickdrying, fragrance free product containing
2% salicyclic acid. Available in a pump
bottle designed for convenient upside
down spraying and even dispersion of the
formula, Glytone Back Acne Spray treats
mild acne as well as improves skin texture and scars. Glytone-usa.com ■
Advertising Index July 2011
Advertiser. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Page
Abbott Laboratories. • www.humira.com
Humira . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .39-44
Cosmetic Surgery Forum • www.cosmeticsurgeryforum.com
Discussions In Dermatology . . . . . . . . . . . . . . . . . . . . . . .57
Coria Laboratories • www.corialabs.com
Acanya . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15-16
Atralin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27-28
Refissa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9-10
Galderma • www.galdermausa.com
Clobex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-3
Intendis • www.intendis.com
Desonate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .31-32
Iridex • www.iridex.com
Gemini & VariLite . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .47
Merz • www.merz.com
Mederma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13
Ortho Dermatologics • www.orthodermatologics.com
Retin-A Micro . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .58
Promius Pharma • www.promiuspharma.com
Cloderm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1a, 19-22
Stiefel, a GSK Company • www.stiefel.com
Duac . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .61-62
For advertising inquiries please contact:
Alan Guralnick, Group Publisher
[email protected] • 484-581-1832
Ali Kinnie, Publisher
[email protected] • 917-589-4160
July 2011 |
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