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Therapeutics Update Product News FDAACTIONS New Wrinkle Therapy Approved. A first-of-its kind wrinkle therapy is available to patients, following FDA’s approval last month of the BLA for LaViv (azficel-T, Fibrocell Science) personalized aesthetic cell therapy. LaViv was approved for treatment of nasolabial folds, based on two identical Phase III multi-center, randomized, double-blind, placebo-controlled studies involving 421 patients. Treatment was administered in three sessions approximately five weeks apart. Based on investigators’ and patients’ assessments, a significantly greater proportion of patients demonstrated a positive response to treatment with LaViv than with placebo. Treatment was shown to improve the appearance of nasolabial fold wrinkles for six months after the third and final treatment. The approval of LaViv offers an attractive new option for wrinkle treatment, suggests study investigator Robert A. Weiss, MD, Clinical Associate Professor, Johns Hopkins School of Medicine and Director, Maryland Laser Skin and Vein Institute. He stresses that LaViv is not a volume filler like Juvéderm or Restylane, rather it is intended for finer wrinkles closer to the surface of the skin. The injection contains no collagen but consists of fibroblasts to encourage endogenous collagen production. According to Dr. Weiss, the process is relatively straightforward. The area behind the ear is anesthetized with lidocaine before 23mm punch biopsies are taken. The biopsy materials are placed in a transport medium and then shipped out for processing. The roughly six-week processing technique purifies and multiplies fibroblasts, which are then harvested and shipped back to the clinic for arrival one day before the patient’s scheduled treatment. Materials need only be refrigerated, not frozen. When the patient presents, fibroblasts are injected superficially in the dermis. Dr. Weiss explains to patients that the “collagen producing cells rev up in that laboratory environment. They are revved up and ready to produce collagen when re-injected.” Dr. Weiss predicts strong acceptance of the process, as patients “really do embrace the concept of using their own cells.” He says that the procedure won’t be intimidating for patients or physicians and that physicians will receive training on harvesting samples and injecting firboblasts. He also indicates that use of a standard anti-aging regimen, including topical retinoids that also stimulate fibroblasts, should be used in conjunction with the technique. 56 | Practical Dermatology | July 2011 Fight Acne and Age There’s a new option for treating acne and signs of skin aging. Age Intervention Duality MD from Jan Marini Skin Research is designed for all skin types. It features micronized benzoyl peroxide 10% along with the peptide Myristoyl Tripeptide-4, and all-TransRetinol to target acne. For anti-aging benefits, the formulation contains peptides palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7, green tea extract, chrysin, bisabolol, NHS, and hyaluronic acid. The formulations are available in a 1oz. dual chamber pump for office dispensing. Janmarini.com Connecting Collagen Advanced Connective Tissue Formula is described by Collagen MD as a premium collagen nutricosmetic supplement that provides specialized nutritional support for health skin and connective tissue throughout the body. A proprietary blend of pharmaceutical-grade Collagen Type I & III peptides, hyaluronic acid, and vitamins, Advanced Connective Tissue Formula comes in an easy-to-take powdered form and has a neutral taste. Collagenmdprofessional.com Lock Moisture, Block Sun A new broad-spectrum UVA and UVB protection sunscreen from Envy Medical, Lumixyl Moisturelock Sunscreen SPF 30 is a physical sunscreen with micronized titanium dioxide. Lumixyl MoistureLock Sunscreen uses a proprietary method to allow for an even application that goes on smoothly and invisibly rubs on the skin. It also contains Symhelios 1031, which blocks toxic interactions that otherwise take place between UVB rays and the proteins in the skin cells that may otherwise damage skin structure. Envymedical.com Fight Acne Without Irritation Avene’s new TriAcneal combats acne breakouts and Therapeutics Update Product News minimizes the appearance of lines and wrinkles with little or no irritation, the company says. TriAcneal is formulated with Efectiose, a bio-available ingredient to treat inflammation, scarring, and excessive cell build-up associated with acne. It also contains retinaldehyde, which helps to stimulate elastin and collagen synthesis, and glycolic acid, which exfoliates and cleanses the skin. In a sixweek trial, 27 percent of participants reported a rapid decrease of retentional acne lesions after 15 days of use, and 42 percent of participants reported a long-lasting reduction of inflammatory acne lesions after six weeks of use, according to Avene. TriAcneal will be available in September 2011. Aveneusa.com New Barrier Ointment Available Replenix ResurFIX Skin Barrier Healing Ointment, an all-in-one recovery formula that cools, soothes and restores skin post-procedure is now available from Topix Pharmaceuticals. Containing Ceramides 2 and 3, green tea extract, vitamin E, allantoin, and other ingredients, ResurFIX cosmetically improves the appearance of scar tissue and creates an effective skin barrier that allows for the texture renewal of stressed skin, the company says. TopixPharm.com iPixel Expands Two new modules-the iPixel CO2, and the iPixelEr-are available from Alma Lasers. Each features Alma's roller-style technology for fast, safe treatments with maneuverability and versatility. The new iPixel series modules can be used with existing Alma systems. The iPixelEr, for use with the HarmonyXL, offers rapid treatment and is available with three applicator tips. The iPixelCO2, for use with the Pixel CO2 system, channels 70 Watts of energy into only seven pixels; pulses are released as the roller wheels turn, regardless of the speed at which the handpiece is moving. It is intended for removal of fine lines, wrinkles, postacne scars and skin rejuvenation. Almalasers.com Back For Less For patients with back acne, consider Glytone’s new Back Acne Spray, a quickdrying, fragrance free product containing 2% salicyclic acid. Available in a pump bottle designed for convenient upside down spraying and even dispersion of the formula, Glytone Back Acne Spray treats mild acne as well as improves skin texture and scars. Glytone-usa.com ■ Advertising Index July 2011 Advertiser. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Page Abbott Laboratories. • www.humira.com Humira . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .39-44 Cosmetic Surgery Forum • www.cosmeticsurgeryforum.com Discussions In Dermatology . . . . . . . . . . . . . . . . . . . . . . .57 Coria Laboratories • www.corialabs.com Acanya . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15-16 Atralin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27-28 Refissa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9-10 Galderma • www.galdermausa.com Clobex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-3 Intendis • www.intendis.com Desonate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .31-32 Iridex • www.iridex.com Gemini & VariLite . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .47 Merz • www.merz.com Mederma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13 Ortho Dermatologics • www.orthodermatologics.com Retin-A Micro . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .58 Promius Pharma • www.promiuspharma.com Cloderm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1a, 19-22 Stiefel, a GSK Company • www.stiefel.com Duac . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .61-62 For advertising inquiries please contact: Alan Guralnick, Group Publisher [email protected] • 484-581-1832 Ali Kinnie, Publisher [email protected] • 917-589-4160 July 2011 | Practical Dermatology | 59